PortalPublikationenConnectomic comparison of mouse and human cortex

Connectomic comparison of mouse and human cortex

Standard

Connectomic comparison of mouse and human cortex. / Loomba, Sahil; Straehle, Jakob; Gangadharan, Vijayan; Heike, Natalie; Khalifa, Abdelrahman; Motta, Alessandro; Ju, Niansheng; Sievers, Meike; Gempt, Jens; Meyer, Hanno S; Helmstaedter, Moritz.

in: SCIENCE, Jahrgang 377, Nr. 6602, 08.07.2022, S. eabo0924.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Loomba, S, Straehle, J, Gangadharan, V, Heike, N, Khalifa, A, Motta, A, Ju, N, Sievers, M, Gempt, J, Meyer, HS & Helmstaedter, M 2022, 'Connectomic comparison of mouse and human cortex', SCIENCE, Jg. 377, Nr. 6602, S. eabo0924. https://doi.org/10.1126/science.abo0924

APA

Loomba, S., Straehle, J., Gangadharan, V., Heike, N., Khalifa, A., Motta, A., Ju, N., Sievers, M., Gempt, J., Meyer, H. S., & Helmstaedter, M. (2022). Connectomic comparison of mouse and human cortex. SCIENCE, 377(6602), eabo0924. https://doi.org/10.1126/science.abo0924

Vancouver

Loomba S, Straehle J, Gangadharan V, Heike N, Khalifa A, Motta A et al. Connectomic comparison of mouse and human cortex. SCIENCE. 2022 Jul 8;377(6602):eabo0924. https://doi.org/10.1126/science.abo0924

Bibtex

@article{532658320328489da3fa3c6afc0a43fc,
title = "Connectomic comparison of mouse and human cortex",
abstract = "The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex of a mouse, but the possible differences in synaptic circuits between these species are still poorly understood. We used three-dimensional electron microscopy of mouse, macaque, and human cortical samples to study their cell type composition and synaptic circuit architecture. The 2.5-fold increase in interneurons in humans compared with mice was compensated by a change in axonal connection probabilities and therefore did not yield a commensurate increase in inhibitory-versus-excitatory synaptic input balance on human pyramidal cells. Rather, increased inhibition created an expanded interneuron-to-interneuron network, driven by an expansion of interneuron-targeting interneuron types and an increase in their synaptic selectivity for interneuron innervation. These constitute key neuronal network alterations in the human cortex.",
keywords = "Animals, Cerebral Cortex/ultrastructure, Connectome, Humans, Interneurons/ultrastructure, Macaca, Mice, Pyramidal Cells/ultrastructure",
author = "Sahil Loomba and Jakob Straehle and Vijayan Gangadharan and Natalie Heike and Abdelrahman Khalifa and Alessandro Motta and Niansheng Ju and Meike Sievers and Jens Gempt and Meyer, {Hanno S} and Moritz Helmstaedter",
year = "2022",
month = jul,
day = "8",
doi = "10.1126/science.abo0924",
language = "English",
volume = "377",
pages = "eabo0924",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6602",

}

RIS

TY - JOUR

T1 - Connectomic comparison of mouse and human cortex

AU - Loomba, Sahil

AU - Straehle, Jakob

AU - Gangadharan, Vijayan

AU - Heike, Natalie

AU - Khalifa, Abdelrahman

AU - Motta, Alessandro

AU - Ju, Niansheng

AU - Sievers, Meike

AU - Gempt, Jens

AU - Meyer, Hanno S

AU - Helmstaedter, Moritz

PY - 2022/7/8

Y1 - 2022/7/8

N2 - The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex of a mouse, but the possible differences in synaptic circuits between these species are still poorly understood. We used three-dimensional electron microscopy of mouse, macaque, and human cortical samples to study their cell type composition and synaptic circuit architecture. The 2.5-fold increase in interneurons in humans compared with mice was compensated by a change in axonal connection probabilities and therefore did not yield a commensurate increase in inhibitory-versus-excitatory synaptic input balance on human pyramidal cells. Rather, increased inhibition created an expanded interneuron-to-interneuron network, driven by an expansion of interneuron-targeting interneuron types and an increase in their synaptic selectivity for interneuron innervation. These constitute key neuronal network alterations in the human cortex.

AB - The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex of a mouse, but the possible differences in synaptic circuits between these species are still poorly understood. We used three-dimensional electron microscopy of mouse, macaque, and human cortical samples to study their cell type composition and synaptic circuit architecture. The 2.5-fold increase in interneurons in humans compared with mice was compensated by a change in axonal connection probabilities and therefore did not yield a commensurate increase in inhibitory-versus-excitatory synaptic input balance on human pyramidal cells. Rather, increased inhibition created an expanded interneuron-to-interneuron network, driven by an expansion of interneuron-targeting interneuron types and an increase in their synaptic selectivity for interneuron innervation. These constitute key neuronal network alterations in the human cortex.

KW - Animals

KW - Cerebral Cortex/ultrastructure

KW - Connectome

KW - Humans

KW - Interneurons/ultrastructure

KW - Macaca

KW - Mice

KW - Pyramidal Cells/ultrastructure

U2 - 10.1126/science.abo0924

DO - 10.1126/science.abo0924

M3 - SCORING: Journal article

C2 - 35737810

VL - 377

SP - eabo0924

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6602

ER -