Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors.
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Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors. / Miller, N G; Reddick, W E; Kocak, M; Glass, J O; Löbel, Ulrike; Morris, B; Gajjar, A; Patay, Z.
in: AM J NEURORADIOL, Jahrgang 31, Nr. 2, 2, 2010, S. 288-294.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors.
AU - Miller, N G
AU - Reddick, W E
AU - Kocak, M
AU - Glass, J O
AU - Löbel, Ulrike
AU - Morris, B
AU - Gajjar, A
AU - Patay, Z
PY - 2010
Y1 - 2010
N2 - PFS occurs in approximately 25% of pediatric patients receiving surgery for midline posterior fossa tumors. Increasing evidence suggests that PFS represents a complex supratentorial cortical dysfunction related to surgery-induced disruption of critical cerebellocerebral connections. The purpose of this study was to determine whether a consistent surgical damage pattern may be identified in patients with PFS by early postoperative anatomic imaging analysis of the pECP and to test whether DSC can detect corresponding changes in cerebral cortical perfusion to indicate a secondary, remote functional disturbance, which could suggest a diaschisis-like pathomechanism.
AB - PFS occurs in approximately 25% of pediatric patients receiving surgery for midline posterior fossa tumors. Increasing evidence suggests that PFS represents a complex supratentorial cortical dysfunction related to surgery-induced disruption of critical cerebellocerebral connections. The purpose of this study was to determine whether a consistent surgical damage pattern may be identified in patients with PFS by early postoperative anatomic imaging analysis of the pECP and to test whether DSC can detect corresponding changes in cerebral cortical perfusion to indicate a secondary, remote functional disturbance, which could suggest a diaschisis-like pathomechanism.
KW - Humans
KW - Male
KW - Female
KW - Child
KW - Logistic Models
KW - Child, Preschool
KW - Retrospective Studies
KW - Magnetic Resonance Imaging
KW - Cerebellum pathology
KW - Cerebral Cortex pathology
KW - Syndrome
KW - Cognition Disorders etiology
KW - Cerebellar Neoplasms pathology
KW - Cranial Fossa, Posterior pathology
KW - Neural Pathways pathology
KW - Postoperative Complications etiology
KW - Humans
KW - Male
KW - Female
KW - Child
KW - Logistic Models
KW - Child, Preschool
KW - Retrospective Studies
KW - Magnetic Resonance Imaging
KW - Cerebellum pathology
KW - Cerebral Cortex pathology
KW - Syndrome
KW - Cognition Disorders etiology
KW - Cerebellar Neoplasms pathology
KW - Cranial Fossa, Posterior pathology
KW - Neural Pathways pathology
KW - Postoperative Complications etiology
M3 - SCORING: Zeitschriftenaufsatz
VL - 31
SP - 288
EP - 294
JO - AM J NEURORADIOL
JF - AM J NEURORADIOL
SN - 0195-6108
IS - 2
M1 - 2
ER -