[Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous]
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[Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous]. / Brune, K; Renner, B; Maas, Renke.
in: DEUT MED WOCHENSCHR, Jahrgang 134, Nr. 36, 36, 2009, S. 1771-1773.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous]
AU - Brune, K
AU - Renner, B
AU - Maas, Renke
PY - 2009
Y1 - 2009
N2 - Non-steroidal, anti-inflammatory drugs are the most widely used remedies worldwide. Drug interactions are frequent, life threatening ones are rare: Bleeds on the basis of inhibition of platelet aggregation and loss of organ protection (GI-tract), thrombotic events due to loss of vasoprotection and increased propensity for blood coagulation (stroke), acute kidney failure on the basis of loss of kidney protection by prostaglandins together with stress to the organ and/or drugs interfering with the renal blood flow. Acute liver toxicity is typical for acetaminophen. Whether the risk is increased by other hepatotoxic drugs, as diclofenac, is uncertain at present. All risks can be reduced considerably by avoiding problematic drug interactions.
AB - Non-steroidal, anti-inflammatory drugs are the most widely used remedies worldwide. Drug interactions are frequent, life threatening ones are rare: Bleeds on the basis of inhibition of platelet aggregation and loss of organ protection (GI-tract), thrombotic events due to loss of vasoprotection and increased propensity for blood coagulation (stroke), acute kidney failure on the basis of loss of kidney protection by prostaglandins together with stress to the organ and/or drugs interfering with the renal blood flow. Acute liver toxicity is typical for acetaminophen. Whether the risk is increased by other hepatotoxic drugs, as diclofenac, is uncertain at present. All risks can be reduced considerably by avoiding problematic drug interactions.
KW - Humans
KW - Cyclooxygenase Inhibitors adverse effects
KW - Hemorrhage chemically induced
KW - Intestinal Perforation chemically induced
KW - Kidney drug effects
KW - Kidney Failure chemically induced
KW - Liver drug effects
KW - Liver Failure chemically induced
KW - Platelet Aggregation drug effects
KW - Thromboembolism chemically induced
KW - Humans
KW - Cyclooxygenase Inhibitors adverse effects
KW - Hemorrhage chemically induced
KW - Intestinal Perforation chemically induced
KW - Kidney drug effects
KW - Kidney Failure chemically induced
KW - Liver drug effects
KW - Liver Failure chemically induced
KW - Platelet Aggregation drug effects
KW - Thromboembolism chemically induced
M3 - SCORING: Zeitschriftenaufsatz
VL - 134
SP - 1771
EP - 1773
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 36
M1 - 36
ER -