Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

Reto Sutter; O Shakhova; Harivadan Bhagat; H Behesti; Christian Sutter; S Penkar; A C Santuccione; R Bernays; F L Heppner; U Schüller; M A Grotzer; H Moch; P Schraml; S Marino

doi:10.1038/onc.2009.472

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

Standard

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas. / Sutter, Reto; Shakhova, O; Bhagat, Harivadan; Behesti, H; Sutter, Christian; Penkar, S; Santuccione, A C; Bernays, R; Heppner, F L; Schüller, U; Grotzer, M A; Moch, H; Schraml, P; Marino, S.

in: ONCOGENE, Jahrgang 29, Nr. 12, 25.03.2010, S. 1845-56.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sutter, R, Shakhova, O, Bhagat, H, Behesti, H, Sutter, C, Penkar, S, Santuccione, AC, Bernays, R, Heppner, FL, Schüller, U, Grotzer, MA, Moch, H, Schraml, P & Marino, S 2010, 'Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas', ONCOGENE, Jg. 29, Nr. 12, S. 1845-56. https://doi.org/10.1038/onc.2009.472

APA

Sutter, R., Shakhova, O., Bhagat, H., Behesti, H., Sutter, C., Penkar, S., Santuccione, A. C., Bernays, R., Heppner, F. L., Schüller, U., Grotzer, M. A., Moch, H., Schraml, P., & Marino, S. (2010). Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas. ONCOGENE, 29(12), 1845-56. https://doi.org/10.1038/onc.2009.472

Vancouver

Sutter R, Shakhova O, Bhagat H, Behesti H, Sutter C, Penkar S et al. Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas. ONCOGENE. 2010 Mär 25;29(12):1845-56. https://doi.org/10.1038/onc.2009.472

Bibtex

@article{7886352ddb6e41fd849cfcd5dbb919b0,

title = "Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas",

abstract = "Cells with stem cell properties have been isolated from various areas of the postnatal mammalian brain, most recently from the postnatal mouse cerebellum. We show here that inactivation of the tumor suppressor genes Rb and p53 in these endogenous neural stem cells induced deregulated proliferation and resistance to apoptosis in vitro. Moreover, injection of these cells into mice formed medulloblastomas. Medulloblastomas are the most common malignant brain tumors of childhood, and despite recent advances in treatment they are associated with high morbidity and mortality. They are highly heterogeneous tumors characterized by a diverse genetic make-up and expression profile as well as variable prognosis. Here, we describe a novel ontogenetic pathway of medulloblastoma that significantly contributes to understanding their heterogeneity. Experimental medulloblastomas originating from neural stem cells preferentially expressed stem cell markers Nestin, Sox2 and Sox9, which were not expressed in medulloblastomas originating from granule-cell-restricted progenitors. Furthermore, the expression of these markers identified a subset of human medulloblastomas associated with a poorer clinical outcome.",

keywords = "Animals, Cerebellar Neoplasms, Cerebellum, Disease Models, Animal, Genes, Retinoblastoma, Genes, Tumor Suppressor, Genes, p53, Humans, Intermediate Filament Proteins, Medulloblastoma, Mice, Nerve Tissue Proteins, Nestin, Neurons, SOX9 Transcription Factor, SOXB1 Transcription Factors, Stem Cells, Treatment Failure, Treatment Outcome, Journal Article, Research Support, Non-U.S. Gov't",

author = "Reto Sutter and O Shakhova and Harivadan Bhagat and H Behesti and Christian Sutter and S Penkar and Santuccione, {A C} and R Bernays and Heppner, {F L} and U Sch{\"u}ller and Grotzer, {M A} and H Moch and P Schraml and S Marino",

year = "2010",

month = mar,

day = "25",

doi = "10.1038/onc.2009.472",

language = "English",

volume = "29",

pages = "1845--56",

journal = "ONCOGENE",

issn = "0950-9232",

publisher = "NATURE PUBLISHING GROUP",

number = "12",

}

RIS

TY - JOUR

T1 - Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

AU - Sutter, Reto

AU - Shakhova, O

AU - Bhagat, Harivadan

AU - Behesti, H

AU - Sutter, Christian

AU - Penkar, S

AU - Santuccione, A C

AU - Bernays, R

AU - Heppner, F L

AU - Schüller, U

AU - Grotzer, M A

AU - Moch, H

AU - Schraml, P

AU - Marino, S

PY - 2010/3/25

Y1 - 2010/3/25

N2 - Cells with stem cell properties have been isolated from various areas of the postnatal mammalian brain, most recently from the postnatal mouse cerebellum. We show here that inactivation of the tumor suppressor genes Rb and p53 in these endogenous neural stem cells induced deregulated proliferation and resistance to apoptosis in vitro. Moreover, injection of these cells into mice formed medulloblastomas. Medulloblastomas are the most common malignant brain tumors of childhood, and despite recent advances in treatment they are associated with high morbidity and mortality. They are highly heterogeneous tumors characterized by a diverse genetic make-up and expression profile as well as variable prognosis. Here, we describe a novel ontogenetic pathway of medulloblastoma that significantly contributes to understanding their heterogeneity. Experimental medulloblastomas originating from neural stem cells preferentially expressed stem cell markers Nestin, Sox2 and Sox9, which were not expressed in medulloblastomas originating from granule-cell-restricted progenitors. Furthermore, the expression of these markers identified a subset of human medulloblastomas associated with a poorer clinical outcome.

AB - Cells with stem cell properties have been isolated from various areas of the postnatal mammalian brain, most recently from the postnatal mouse cerebellum. We show here that inactivation of the tumor suppressor genes Rb and p53 in these endogenous neural stem cells induced deregulated proliferation and resistance to apoptosis in vitro. Moreover, injection of these cells into mice formed medulloblastomas. Medulloblastomas are the most common malignant brain tumors of childhood, and despite recent advances in treatment they are associated with high morbidity and mortality. They are highly heterogeneous tumors characterized by a diverse genetic make-up and expression profile as well as variable prognosis. Here, we describe a novel ontogenetic pathway of medulloblastoma that significantly contributes to understanding their heterogeneity. Experimental medulloblastomas originating from neural stem cells preferentially expressed stem cell markers Nestin, Sox2 and Sox9, which were not expressed in medulloblastomas originating from granule-cell-restricted progenitors. Furthermore, the expression of these markers identified a subset of human medulloblastomas associated with a poorer clinical outcome.

KW - Animals

KW - Cerebellar Neoplasms

KW - Cerebellum

KW - Disease Models, Animal

KW - Genes, Retinoblastoma

KW - Genes, Tumor Suppressor

KW - Genes, p53

KW - Humans

KW - Intermediate Filament Proteins

KW - Medulloblastoma

KW - Mice

KW - Nerve Tissue Proteins

KW - Nestin

KW - Neurons

KW - SOX9 Transcription Factor

KW - SOXB1 Transcription Factors

KW - Stem Cells

KW - Treatment Failure

KW - Treatment Outcome

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/onc.2009.472

DO - 10.1038/onc.2009.472

M3 - SCORING: Journal article

C2 - 20062081

VL - 29

SP - 1845

EP - 1856

JO - ONCOGENE

JF - ONCOGENE

SN - 0950-9232

IS - 12

ER -