Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.
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Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography. / Erttmann, Rudolf; Bielack, S; Landbeck, G.
in: ONCOLOGY-BASEL, Jahrgang 43, Nr. 2, 2, 1986, S. 86-88.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.
AU - Erttmann, Rudolf
AU - Bielack, S
AU - Landbeck, G
PY - 1986
Y1 - 1986
N2 - A rapid and sensitive reversed phase HPLC method was developed for the detection of 7-hydroxymethotrexate (7-OHMTX) which is the main metabolite in human plasma after high-dose methotrexate (MTX) therapy. The simple clean-up procedure of plasma samples described allows the measurement of 7-OHMTX during clinical management of MTX infusions. Elimination kinetics of 7-OHMTX are given from 53 drug cycles of 6 patients.
AB - A rapid and sensitive reversed phase HPLC method was developed for the detection of 7-hydroxymethotrexate (7-OHMTX) which is the main metabolite in human plasma after high-dose methotrexate (MTX) therapy. The simple clean-up procedure of plasma samples described allows the measurement of 7-OHMTX during clinical management of MTX infusions. Elimination kinetics of 7-OHMTX are given from 53 drug cycles of 6 patients.
M3 - SCORING: Zeitschriftenaufsatz
VL - 43
SP - 86
EP - 88
JO - ONCOLOGY-BASEL
JF - ONCOLOGY-BASEL
SN - 0030-2414
IS - 2
M1 - 2
ER -