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Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.

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Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. / Gagliani, Nicola; Magnani, Chiara F; Huber, Samuel; Gianolini, Monica E; Pala, Mauro; Licona-Limon, Paula; Guo, Binggege; Herbert, De'broski R; Bulfone, Alessandro; Trentini, Filippo; Clelia, Di Serio; Bacchetta, Rosa; Andreani, Marco; Brockmann, Leonie; Gregori, Silvia; Flavell, Richard A; Roncarolo, Maria-Grazia.

in: NAT MED, Jahrgang 19, Nr. 6, 6, 2013, S. 739-746.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gagliani, N, Magnani, CF, Huber, S, Gianolini, ME, Pala, M, Licona-Limon, P, Guo, B, Herbert, DR, Bulfone, A, Trentini, F, Clelia, DS, Bacchetta, R, Andreani, M, Brockmann, L, Gregori, S, Flavell, RA & Roncarolo, M-G 2013, 'Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.', NAT MED, Jg. 19, Nr. 6, 6, S. 739-746. <http://www.ncbi.nlm.nih.gov/pubmed/23624599?dopt=Citation>

APA

Gagliani, N., Magnani, C. F., Huber, S., Gianolini, M. E., Pala, M., Licona-Limon, P., Guo, B., Herbert, D. R., Bulfone, A., Trentini, F., Clelia, D. S., Bacchetta, R., Andreani, M., Brockmann, L., Gregori, S., Flavell, R. A., & Roncarolo, M-G. (2013). Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. NAT MED, 19(6), 739-746. [6]. http://www.ncbi.nlm.nih.gov/pubmed/23624599?dopt=Citation

Vancouver

Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. NAT MED. 2013;19(6):739-746. 6.

Bibtex

@article{fca14edf3545416fa6be3041bb08a9a5,
title = "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.",
abstract = "CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healthy volunteers. The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation. The use of these markers makes it feasible to track Tr1 cells in vivo and purify Tr1 cells for cell therapy to induce or restore tolerance in subjects with immune-mediated diseases.",
author = "Nicola Gagliani and Magnani, {Chiara F} and Samuel Huber and Gianolini, {Monica E} and Mauro Pala and Paula Licona-Limon and Binggege Guo and Herbert, {De'broski R} and Alessandro Bulfone and Filippo Trentini and Clelia, {Di Serio} and Rosa Bacchetta and Marco Andreani and Leonie Brockmann and Silvia Gregori and Flavell, {Richard A} and Maria-Grazia Roncarolo",
year = "2013",
language = "English",
volume = "19",
pages = "739--746",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "6",

}

RIS

TY - JOUR

T1 - Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.

AU - Gagliani, Nicola

AU - Magnani, Chiara F

AU - Huber, Samuel

AU - Gianolini, Monica E

AU - Pala, Mauro

AU - Licona-Limon, Paula

AU - Guo, Binggege

AU - Herbert, De'broski R

AU - Bulfone, Alessandro

AU - Trentini, Filippo

AU - Clelia, Di Serio

AU - Bacchetta, Rosa

AU - Andreani, Marco

AU - Brockmann, Leonie

AU - Gregori, Silvia

AU - Flavell, Richard A

AU - Roncarolo, Maria-Grazia

PY - 2013

Y1 - 2013

N2 - CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healthy volunteers. The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation. The use of these markers makes it feasible to track Tr1 cells in vivo and purify Tr1 cells for cell therapy to induce or restore tolerance in subjects with immune-mediated diseases.

AB - CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healthy volunteers. The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation. The use of these markers makes it feasible to track Tr1 cells in vivo and purify Tr1 cells for cell therapy to induce or restore tolerance in subjects with immune-mediated diseases.

M3 - SCORING: Journal article

VL - 19

SP - 739

EP - 746

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 6

M1 - 6

ER -