Chloride accumulation in endosomes and lysosomes: facts checked in mice
Abstract
Loss of the ClC-3 chloride/proton exchanger found in intracellular compartments leads to marked neurodegeneration. New genetic work by Weinert et al (2020) now shows that selective impairment of ClC-3's ion exchange activity is sufficient to elicit this severe phenotype in vivo. ClC-3 cooperates with the closely related ClC-4 in protecting endolysosomal chloride balance and neuronal integrity.
Bibliografische Daten
| Originalsprache | Englisch |
|---|---|
| ISSN | 0261-4189 |
| DOIs | |
| Status | Veröffentlicht - 04.05.2020 |
| Extern publiziert | Ja |
Anmerkungen des Dekanats
© 2020 The Author.
| PubMed | 32270512 |
|---|
