Dietary Habits and Intestinal Immunity: From Food Intake to CD4(+) T-H Cells
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Dietary Habits and Intestinal Immunity: From Food Intake to CD4(+) T-H Cells. / Siracusa, Francesco; Schaltenberg, Nicola; Villablanca, Eduardo J; Huber, Samuel; Gagliani, Nicola.
in: FRONT IMMUNOL, Jahrgang 9, 15.01.2019, S. 3177.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Dietary Habits and Intestinal Immunity: From Food Intake to CD4(+) T-H Cells
AU - Siracusa, Francesco
AU - Schaltenberg, Nicola
AU - Villablanca, Eduardo J
AU - Huber, Samuel
AU - Gagliani, Nicola
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Dietary habits have a profound impact on intestinal homeostasis and in general on human health. In Western countries, high intake of calories derived from fried products, butter and processed meat is favored over dietary regimens rich in fruits and vegetables. This type of diet is usually referred to as Western-type diet (WTD) and it has been associated with several metabolic and chronic inflammatory conditions of the gastrointestinal tract. In this review, we describe how WTD promotes intestinal and extra-intestinal inflammation and alters mucosal immunity acting on CD4+ T cells in a microbiota-dependent or -independent fashion, ultimately leading to higher susceptibility to infectious and autoimmune diseases. Moreover, summarizing recent findings, we propose how dietary supplementation with fiber and vitamins could be used as a tool to modulate CD4+ T cell phenotype and function, ameliorating inflammation and restoring mucosal homeostasis.
AB - Dietary habits have a profound impact on intestinal homeostasis and in general on human health. In Western countries, high intake of calories derived from fried products, butter and processed meat is favored over dietary regimens rich in fruits and vegetables. This type of diet is usually referred to as Western-type diet (WTD) and it has been associated with several metabolic and chronic inflammatory conditions of the gastrointestinal tract. In this review, we describe how WTD promotes intestinal and extra-intestinal inflammation and alters mucosal immunity acting on CD4+ T cells in a microbiota-dependent or -independent fashion, ultimately leading to higher susceptibility to infectious and autoimmune diseases. Moreover, summarizing recent findings, we propose how dietary supplementation with fiber and vitamins could be used as a tool to modulate CD4+ T cell phenotype and function, ameliorating inflammation and restoring mucosal homeostasis.
KW - Journal Article
KW - Review
U2 - 10.3389/fimmu.2018.03177
DO - 10.3389/fimmu.2018.03177
M3 - SCORING: Review article
C2 - 30697217
VL - 9
SP - 3177
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -
