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COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents

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COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents. / Millenet, Sabina K; Nees, Frauke; Heintz, Stefan; Bach, Christiane; Frank, Josef; Vollstädt-Klein, Sabine; Bokde, Arun; Bromberg, Uli; Büchel, Christian; Quinlan, Erin B; Desrivières, Sylvane; Fröhner, Juliane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Lemaire, Herve; Martinot, Jean-Luc; Martinot, Marie-Laure P; Papadoulos, Dimitri O; Paus, Tomáš; Poustka, Luise; Rietschel, Marcella; Smolka, Michael N; Walter, Henrik; Whelan, Rob; Schumann, Gunter; Banaschewski, Tobias; Hohmann, Sarah.

in: FRONT GENET, Jahrgang 9, 2018, S. 284.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Millenet, SK, Nees, F, Heintz, S, Bach, C, Frank, J, Vollstädt-Klein, S, Bokde, A, Bromberg, U, Büchel, C, Quinlan, EB, Desrivières, S, Fröhner, J, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lemaire, H, Martinot, J-L, Martinot, M-LP, Papadoulos, DO, Paus, T, Poustka, L, Rietschel, M, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Banaschewski, T & Hohmann, S 2018, 'COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents', FRONT GENET, Jg. 9, S. 284. https://doi.org/10.3389/fgene.2018.00284

APA

Millenet, S. K., Nees, F., Heintz, S., Bach, C., Frank, J., Vollstädt-Klein, S., Bokde, A., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Fröhner, J., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaire, H., ... Hohmann, S. (2018). COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents. FRONT GENET, 9, 284. https://doi.org/10.3389/fgene.2018.00284

Vancouver

Millenet SK, Nees F, Heintz S, Bach C, Frank J, Vollstädt-Klein S et al. COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents. FRONT GENET. 2018;9:284. https://doi.org/10.3389/fgene.2018.00284

Bibtex

@article{c58523359d76469f8bfcde70fa9ddaea,
title = "COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents",
abstract = "The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16-17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals.",
author = "Millenet, {Sabina K} and Frauke Nees and Stefan Heintz and Christiane Bach and Josef Frank and Sabine Vollst{\"a}dt-Klein and Arun Bokde and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin B} and Sylvane Desrivi{\`e}res and Juliane Fr{\"o}hner and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Herve Lemaire and Jean-Luc Martinot and Martinot, {Marie-Laure P} and Papadoulos, {Dimitri O} and Tom{\'a}{\v s} Paus and Luise Poustka and Marcella Rietschel and Smolka, {Michael N} and Henrik Walter and Rob Whelan and Gunter Schumann and Tobias Banaschewski and Sarah Hohmann",
year = "2018",
doi = "10.3389/fgene.2018.00284",
language = "English",
volume = "9",
pages = "284",
journal = "FRONT GENET",
issn = "1664-8021",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents

AU - Millenet, Sabina K

AU - Nees, Frauke

AU - Heintz, Stefan

AU - Bach, Christiane

AU - Frank, Josef

AU - Vollstädt-Klein, Sabine

AU - Bokde, Arun

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin B

AU - Desrivières, Sylvane

AU - Fröhner, Juliane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lemaire, Herve

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure P

AU - Papadoulos, Dimitri O

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Rob

AU - Schumann, Gunter

AU - Banaschewski, Tobias

AU - Hohmann, Sarah

PY - 2018

Y1 - 2018

N2 - The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16-17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals.

AB - The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16-17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals.

U2 - 10.3389/fgene.2018.00284

DO - 10.3389/fgene.2018.00284

M3 - SCORING: Journal article

C2 - 30108607

VL - 9

SP - 284

JO - FRONT GENET

JF - FRONT GENET

SN - 1664-8021

ER -