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Changes of acetylcholinesterase molecular forms in regenerating motor neurons

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Changes of acetylcholinesterase molecular forms in regenerating motor neurons. / Engel, A K; Kreutzberg, G W.

in: NEUROSCIENCE, Jahrgang 18, Nr. 2, 01.06.1986, S. 467-73.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Engel, AK & Kreutzberg, GW 1986, 'Changes of acetylcholinesterase molecular forms in regenerating motor neurons', NEUROSCIENCE, Jg. 18, Nr. 2, S. 467-73.

APA

Engel, A. K., & Kreutzberg, G. W. (1986). Changes of acetylcholinesterase molecular forms in regenerating motor neurons. NEUROSCIENCE, 18(2), 467-73.

Vancouver

Engel AK, Kreutzberg GW. Changes of acetylcholinesterase molecular forms in regenerating motor neurons. NEUROSCIENCE. 1986 Jun 1;18(2):467-73.

Bibtex

@article{90562c722f0f4002b608b090bdb3f0cd,
title = "Changes of acetylcholinesterase molecular forms in regenerating motor neurons",
abstract = "Axotomy-induced changes of the molecular forms of acetylcholinesterase in the facial nucleus of the rat and guinea pig were investigated. Evidence is presented that facial motoneurons of the guinea pig are capable of synthesizing considerable amounts of 16S acetylcholinesterase, and furthermore that acetylcholinesterase isoenzymes show species differences in their response to axon transection. Three isoenzymes could be separated by velocity sedimentation, which correspond to G1 (4S), G4 (10S) and A12 (16S) acetylcholinesterase. After axotomy, G4 activity was decreased in both species by 40% 2-3 weeks after nerve transection. In the rat, G1 was even further depressed, whereas in guinea pig facial nucleus G1 showed only a slight change. A12 displayed a clear species difference: in the rat, it was decreased to 60% of control 5 days after axotomy. In guinea pig, however, A12 increased dramatically to values of 400-500% of the unoperated control, and maintained elevated levels even 120 days after operation. This result does not agree with the decrease of transmitter metabolism in regenerating nerves and provides support to the hypothesis that acetylcholinesterase in regenerating nerves may have functions different from transmitter hydrolysis.",
keywords = "Acetylcholinesterase, Animals, Chickens, Facial Nerve, Guinea Pigs, Isoenzymes, Motor Neurons, Nerve Regeneration, Pons, Rats, Species Specificity",
author = "Engel, {A K} and Kreutzberg, {G W}",
year = "1986",
month = jun,
day = "1",
language = "English",
volume = "18",
pages = "467--73",
journal = "NEUROSCIENCE",
issn = "0306-4522",
publisher = "Elsevier Limited",
number = "2",

}

RIS

TY - JOUR

T1 - Changes of acetylcholinesterase molecular forms in regenerating motor neurons

AU - Engel, A K

AU - Kreutzberg, G W

PY - 1986/6/1

Y1 - 1986/6/1

N2 - Axotomy-induced changes of the molecular forms of acetylcholinesterase in the facial nucleus of the rat and guinea pig were investigated. Evidence is presented that facial motoneurons of the guinea pig are capable of synthesizing considerable amounts of 16S acetylcholinesterase, and furthermore that acetylcholinesterase isoenzymes show species differences in their response to axon transection. Three isoenzymes could be separated by velocity sedimentation, which correspond to G1 (4S), G4 (10S) and A12 (16S) acetylcholinesterase. After axotomy, G4 activity was decreased in both species by 40% 2-3 weeks after nerve transection. In the rat, G1 was even further depressed, whereas in guinea pig facial nucleus G1 showed only a slight change. A12 displayed a clear species difference: in the rat, it was decreased to 60% of control 5 days after axotomy. In guinea pig, however, A12 increased dramatically to values of 400-500% of the unoperated control, and maintained elevated levels even 120 days after operation. This result does not agree with the decrease of transmitter metabolism in regenerating nerves and provides support to the hypothesis that acetylcholinesterase in regenerating nerves may have functions different from transmitter hydrolysis.

AB - Axotomy-induced changes of the molecular forms of acetylcholinesterase in the facial nucleus of the rat and guinea pig were investigated. Evidence is presented that facial motoneurons of the guinea pig are capable of synthesizing considerable amounts of 16S acetylcholinesterase, and furthermore that acetylcholinesterase isoenzymes show species differences in their response to axon transection. Three isoenzymes could be separated by velocity sedimentation, which correspond to G1 (4S), G4 (10S) and A12 (16S) acetylcholinesterase. After axotomy, G4 activity was decreased in both species by 40% 2-3 weeks after nerve transection. In the rat, G1 was even further depressed, whereas in guinea pig facial nucleus G1 showed only a slight change. A12 displayed a clear species difference: in the rat, it was decreased to 60% of control 5 days after axotomy. In guinea pig, however, A12 increased dramatically to values of 400-500% of the unoperated control, and maintained elevated levels even 120 days after operation. This result does not agree with the decrease of transmitter metabolism in regenerating nerves and provides support to the hypothesis that acetylcholinesterase in regenerating nerves may have functions different from transmitter hydrolysis.

KW - Acetylcholinesterase

KW - Animals

KW - Chickens

KW - Facial Nerve

KW - Guinea Pigs

KW - Isoenzymes

KW - Motor Neurons

KW - Nerve Regeneration

KW - Pons

KW - Rats

KW - Species Specificity

M3 - SCORING: Journal article

C2 - 3736865

VL - 18

SP - 467

EP - 473

JO - NEUROSCIENCE

JF - NEUROSCIENCE

SN - 0306-4522

IS - 2

ER -