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Cutting edge

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Cutting edge : role of B lymphocytes in protective immunity against Salmonella typhimurium infection. / Mittrücker, H W; Raupach, B; Köhler, A; Kaufmann, S H.

in: J IMMUNOL, Jahrgang 164, Nr. 4, 15.02.2000, S. 1648-52.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mittrücker, HW, Raupach, B, Köhler, A & Kaufmann, SH 2000, 'Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection', J IMMUNOL, Jg. 164, Nr. 4, S. 1648-52.

APA

Mittrücker, H. W., Raupach, B., Köhler, A., & Kaufmann, S. H. (2000). Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection. J IMMUNOL, 164(4), 1648-52.

Vancouver

Mittrücker HW, Raupach B, Köhler A, Kaufmann SH. Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection. J IMMUNOL. 2000 Feb 15;164(4):1648-52.

Bibtex

@article{3e9279ec10284e9492a439e7f8609e7c,
title = "Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection",
abstract = "Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Igmu-/- mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Igmu+/+ mice, LD50 values in Igmu-/- mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Igmu-/- mice cleared attenuated aroA- S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice.",
keywords = "Administration, Oral, Animals, Antibodies, Bacterial, B-Lymphocytes, Immunoglobulin mu-Chains, Injections, Intravenous, Lethal Dose 50, Lymphopenia, Mice, Mice, Inbred C57BL, Mice, Knockout, Salmonella Infections, Animal, Salmonella typhimurium, Typhoid Fever, Typhoid-Paratyphoid Vaccines, Vaccines, Attenuated, Virulence",
author = "Mittr{\"u}cker, {H W} and B Raupach and A K{\"o}hler and Kaufmann, {S H}",
year = "2000",
month = feb,
day = "15",
language = "English",
volume = "164",
pages = "1648--52",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "4",

}

RIS

TY - JOUR

T1 - Cutting edge

T2 - role of B lymphocytes in protective immunity against Salmonella typhimurium infection

AU - Mittrücker, H W

AU - Raupach, B

AU - Köhler, A

AU - Kaufmann, S H

PY - 2000/2/15

Y1 - 2000/2/15

N2 - Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Igmu-/- mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Igmu+/+ mice, LD50 values in Igmu-/- mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Igmu-/- mice cleared attenuated aroA- S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice.

AB - Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Igmu-/- mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Igmu+/+ mice, LD50 values in Igmu-/- mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Igmu-/- mice cleared attenuated aroA- S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice.

KW - Administration, Oral

KW - Animals

KW - Antibodies, Bacterial

KW - B-Lymphocytes

KW - Immunoglobulin mu-Chains

KW - Injections, Intravenous

KW - Lethal Dose 50

KW - Lymphopenia

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Salmonella Infections, Animal

KW - Salmonella typhimurium

KW - Typhoid Fever

KW - Typhoid-Paratyphoid Vaccines

KW - Vaccines, Attenuated

KW - Virulence

M3 - SCORING: Journal article

C2 - 10657605

VL - 164

SP - 1648

EP - 1652

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 4

ER -