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Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice.

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Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice. / Peng, Su-Ping; Kügler, Sebastian; Ma, Zhi-Kui; Shen, Yan-Qin; Schachner, Melitta.

in: NEUROREPORT, Jahrgang 22, Nr. 12, 12, 2011, S. 565-569.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Peng, S-P, Kügler, S, Ma, Z-K, Shen, Y-Q & Schachner, M 2011, 'Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice.', NEUROREPORT, Jg. 22, Nr. 12, 12, S. 565-569. <http://www.ncbi.nlm.nih.gov/pubmed/21879483?dopt=Citation>

APA

Peng, S-P., Kügler, S., Ma, Z-K., Shen, Y-Q., & Schachner, M. (2011). Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice. NEUROREPORT, 22(12), 565-569. [12]. http://www.ncbi.nlm.nih.gov/pubmed/21879483?dopt=Citation

Vancouver

Peng S-P, Kügler S, Ma Z-K, Shen Y-Q, Schachner M. Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice. NEUROREPORT. 2011;22(12):565-569. 12.

Bibtex

@article{60c9e8f018484f108a3ead6802fd1b12,
title = "Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice.",
abstract = "Recombinant adeno-associated virus (AAV) vectors are promising tools for gene therapy. In spinal cord injury where extensive damage occurs, vectors with high diffusion and transduction abilities are required. We compared the diffusion capacity and transduction efficiency of AAV2 and AAV5 vectors using a mouse spinal cord injury model. Our study demonstrates that AAV5 is more effective than AAV2 for delivering genes into the injured spinal cord tissue. AAV5 diffused 6.9 mm from the injection site, transduced with an approximately two-fold increase in total cell number and yielded an approximately three-fold increase in gene expression in comparison with AAV2.",
keywords = "Animals, Female, Mice, Mice, Inbred C57BL, Transduction, Genetic, Dependovirus/*genetics, Gene Therapy/*methods, Genetic Vectors/*genetics/*therapeutic use, Spinal Cord Injuries/*therapy, *Transgenes, Animals, Female, Mice, Mice, Inbred C57BL, Transduction, Genetic, Dependovirus/*genetics, Gene Therapy/*methods, Genetic Vectors/*genetics/*therapeutic use, Spinal Cord Injuries/*therapy, *Transgenes",
author = "Su-Ping Peng and Sebastian K{\"u}gler and Zhi-Kui Ma and Yan-Qin Shen and Melitta Schachner",
year = "2011",
language = "English",
volume = "22",
pages = "565--569",
journal = "NEUROREPORT",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice.

AU - Peng, Su-Ping

AU - Kügler, Sebastian

AU - Ma, Zhi-Kui

AU - Shen, Yan-Qin

AU - Schachner, Melitta

PY - 2011

Y1 - 2011

N2 - Recombinant adeno-associated virus (AAV) vectors are promising tools for gene therapy. In spinal cord injury where extensive damage occurs, vectors with high diffusion and transduction abilities are required. We compared the diffusion capacity and transduction efficiency of AAV2 and AAV5 vectors using a mouse spinal cord injury model. Our study demonstrates that AAV5 is more effective than AAV2 for delivering genes into the injured spinal cord tissue. AAV5 diffused 6.9 mm from the injection site, transduced with an approximately two-fold increase in total cell number and yielded an approximately three-fold increase in gene expression in comparison with AAV2.

AB - Recombinant adeno-associated virus (AAV) vectors are promising tools for gene therapy. In spinal cord injury where extensive damage occurs, vectors with high diffusion and transduction abilities are required. We compared the diffusion capacity and transduction efficiency of AAV2 and AAV5 vectors using a mouse spinal cord injury model. Our study demonstrates that AAV5 is more effective than AAV2 for delivering genes into the injured spinal cord tissue. AAV5 diffused 6.9 mm from the injection site, transduced with an approximately two-fold increase in total cell number and yielded an approximately three-fold increase in gene expression in comparison with AAV2.

KW - Animals

KW - Female

KW - Mice

KW - Mice, Inbred C57BL

KW - Transduction, Genetic

KW - Dependovirus/genetics

KW - Gene Therapy/methods

KW - Genetic Vectors/genetics/therapeutic use

KW - Spinal Cord Injuries/therapy

KW - Transgenes

KW - Animals

KW - Female

KW - Mice

KW - Mice, Inbred C57BL

KW - Transduction, Genetic

KW - Dependovirus/genetics

KW - Gene Therapy/methods

KW - Genetic Vectors/genetics/therapeutic use

KW - Spinal Cord Injuries/therapy

KW - Transgenes

M3 - SCORING: Journal article

VL - 22

SP - 565

EP - 569

JO - NEUROREPORT

JF - NEUROREPORT

SN - 0959-4965

IS - 12

M1 - 12

ER -