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Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons

Standard

Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. / Leingärtner, A; Heisenberg, C P; Kolbeck, R; Thoenen, H; Lindholm, D.

in: J BIOL CHEM, Jahrgang 269, Nr. 2, 14.01.1994, S. 828-30.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Leingärtner, A, Heisenberg, CP, Kolbeck, R, Thoenen, H & Lindholm, D 1994, 'Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons', J BIOL CHEM, Jg. 269, Nr. 2, S. 828-30.

APA

Leingärtner, A., Heisenberg, C. P., Kolbeck, R., Thoenen, H., & Lindholm, D. (1994). Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. J BIOL CHEM, 269(2), 828-30.

Vancouver

Leingärtner A, Heisenberg CP, Kolbeck R, Thoenen H, Lindholm D. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. J BIOL CHEM. 1994 Jan 14;269(2):828-30.

Bibtex

@article{578b9c83443846bd9dfaee51ef17983b,
title = "Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons",
abstract = "Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured cerebellar granule neurons isolated from postnatal rats, whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged. The data presented are the first demonstration that one neurotrophin regulates the expression of another and provide evidence that NT-3 production in granule neurons is regulated by both BDNF and T3.",
keywords = "Animals, Brain-Derived Neurotrophic Factor, Cerebellum, Gene Expression, Nerve Growth Factors, Nerve Tissue Proteins, Neurotrophin 3, RNA, Messenger, Rats, Transcription, Genetic, Triiodothyronine",
author = "A Leing{\"a}rtner and Heisenberg, {C P} and R Kolbeck and H Thoenen and D Lindholm",
year = "1994",
month = jan,
day = "14",
language = "English",
volume = "269",
pages = "828--30",
journal = "J BIOL CHEM",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons

AU - Leingärtner, A

AU - Heisenberg, C P

AU - Kolbeck, R

AU - Thoenen, H

AU - Lindholm, D

PY - 1994/1/14

Y1 - 1994/1/14

N2 - Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured cerebellar granule neurons isolated from postnatal rats, whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged. The data presented are the first demonstration that one neurotrophin regulates the expression of another and provide evidence that NT-3 production in granule neurons is regulated by both BDNF and T3.

AB - Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured cerebellar granule neurons isolated from postnatal rats, whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged. The data presented are the first demonstration that one neurotrophin regulates the expression of another and provide evidence that NT-3 production in granule neurons is regulated by both BDNF and T3.

KW - Animals

KW - Brain-Derived Neurotrophic Factor

KW - Cerebellum

KW - Gene Expression

KW - Nerve Growth Factors

KW - Nerve Tissue Proteins

KW - Neurotrophin 3

KW - RNA, Messenger

KW - Rats

KW - Transcription, Genetic

KW - Triiodothyronine

M3 - SCORING: Journal article

C2 - 8288635

VL - 269

SP - 828

EP - 830

JO - J BIOL CHEM

JF - J BIOL CHEM

SN - 0021-9258

IS - 2

ER -