Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response.
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Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response. / Jäger, Markus; Riedel, Michael; Schmauss, Max; Pfeiffer, Herbert; Laux, Gerd; Naber, Dieter; Gaebel, Wolfgang; Huff, Wolfgang; Schmidt, Lutz G; Heuser, Isabella; Buchkremer, Gerhard; Kühn, Kai-Uwe; Rüther, Eckart; Hoff, Paul; Gastpar, Markus; Bottlender, Ronald; Strauss, Anton; Möller, Hans-Jürgen.
in: PSYCHIAT RES, Jahrgang 158, Nr. 3, 3, 2008, S. 297-305.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response.
AU - Jäger, Markus
AU - Riedel, Michael
AU - Schmauss, Max
AU - Pfeiffer, Herbert
AU - Laux, Gerd
AU - Naber, Dieter
AU - Gaebel, Wolfgang
AU - Huff, Wolfgang
AU - Schmidt, Lutz G
AU - Heuser, Isabella
AU - Buchkremer, Gerhard
AU - Kühn, Kai-Uwe
AU - Rüther, Eckart
AU - Hoff, Paul
AU - Gastpar, Markus
AU - Bottlender, Ronald
AU - Strauss, Anton
AU - Möller, Hans-Jürgen
PY - 2008
Y1 - 2008
N2 - The aim of the present study was to examine the relevance of depressive symptoms during an acute schizophrenic episode for the prediction of treatment response. Two hundred inpatients who fulfilled DSM-IV criteria for schizophrenia or schizophreniform disorders were assessed at hospital admission and after 6 weeks of inpatient treatment using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Rating Scale for Depression (HAM-D). Depressive symptoms showed positive correlations with both positive and negative symptoms at admission and after 6 weeks, and decreased during 6 weeks of treatment. Pronounced depressive symptoms (HAM-D score> or =16) were found in 28% of the sample at admission and in 9% after 6 weeks of treatment. Depressive symptoms at admission predicted a greater improvement of positive and negative symptoms over 6 weeks of treatment, but also more, rather than fewer remaining symptoms after 6 weeks. Both results, however, lost statistical significance when analyses were controlled for the influence of positive and negative symptoms at admission. Therefore, the hypothesis that depressive symptoms are predictive of a favorable treatment response was not supported by the present study.
AB - The aim of the present study was to examine the relevance of depressive symptoms during an acute schizophrenic episode for the prediction of treatment response. Two hundred inpatients who fulfilled DSM-IV criteria for schizophrenia or schizophreniform disorders were assessed at hospital admission and after 6 weeks of inpatient treatment using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Rating Scale for Depression (HAM-D). Depressive symptoms showed positive correlations with both positive and negative symptoms at admission and after 6 weeks, and decreased during 6 weeks of treatment. Pronounced depressive symptoms (HAM-D score> or =16) were found in 28% of the sample at admission and in 9% after 6 weeks of treatment. Depressive symptoms at admission predicted a greater improvement of positive and negative symptoms over 6 weeks of treatment, but also more, rather than fewer remaining symptoms after 6 weeks. Both results, however, lost statistical significance when analyses were controlled for the influence of positive and negative symptoms at admission. Therefore, the hypothesis that depressive symptoms are predictive of a favorable treatment response was not supported by the present study.
M3 - SCORING: Zeitschriftenaufsatz
VL - 158
SP - 297
EP - 305
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 3
M1 - 3
ER -
