Benign course of central pontine myelinolysis in a patient with anorexia nervosa
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Benign course of central pontine myelinolysis in a patient with anorexia nervosa. / Lilje, Christian G; Heinen, Florian; Laubenberger, Jörg; Krug, Isolde; Brandis, Matthias.
in: PEDIATR NEUROL, Jahrgang 27, Nr. 2, 08.2002, S. 132-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Benign course of central pontine myelinolysis in a patient with anorexia nervosa
AU - Lilje, Christian G
AU - Heinen, Florian
AU - Laubenberger, Jörg
AU - Krug, Isolde
AU - Brandis, Matthias
PY - 2002/8
Y1 - 2002/8
N2 - Central pontine myelinolysis is a rare neurologic disorder defined by symmetric demyelination of the central base of the pons. Until recently its outcome was considered invariably poor if not fatal. We report a 15-year-old female patient with severe anorexia nervosa who acutely developed a locked-in syndrome. Magnetic resonance imaging revealed a central pontine lesion. There was no serum sodium abnormality. The corticospinal and corticonuclear tracts were intact, as assessed by serial neurophysiologic studies. Finally, the patient recovered completely both clinically and radiologically. This article discusses these observations in the light of recent reports on similar benign outcomes of central pontine myelinolysis. Although electrolyte imbalances could be overestimated and the clinical significance of the radiologic lesion is uncertain, the functional assessment of the corticospinal and corticonuclear fibers might have prognostic value.
AB - Central pontine myelinolysis is a rare neurologic disorder defined by symmetric demyelination of the central base of the pons. Until recently its outcome was considered invariably poor if not fatal. We report a 15-year-old female patient with severe anorexia nervosa who acutely developed a locked-in syndrome. Magnetic resonance imaging revealed a central pontine lesion. There was no serum sodium abnormality. The corticospinal and corticonuclear tracts were intact, as assessed by serial neurophysiologic studies. Finally, the patient recovered completely both clinically and radiologically. This article discusses these observations in the light of recent reports on similar benign outcomes of central pontine myelinolysis. Although electrolyte imbalances could be overestimated and the clinical significance of the radiologic lesion is uncertain, the functional assessment of the corticospinal and corticonuclear fibers might have prognostic value.
KW - Adolescent
KW - Anorexia Nervosa/complications
KW - Brain/pathology
KW - Evoked Potentials, Auditory, Brain Stem/physiology
KW - Evoked Potentials, Motor/physiology
KW - Evoked Potentials, Visual/physiology
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Myelinolysis, Central Pontine/etiology
KW - Severity of Illness Index
KW - Water-Electrolyte Balance
U2 - 10.1016/s0887-8994(02)00411-3
DO - 10.1016/s0887-8994(02)00411-3
M3 - SCORING: Journal article
C2 - 12213614
VL - 27
SP - 132
EP - 135
JO - PEDIATR NEUROL
JF - PEDIATR NEUROL
SN - 0887-8994
IS - 2
ER -