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Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.

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Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1. / Ullrich, Susanne; Zhang, Ying; Avram, Diana; Ranta, Felicia; Kuhl, Dietmar; Häring, Hans-Ulrich; Lang, Florian.

in: BIOCHEM BIOPH RES CO, Jahrgang 352, Nr. 3, 3, 2007, S. 662-667.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ullrich, S, Zhang, Y, Avram, D, Ranta, F, Kuhl, D, Häring, H-U & Lang, F 2007, 'Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.', BIOCHEM BIOPH RES CO, Jg. 352, Nr. 3, 3, S. 662-667. <http://www.ncbi.nlm.nih.gov/pubmed/17157265?dopt=Citation>

APA

Ullrich, S., Zhang, Y., Avram, D., Ranta, F., Kuhl, D., Häring, H-U., & Lang, F. (2007). Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1. BIOCHEM BIOPH RES CO, 352(3), 662-667. [3]. http://www.ncbi.nlm.nih.gov/pubmed/17157265?dopt=Citation

Vancouver

Ullrich S, Zhang Y, Avram D, Ranta F, Kuhl D, Häring H-U et al. Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1. BIOCHEM BIOPH RES CO. 2007;352(3):662-667. 3.

Bibtex

@article{114f3639a03540f3b3f6adcb50363c22,
title = "Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.",
abstract = "Glucocorticoids blunt insulin release, an effect partially due to activation of Kv channels. Similar to those channels Na+/K+ ATPase activity repolarizes the plasma membrane. The present study explored whether glucocorticoids increase the Na+/K+ ATPase activity in pancreatic beta-cells. The glucocorticoid dexamethasone (100 nmol/l for 1 day) significantly increased Na+/K+ ATPase alpha1/beta1-subunit transcript levels and ouabain-sensitive outward current reflecting Na+/K+ ATPase activity in INS-1 cells, effects blunted by glucocorticoid-receptor-blocker RU487 (1 micromol/l). Dexamethasone (100 nmol/l) increased K+ current in beta-cells from wild type mice but not from knockout mice lacking functional serum and glucocorticoid inducible kinase SGK1. Thus, glucocorticoids indeed up-regulate Na+/K+ ATPase activity, an effect requiring SGK1.",
author = "Susanne Ullrich and Ying Zhang and Diana Avram and Felicia Ranta and Dietmar Kuhl and Hans-Ulrich H{\"a}ring and Florian Lang",
year = "2007",
language = "Deutsch",
volume = "352",
pages = "662--667",
journal = "BIOCHEM BIOPH RES CO",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.

AU - Ullrich, Susanne

AU - Zhang, Ying

AU - Avram, Diana

AU - Ranta, Felicia

AU - Kuhl, Dietmar

AU - Häring, Hans-Ulrich

AU - Lang, Florian

PY - 2007

Y1 - 2007

N2 - Glucocorticoids blunt insulin release, an effect partially due to activation of Kv channels. Similar to those channels Na+/K+ ATPase activity repolarizes the plasma membrane. The present study explored whether glucocorticoids increase the Na+/K+ ATPase activity in pancreatic beta-cells. The glucocorticoid dexamethasone (100 nmol/l for 1 day) significantly increased Na+/K+ ATPase alpha1/beta1-subunit transcript levels and ouabain-sensitive outward current reflecting Na+/K+ ATPase activity in INS-1 cells, effects blunted by glucocorticoid-receptor-blocker RU487 (1 micromol/l). Dexamethasone (100 nmol/l) increased K+ current in beta-cells from wild type mice but not from knockout mice lacking functional serum and glucocorticoid inducible kinase SGK1. Thus, glucocorticoids indeed up-regulate Na+/K+ ATPase activity, an effect requiring SGK1.

AB - Glucocorticoids blunt insulin release, an effect partially due to activation of Kv channels. Similar to those channels Na+/K+ ATPase activity repolarizes the plasma membrane. The present study explored whether glucocorticoids increase the Na+/K+ ATPase activity in pancreatic beta-cells. The glucocorticoid dexamethasone (100 nmol/l for 1 day) significantly increased Na+/K+ ATPase alpha1/beta1-subunit transcript levels and ouabain-sensitive outward current reflecting Na+/K+ ATPase activity in INS-1 cells, effects blunted by glucocorticoid-receptor-blocker RU487 (1 micromol/l). Dexamethasone (100 nmol/l) increased K+ current in beta-cells from wild type mice but not from knockout mice lacking functional serum and glucocorticoid inducible kinase SGK1. Thus, glucocorticoids indeed up-regulate Na+/K+ ATPase activity, an effect requiring SGK1.

M3 - SCORING: Zeitschriftenaufsatz

VL - 352

SP - 662

EP - 667

JO - BIOCHEM BIOPH RES CO

JF - BIOCHEM BIOPH RES CO

SN - 0006-291X

IS - 3

M1 - 3

ER -