[Autoimmune liver diseases].
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[Autoimmune liver diseases]. / Pannicke, Nadine; Schramm, Christoph; Lohse, Ansgar W.
in: INTERNIST, Jahrgang 53, Nr. 8, 8, 2012, S. 943-946.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Autoimmune liver diseases].
AU - Pannicke, Nadine
AU - Schramm, Christoph
AU - Lohse, Ansgar W.
PY - 2012
Y1 - 2012
N2 - Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.
AB - Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.
KW - Diagnosis, Differential
KW - Humans
KW - Autoimmune Diseases/complications/diagnosis/therapy
KW - Liver Diseases/complications/diagnosis/therapy
KW - Diagnosis, Differential
KW - Humans
KW - Autoimmune Diseases/complications/diagnosis/therapy
KW - Liver Diseases/complications/diagnosis/therapy
M3 - SCORING: Zeitschriftenaufsatz
VL - 53
SP - 943
EP - 946
JO - INTERNIST
JF - INTERNIST
SN - 0020-9554
IS - 8
M1 - 8
ER -