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Compartment specific expression of dendritic cell markers in human glomerulonephritis

Standard

Compartment specific expression of dendritic cell markers in human glomerulonephritis. / Segerer, S; Heller, F; Lindenmeyer, M T; Schmid, H; Cohen, C D; Draganovici, D; Mandelbaum, J; Nelson, P J; Gröne, H-J; Gröne, E F; Figel, A-M; Nössner, E; Schlöndorff, D.

in: KIDNEY INT, Jahrgang 74, Nr. 1, 07.2008, S. 37-46.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Segerer, S, Heller, F, Lindenmeyer, MT, Schmid, H, Cohen, CD, Draganovici, D, Mandelbaum, J, Nelson, PJ, Gröne, H-J, Gröne, EF, Figel, A-M, Nössner, E & Schlöndorff, D 2008, 'Compartment specific expression of dendritic cell markers in human glomerulonephritis', KIDNEY INT, Jg. 74, Nr. 1, S. 37-46. https://doi.org/10.1038/ki.2008.99

APA

Segerer, S., Heller, F., Lindenmeyer, M. T., Schmid, H., Cohen, C. D., Draganovici, D., Mandelbaum, J., Nelson, P. J., Gröne, H-J., Gröne, E. F., Figel, A-M., Nössner, E., & Schlöndorff, D. (2008). Compartment specific expression of dendritic cell markers in human glomerulonephritis. KIDNEY INT, 74(1), 37-46. https://doi.org/10.1038/ki.2008.99

Vancouver

Segerer S, Heller F, Lindenmeyer MT, Schmid H, Cohen CD, Draganovici D et al. Compartment specific expression of dendritic cell markers in human glomerulonephritis. KIDNEY INT. 2008 Jul;74(1):37-46. https://doi.org/10.1038/ki.2008.99

Bibtex

@article{36279465f6e844068aac59da697024a7,
title = "Compartment specific expression of dendritic cell markers in human glomerulonephritis",
abstract = "Macrophages and dendritic cells are heterogenous and highly plastic bone marrow-derived cells that play major roles in renal diseases. We characterized these cells using immunohistochemistry in 55 renal biopsies from control patients or patients with glomerulonephritis as an initial step towards postulating specific roles for these cells in kidney disease. In proliferative glomerulonephritis numerous CD68 positive (pan monocyte, macrophage and dendritic marker) cells were found in both glomeruli and the tubulointerstitial space, however, a myeloid dendritic cell marker (DC-SIGN) was identified only in the tubulointerstitium. A significant number of plasmacytoid dendritic cells (identified as BDCA-2 positive cells) were seen at sites of interstitial inflammation, including follicular aggregates of inflammatory cells. Langerin positive cells (a marker of Langerhans' cells) were detectable but rare. The area of either CD68 or DC-SIGN positive interstitial cells correlated with serum creatinine. Low levels of DC-SIGN, DC-LAMP and MHC class II mRNA were present in the tubulointerstitial space in controls and increased only in that region in proliferative glomerulonephritis. We demonstrate that the CD68 positive cells infiltrating the glomerulus lack dendritic cell markers (reflecting macrophages), whereas in the tubulointerstitial space the majority of CD68 positive cells are also DC-SIGN positive (reflecting myeloid dendritic cells). Their number correlated with serum creatinine, which further emphasizes the significance of interstitial DCs in progressive glomerular diseases.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Biomarkers, Case-Control Studies, Cell Adhesion Molecules, Cell Movement, Dendritic Cells, Disease Progression, Glomerulonephritis, Humans, Immunohistochemistry, Immunophenotyping, Inflammation, Kidney Glomerulus, Lectins, C-Type, Middle Aged, Receptors, Cell Surface, Journal Article, Research Support, Non-U.S. Gov't",
author = "S Segerer and F Heller and Lindenmeyer, {M T} and H Schmid and Cohen, {C D} and D Draganovici and J Mandelbaum and Nelson, {P J} and H-J Gr{\"o}ne and Gr{\"o}ne, {E F} and A-M Figel and E N{\"o}ssner and D Schl{\"o}ndorff",
year = "2008",
month = jul,
doi = "10.1038/ki.2008.99",
language = "English",
volume = "74",
pages = "37--46",
journal = "KIDNEY INT",
issn = "0085-2538",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Compartment specific expression of dendritic cell markers in human glomerulonephritis

AU - Segerer, S

AU - Heller, F

AU - Lindenmeyer, M T

AU - Schmid, H

AU - Cohen, C D

AU - Draganovici, D

AU - Mandelbaum, J

AU - Nelson, P J

AU - Gröne, H-J

AU - Gröne, E F

AU - Figel, A-M

AU - Nössner, E

AU - Schlöndorff, D

PY - 2008/7

Y1 - 2008/7

N2 - Macrophages and dendritic cells are heterogenous and highly plastic bone marrow-derived cells that play major roles in renal diseases. We characterized these cells using immunohistochemistry in 55 renal biopsies from control patients or patients with glomerulonephritis as an initial step towards postulating specific roles for these cells in kidney disease. In proliferative glomerulonephritis numerous CD68 positive (pan monocyte, macrophage and dendritic marker) cells were found in both glomeruli and the tubulointerstitial space, however, a myeloid dendritic cell marker (DC-SIGN) was identified only in the tubulointerstitium. A significant number of plasmacytoid dendritic cells (identified as BDCA-2 positive cells) were seen at sites of interstitial inflammation, including follicular aggregates of inflammatory cells. Langerin positive cells (a marker of Langerhans' cells) were detectable but rare. The area of either CD68 or DC-SIGN positive interstitial cells correlated with serum creatinine. Low levels of DC-SIGN, DC-LAMP and MHC class II mRNA were present in the tubulointerstitial space in controls and increased only in that region in proliferative glomerulonephritis. We demonstrate that the CD68 positive cells infiltrating the glomerulus lack dendritic cell markers (reflecting macrophages), whereas in the tubulointerstitial space the majority of CD68 positive cells are also DC-SIGN positive (reflecting myeloid dendritic cells). Their number correlated with serum creatinine, which further emphasizes the significance of interstitial DCs in progressive glomerular diseases.

AB - Macrophages and dendritic cells are heterogenous and highly plastic bone marrow-derived cells that play major roles in renal diseases. We characterized these cells using immunohistochemistry in 55 renal biopsies from control patients or patients with glomerulonephritis as an initial step towards postulating specific roles for these cells in kidney disease. In proliferative glomerulonephritis numerous CD68 positive (pan monocyte, macrophage and dendritic marker) cells were found in both glomeruli and the tubulointerstitial space, however, a myeloid dendritic cell marker (DC-SIGN) was identified only in the tubulointerstitium. A significant number of plasmacytoid dendritic cells (identified as BDCA-2 positive cells) were seen at sites of interstitial inflammation, including follicular aggregates of inflammatory cells. Langerin positive cells (a marker of Langerhans' cells) were detectable but rare. The area of either CD68 or DC-SIGN positive interstitial cells correlated with serum creatinine. Low levels of DC-SIGN, DC-LAMP and MHC class II mRNA were present in the tubulointerstitial space in controls and increased only in that region in proliferative glomerulonephritis. We demonstrate that the CD68 positive cells infiltrating the glomerulus lack dendritic cell markers (reflecting macrophages), whereas in the tubulointerstitial space the majority of CD68 positive cells are also DC-SIGN positive (reflecting myeloid dendritic cells). Their number correlated with serum creatinine, which further emphasizes the significance of interstitial DCs in progressive glomerular diseases.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD

KW - Antigens, Differentiation, Myelomonocytic

KW - Biomarkers

KW - Case-Control Studies

KW - Cell Adhesion Molecules

KW - Cell Movement

KW - Dendritic Cells

KW - Disease Progression

KW - Glomerulonephritis

KW - Humans

KW - Immunohistochemistry

KW - Immunophenotyping

KW - Inflammation

KW - Kidney Glomerulus

KW - Lectins, C-Type

KW - Middle Aged

KW - Receptors, Cell Surface

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ki.2008.99

DO - 10.1038/ki.2008.99

M3 - SCORING: Journal article

C2 - 18368027

VL - 74

SP - 37

EP - 46

JO - KIDNEY INT

JF - KIDNEY INT

SN - 0085-2538

IS - 1

ER -