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Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice

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Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. / Schob, Claudia; Morellini, Fabio; Ohana, Ora; Bakota, Lidia; Hrynchak, Mariya V; Brandt, Roland; Brockmann, Marco D; Cichon, Nicole; Hartung, Henrike; Hanganu-Opatz, Ileana L; Kraus, Vanessa; Scharf, Sarah; Herrmans-Borgmeyer, Irm; Schweizer, Michaela; Kuhl, Dietmar; Wöhr, Markus; Vörckel, Karl J; Calzada-Wack, Julia; Fuchs, Helmut; Gailus-Durner, Valérie; Hrabě de Angelis, Martin; Garner, Craig C; Kreienkamp, Hans-Jürgen; Kindler, Stefan.

in: TRANSL PSYCHIAT, Jahrgang 9, Nr. 1, 16.01.2019, S. 7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schob, C, Morellini, F, Ohana, O, Bakota, L, Hrynchak, MV, Brandt, R, Brockmann, MD, Cichon, N, Hartung, H, Hanganu-Opatz, IL, Kraus, V, Scharf, S, Herrmans-Borgmeyer, I, Schweizer, M, Kuhl, D, Wöhr, M, Vörckel, KJ, Calzada-Wack, J, Fuchs, H, Gailus-Durner, V, Hrabě de Angelis, M, Garner, CC, Kreienkamp, H-J & Kindler, S 2019, 'Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice', TRANSL PSYCHIAT, Jg. 9, Nr. 1, S. 7. https://doi.org/10.1038/s41398-018-0327-z

APA

Schob, C., Morellini, F., Ohana, O., Bakota, L., Hrynchak, M. V., Brandt, R., Brockmann, M. D., Cichon, N., Hartung, H., Hanganu-Opatz, I. L., Kraus, V., Scharf, S., Herrmans-Borgmeyer, I., Schweizer, M., Kuhl, D., Wöhr, M., Vörckel, K. J., Calzada-Wack, J., Fuchs, H., ... Kindler, S. (2019). Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. TRANSL PSYCHIAT, 9(1), 7. https://doi.org/10.1038/s41398-018-0327-z

Vancouver

Schob C, Morellini F, Ohana O, Bakota L, Hrynchak MV, Brandt R et al. Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. TRANSL PSYCHIAT. 2019 Jan 16;9(1):7. https://doi.org/10.1038/s41398-018-0327-z

Bibtex

@article{3f95af5a1d814250b21226ac3ff1f51b,
title = "Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice",
abstract = "In humans, genetic variants of DLGAP1-4 have been linked with neuropsychiatric conditions, including autism spectrum disorder (ASD). While these findings implicate the encoded postsynaptic proteins, SAPAP1-4, in the etiology of neuropsychiatric conditions, underlying neurobiological mechanisms are unknown. To assess the contribution of SAPAP4 to these disorders, we characterized SAPAP4-deficient mice. Our study reveals that the loss of SAPAP4 triggers profound behavioural abnormalities, including cognitive deficits combined with impaired vocal communication and social interaction, phenotypes reminiscent of ASD in humans. These behavioural alterations of SAPAP4-deficient mice are associated with dramatic changes in synapse morphology, function and plasticity, indicating that SAPAP4 is critical for the development of functional neuronal networks and that mutations in the corresponding human gene, DLGAP4, may cause deficits in social and cognitive functioning relevant to ASD-like neurodevelopmental disorders.",
keywords = "Journal Article",
author = "Claudia Schob and Fabio Morellini and Ora Ohana and Lidia Bakota and Hrynchak, {Mariya V} and Roland Brandt and Brockmann, {Marco D} and Nicole Cichon and Henrike Hartung and Hanganu-Opatz, {Ileana L} and Vanessa Kraus and Sarah Scharf and Irm Herrmans-Borgmeyer and Michaela Schweizer and Dietmar Kuhl and Markus W{\"o}hr and V{\"o}rckel, {Karl J} and Julia Calzada-Wack and Helmut Fuchs and Val{\'e}rie Gailus-Durner and {Hrab{\v e} de Angelis}, Martin and Garner, {Craig C} and Hans-J{\"u}rgen Kreienkamp and Stefan Kindler",
year = "2019",
month = jan,
day = "16",
doi = "10.1038/s41398-018-0327-z",
language = "English",
volume = "9",
pages = "7",
journal = "TRANSL PSYCHIAT",
issn = "2158-3188",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice

AU - Schob, Claudia

AU - Morellini, Fabio

AU - Ohana, Ora

AU - Bakota, Lidia

AU - Hrynchak, Mariya V

AU - Brandt, Roland

AU - Brockmann, Marco D

AU - Cichon, Nicole

AU - Hartung, Henrike

AU - Hanganu-Opatz, Ileana L

AU - Kraus, Vanessa

AU - Scharf, Sarah

AU - Herrmans-Borgmeyer, Irm

AU - Schweizer, Michaela

AU - Kuhl, Dietmar

AU - Wöhr, Markus

AU - Vörckel, Karl J

AU - Calzada-Wack, Julia

AU - Fuchs, Helmut

AU - Gailus-Durner, Valérie

AU - Hrabě de Angelis, Martin

AU - Garner, Craig C

AU - Kreienkamp, Hans-Jürgen

AU - Kindler, Stefan

PY - 2019/1/16

Y1 - 2019/1/16

N2 - In humans, genetic variants of DLGAP1-4 have been linked with neuropsychiatric conditions, including autism spectrum disorder (ASD). While these findings implicate the encoded postsynaptic proteins, SAPAP1-4, in the etiology of neuropsychiatric conditions, underlying neurobiological mechanisms are unknown. To assess the contribution of SAPAP4 to these disorders, we characterized SAPAP4-deficient mice. Our study reveals that the loss of SAPAP4 triggers profound behavioural abnormalities, including cognitive deficits combined with impaired vocal communication and social interaction, phenotypes reminiscent of ASD in humans. These behavioural alterations of SAPAP4-deficient mice are associated with dramatic changes in synapse morphology, function and plasticity, indicating that SAPAP4 is critical for the development of functional neuronal networks and that mutations in the corresponding human gene, DLGAP4, may cause deficits in social and cognitive functioning relevant to ASD-like neurodevelopmental disorders.

AB - In humans, genetic variants of DLGAP1-4 have been linked with neuropsychiatric conditions, including autism spectrum disorder (ASD). While these findings implicate the encoded postsynaptic proteins, SAPAP1-4, in the etiology of neuropsychiatric conditions, underlying neurobiological mechanisms are unknown. To assess the contribution of SAPAP4 to these disorders, we characterized SAPAP4-deficient mice. Our study reveals that the loss of SAPAP4 triggers profound behavioural abnormalities, including cognitive deficits combined with impaired vocal communication and social interaction, phenotypes reminiscent of ASD in humans. These behavioural alterations of SAPAP4-deficient mice are associated with dramatic changes in synapse morphology, function and plasticity, indicating that SAPAP4 is critical for the development of functional neuronal networks and that mutations in the corresponding human gene, DLGAP4, may cause deficits in social and cognitive functioning relevant to ASD-like neurodevelopmental disorders.

KW - Journal Article

U2 - 10.1038/s41398-018-0327-z

DO - 10.1038/s41398-018-0327-z

M3 - SCORING: Journal article

C2 - 30664629

VL - 9

SP - 7

JO - TRANSL PSYCHIAT

JF - TRANSL PSYCHIAT

SN - 2158-3188

IS - 1

ER -