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Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies

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Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies. / Nyholt, Dale R; Anttila, Verneri; Winsvold, Bendik S; Kurth, Tobias; Stefansson, Hreinn; Kallela, Mikko; Malik, Rainer; Vries, Boukje de; Terwindt, Gisela M; Ikram, M Arfan; Stam, Anine H; Ligthart, Lannie; Freilinger, Tobias; Alexander, Michael; Muller-Myhsok, Bertram; Schreiber, Stefan; Meitinger, Thomas; Aromaa, Arpo; Eriksson, Johan G; Kaprio, Jaakko; Boomsma, Dorret I; Duijn, Cornelia van; Raitakari, Olli; Järvelin, Marjo-Riitta; Zwart, John-Anker; Quaye, Lydia; Strachan, David P; Kubisch, Christian; Ferrari, Michel D; van den Maagdenberg, Arn M J M; Dichgans, Martin; Wessman, Maija; Smith, George Davey; Stefansson, Kari; Chasman, Daniel I; Palotie, Aarno.

in: CEPHALALGIA, Jahrgang 35, Nr. 6, 05.2015, S. 489-99.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Nyholt, DR, Anttila, V, Winsvold, BS, Kurth, T, Stefansson, H, Kallela, M, Malik, R, Vries, BD, Terwindt, GM, Ikram, MA, Stam, AH, Ligthart, L, Freilinger, T, Alexander, M, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Aromaa, A, Eriksson, JG, Kaprio, J, Boomsma, DI, Duijn, CV, Raitakari, O, Järvelin, M-R, Zwart, J-A, Quaye, L, Strachan, DP, Kubisch, C, Ferrari, MD, van den Maagdenberg, AMJM, Dichgans, M, Wessman, M, Smith, GD, Stefansson, K, Chasman, DI & Palotie, A 2015, 'Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies', CEPHALALGIA, Jg. 35, Nr. 6, S. 489-99. https://doi.org/10.1177/0333102414547784

APA

Nyholt, D. R., Anttila, V., Winsvold, B. S., Kurth, T., Stefansson, H., Kallela, M., Malik, R., Vries, B. D., Terwindt, G. M., Ikram, M. A., Stam, A. H., Ligthart, L., Freilinger, T., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Aromaa, A., Eriksson, J. G., ... Palotie, A. (2015). Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies. CEPHALALGIA, 35(6), 489-99. https://doi.org/10.1177/0333102414547784

Vancouver

Nyholt DR, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M et al. Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies. CEPHALALGIA. 2015 Mai;35(6):489-99. https://doi.org/10.1177/0333102414547784

Bibtex

@article{cd5eea102a374d15abb4c0d41fb5eba6,
title = "Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies",
abstract = "BACKGROUND: There has been intensive debate whether migraine with aura (MA) and migraine without aura (MO) should be considered distinct subtypes or part of the same disease spectrum. There is also discussion to what extent migraine cases collected in specialised headache clinics differ from cases from population cohorts, and how female cases differ from male cases with respect to their migraine. To assess the genetic overlap between these migraine subgroups, we examined genome-wide association (GWA) results from analysis of 23,285 migraine cases and 95,425 population-matched controls.METHODS: Detailed heterogeneity analysis of single-nucleotide polymorphism (SNP) effects (odds ratios) between migraine subgroups was performed for the 12 independent SNP loci significantly associated (p < 5 × 10(-8); thus surpassing the threshold for genome-wide significance) with migraine susceptibility. Overall genetic overlap was assessed using SNP effect concordance analysis (SECA) at over 23,000 independent SNPs.RESULTS: Significant heterogeneity of SNP effects (p het < 1.4 × 10(-3)) was observed between the MA and MO subgroups (for SNP rs9349379), and between the clinic- and population-based subgroups (for SNPs rs10915437, rs6790925 and rs6478241). However, for all 12 SNPs the risk-increasing allele was the same, and SECA found the majority of genome-wide SNP effects to be in the same direction across the subgroups.CONCLUSIONS: Any differences in common genetic risk across these subgroups are outweighed by the similarities. Meta-analysis of additional migraine GWA datasets, regardless of their major subgroup composition, will identify new susceptibility loci for migraine.",
author = "Nyholt, {Dale R} and Verneri Anttila and Winsvold, {Bendik S} and Tobias Kurth and Hreinn Stefansson and Mikko Kallela and Rainer Malik and Vries, {Boukje de} and Terwindt, {Gisela M} and Ikram, {M Arfan} and Stam, {Anine H} and Lannie Ligthart and Tobias Freilinger and Michael Alexander and Bertram Muller-Myhsok and Stefan Schreiber and Thomas Meitinger and Arpo Aromaa and Eriksson, {Johan G} and Jaakko Kaprio and Boomsma, {Dorret I} and Duijn, {Cornelia van} and Olli Raitakari and Marjo-Riitta J{\"a}rvelin and John-Anker Zwart and Lydia Quaye and Strachan, {David P} and Christian Kubisch and Ferrari, {Michel D} and {van den Maagdenberg}, {Arn M J M} and Martin Dichgans and Maija Wessman and Smith, {George Davey} and Kari Stefansson and Chasman, {Daniel I} and Aarno Palotie",
note = "{\textcopyright} International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.",
year = "2015",
month = may,
doi = "10.1177/0333102414547784",
language = "English",
volume = "35",
pages = "489--99",
journal = "CEPHALALGIA",
issn = "0333-1024",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies

AU - Nyholt, Dale R

AU - Anttila, Verneri

AU - Winsvold, Bendik S

AU - Kurth, Tobias

AU - Stefansson, Hreinn

AU - Kallela, Mikko

AU - Malik, Rainer

AU - Vries, Boukje de

AU - Terwindt, Gisela M

AU - Ikram, M Arfan

AU - Stam, Anine H

AU - Ligthart, Lannie

AU - Freilinger, Tobias

AU - Alexander, Michael

AU - Muller-Myhsok, Bertram

AU - Schreiber, Stefan

AU - Meitinger, Thomas

AU - Aromaa, Arpo

AU - Eriksson, Johan G

AU - Kaprio, Jaakko

AU - Boomsma, Dorret I

AU - Duijn, Cornelia van

AU - Raitakari, Olli

AU - Järvelin, Marjo-Riitta

AU - Zwart, John-Anker

AU - Quaye, Lydia

AU - Strachan, David P

AU - Kubisch, Christian

AU - Ferrari, Michel D

AU - van den Maagdenberg, Arn M J M

AU - Dichgans, Martin

AU - Wessman, Maija

AU - Smith, George Davey

AU - Stefansson, Kari

AU - Chasman, Daniel I

AU - Palotie, Aarno

N1 - © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: There has been intensive debate whether migraine with aura (MA) and migraine without aura (MO) should be considered distinct subtypes or part of the same disease spectrum. There is also discussion to what extent migraine cases collected in specialised headache clinics differ from cases from population cohorts, and how female cases differ from male cases with respect to their migraine. To assess the genetic overlap between these migraine subgroups, we examined genome-wide association (GWA) results from analysis of 23,285 migraine cases and 95,425 population-matched controls.METHODS: Detailed heterogeneity analysis of single-nucleotide polymorphism (SNP) effects (odds ratios) between migraine subgroups was performed for the 12 independent SNP loci significantly associated (p < 5 × 10(-8); thus surpassing the threshold for genome-wide significance) with migraine susceptibility. Overall genetic overlap was assessed using SNP effect concordance analysis (SECA) at over 23,000 independent SNPs.RESULTS: Significant heterogeneity of SNP effects (p het < 1.4 × 10(-3)) was observed between the MA and MO subgroups (for SNP rs9349379), and between the clinic- and population-based subgroups (for SNPs rs10915437, rs6790925 and rs6478241). However, for all 12 SNPs the risk-increasing allele was the same, and SECA found the majority of genome-wide SNP effects to be in the same direction across the subgroups.CONCLUSIONS: Any differences in common genetic risk across these subgroups are outweighed by the similarities. Meta-analysis of additional migraine GWA datasets, regardless of their major subgroup composition, will identify new susceptibility loci for migraine.

AB - BACKGROUND: There has been intensive debate whether migraine with aura (MA) and migraine without aura (MO) should be considered distinct subtypes or part of the same disease spectrum. There is also discussion to what extent migraine cases collected in specialised headache clinics differ from cases from population cohorts, and how female cases differ from male cases with respect to their migraine. To assess the genetic overlap between these migraine subgroups, we examined genome-wide association (GWA) results from analysis of 23,285 migraine cases and 95,425 population-matched controls.METHODS: Detailed heterogeneity analysis of single-nucleotide polymorphism (SNP) effects (odds ratios) between migraine subgroups was performed for the 12 independent SNP loci significantly associated (p < 5 × 10(-8); thus surpassing the threshold for genome-wide significance) with migraine susceptibility. Overall genetic overlap was assessed using SNP effect concordance analysis (SECA) at over 23,000 independent SNPs.RESULTS: Significant heterogeneity of SNP effects (p het < 1.4 × 10(-3)) was observed between the MA and MO subgroups (for SNP rs9349379), and between the clinic- and population-based subgroups (for SNPs rs10915437, rs6790925 and rs6478241). However, for all 12 SNPs the risk-increasing allele was the same, and SECA found the majority of genome-wide SNP effects to be in the same direction across the subgroups.CONCLUSIONS: Any differences in common genetic risk across these subgroups are outweighed by the similarities. Meta-analysis of additional migraine GWA datasets, regardless of their major subgroup composition, will identify new susceptibility loci for migraine.

U2 - 10.1177/0333102414547784

DO - 10.1177/0333102414547784

M3 - SCORING: Journal article

C2 - 25179292

VL - 35

SP - 489

EP - 499

JO - CEPHALALGIA

JF - CEPHALALGIA

SN - 0333-1024

IS - 6

ER -