Cell cycle dependent G2 delay and killing of L929 cells after exposure to 241Am alpha particles.
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Cell cycle dependent G2 delay and killing of L929 cells after exposure to 241Am alpha particles. / Lücke-Huhle, C; Hieber, L; Beck-Bornholdt, Hans-Peter.
in: RADIAT RES, Jahrgang 100, Nr. 3, 3, 1984, S. 576-584.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cell cycle dependent G2 delay and killing of L929 cells after exposure to 241Am alpha particles.
AU - Lücke-Huhle, C
AU - Hieber, L
AU - Beck-Bornholdt, Hans-Peter
PY - 1984
Y1 - 1984
N2 - Survival and G2 delay of L929 mouse fibroblasts exposed to 3.4-MeV alpha particles depend on the cell age at the time of irradiation. Greatest sensitivity for both endpoints has been found at the G1/S transition: The surviving fraction of G1/S cells is reduced to 0.11 following 1 Gy of alpha particles compared to 0.31 for early G1 cells. The G2 + M transit time rises from 3 hr for control cells to 22 and 30 hr for cells irradiated with 0.3 Gy in G2 or at the G1/S boundary, respectively. Cells irradiated in early G1 do not show increased G2 + M transit times. Growth delay as calculated for the entire population increases linearly with dose by 23 hr/Gy of alpha particles.
AB - Survival and G2 delay of L929 mouse fibroblasts exposed to 3.4-MeV alpha particles depend on the cell age at the time of irradiation. Greatest sensitivity for both endpoints has been found at the G1/S transition: The surviving fraction of G1/S cells is reduced to 0.11 following 1 Gy of alpha particles compared to 0.31 for early G1 cells. The G2 + M transit time rises from 3 hr for control cells to 22 and 30 hr for cells irradiated with 0.3 Gy in G2 or at the G1/S boundary, respectively. Cells irradiated in early G1 do not show increased G2 + M transit times. Growth delay as calculated for the entire population increases linearly with dose by 23 hr/Gy of alpha particles.
M3 - SCORING: Zeitschriftenaufsatz
VL - 100
SP - 576
EP - 584
IS - 3
M1 - 3
ER -