Contemporary update of SPECT tracers and novelties in radioguided surgery: a perspective based on urology
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Contemporary update of SPECT tracers and novelties in radioguided surgery: a perspective based on urology. / Würnschimmel, Christoph; Wenzel, Mike; Maurer, Tobias; Valdés Olmos, Renato A; Vidal-Sicart, Sergi.
in: Q J NUCL MED MOL IM, Jahrgang 65, Nr. 3, 09.2021, S. 215-228.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Contemporary update of SPECT tracers and novelties in radioguided surgery: a perspective based on urology
AU - Würnschimmel, Christoph
AU - Wenzel, Mike
AU - Maurer, Tobias
AU - Valdés Olmos, Renato A
AU - Vidal-Sicart, Sergi
PY - 2021/9
Y1 - 2021/9
N2 - Recent technical advances and implementation of novel radiotracers have further increased the potential of radioguided surgery for a broad variety of malignancies. Indeed, the possibilities for future applications of novel radiotracers in diverse oncological strategies has become more promising than ever. This literature review aims to provide a contemporary update on a selected group of radiotracers and evaluates the usability of radioguided surgery and sentinel node procedures, focusing on most promising advances. For example, the impact of targeted radiotracers on prostate specific membrane antigen (PSMA), CD206 receptor-targeted agents (99mTc-tilmanocept), and hybrid tracers adding fluorescence to radioguidance (ICG-99mTc-nanocolloid) as well as targeting hypoxia-induced carbonic anhydrase IX (CAIX) will be covered. Furthermore, future outlooks on the implementation of gold nanoparticles (AuNP's), but also technical advances in improved radiotracer detection by hybrid gamma devices will be discussed.
AB - Recent technical advances and implementation of novel radiotracers have further increased the potential of radioguided surgery for a broad variety of malignancies. Indeed, the possibilities for future applications of novel radiotracers in diverse oncological strategies has become more promising than ever. This literature review aims to provide a contemporary update on a selected group of radiotracers and evaluates the usability of radioguided surgery and sentinel node procedures, focusing on most promising advances. For example, the impact of targeted radiotracers on prostate specific membrane antigen (PSMA), CD206 receptor-targeted agents (99mTc-tilmanocept), and hybrid tracers adding fluorescence to radioguidance (ICG-99mTc-nanocolloid) as well as targeting hypoxia-induced carbonic anhydrase IX (CAIX) will be covered. Furthermore, future outlooks on the implementation of gold nanoparticles (AuNP's), but also technical advances in improved radiotracer detection by hybrid gamma devices will be discussed.
KW - Gold
KW - Humans
KW - Indocyanine Green
KW - Male
KW - Metal Nanoparticles
KW - Sentinel Lymph Node Biopsy
KW - Surgery, Computer-Assisted
KW - Tomography, Emission-Computed, Single-Photon
KW - Urology
U2 - 10.23736/S1824-4785.21.03345-8
DO - 10.23736/S1824-4785.21.03345-8
M3 - SCORING: Review article
C2 - 33829716
VL - 65
SP - 215
EP - 228
JO - Q J NUCL MED MOL IM
JF - Q J NUCL MED MOL IM
SN - 1824-4785
IS - 3
ER -