Decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype.
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Decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype. / Hinkelmann, Kim; Dragoi, Laura; Gompf, Julia; Muhtz, Christoph; Demiralay, Cüneyt; Yassouridis, Alexander; Wiedemann, Klaus; Kellner, Michael.
in: PSYCHIAT RES, Jahrgang 177, Nr. 3, 3, 2010, S. 354-357.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype.
AU - Hinkelmann, Kim
AU - Dragoi, Laura
AU - Gompf, Julia
AU - Muhtz, Christoph
AU - Demiralay, Cüneyt
AU - Yassouridis, Alexander
AU - Wiedemann, Klaus
AU - Kellner, Michael
PY - 2010
Y1 - 2010
N2 - Selective serotonin reuptake inhibitors (SSRIs) are known to influence the information processing of emotional material in depressed patients and healthy controls. The functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to interact with the effectiveness of serotonin reuptake inhibitors. It is not known whether 5-HTTLPR has an influence on emotional processing in healthy controls. We report first data with long-term SSRI administration after genetic characterization of 5-HTTLPR in a randomized, double-blind, placebo-controlled, crossover design. In 30 healthy controls, 15 homozygous for the long and 15 for the short allele of 5-HTTLPR, emotionally valent images were used to elicit positive or negative emotions. We found a diminished perception of sad and fearful information under SSRI which was significant in the long allele group. These findings emphasize the importance of genetic variance in emotion processing research.
AB - Selective serotonin reuptake inhibitors (SSRIs) are known to influence the information processing of emotional material in depressed patients and healthy controls. The functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to interact with the effectiveness of serotonin reuptake inhibitors. It is not known whether 5-HTTLPR has an influence on emotional processing in healthy controls. We report first data with long-term SSRI administration after genetic characterization of 5-HTTLPR in a randomized, double-blind, placebo-controlled, crossover design. In 30 healthy controls, 15 homozygous for the long and 15 for the short allele of 5-HTTLPR, emotionally valent images were used to elicit positive or negative emotions. We found a diminished perception of sad and fearful information under SSRI which was significant in the long allele group. These findings emphasize the importance of genetic variance in emotion processing research.
M3 - SCORING: Zeitschriftenaufsatz
VL - 177
SP - 354
EP - 357
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 3
M1 - 3
ER -
