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Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT

Standard

Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT. / Frankiewicz, Andrzej; Peczynski, Christophe; Giebel, Sebastian; Harrington, Alenca; Socié, Gerard; Niederwieser, Dietger; Scheid, Christoph; Bornhäuser, Martin; Kröger, Nicolaus; Elmaagacli, Ahmet; Afanasyev, Boris; Dreger, Peter; Rössig, Claudia; Blaise, Didier; Kratz, Christian; Yakoub-Agha, Ibrahim; Kremens, Bernhard; Niemeyer, Charlotte Marie; Wulf, Gerald; Blau, Igor; Penack, Olaf; Greinix, Hildegard; Basak, Grzegorz W.

in: FRONT IMMUNOL, Jahrgang 11, 2020, S. 1537.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Frankiewicz, A, Peczynski, C, Giebel, S, Harrington, A, Socié, G, Niederwieser, D, Scheid, C, Bornhäuser, M, Kröger, N, Elmaagacli, A, Afanasyev, B, Dreger, P, Rössig, C, Blaise, D, Kratz, C, Yakoub-Agha, I, Kremens, B, Niemeyer, CM, Wulf, G, Blau, I, Penack, O, Greinix, H & Basak, GW 2020, 'Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT', FRONT IMMUNOL, Jg. 11, S. 1537. https://doi.org/10.3389/fimmu.2020.01537

APA

Frankiewicz, A., Peczynski, C., Giebel, S., Harrington, A., Socié, G., Niederwieser, D., Scheid, C., Bornhäuser, M., Kröger, N., Elmaagacli, A., Afanasyev, B., Dreger, P., Rössig, C., Blaise, D., Kratz, C., Yakoub-Agha, I., Kremens, B., Niemeyer, C. M., Wulf, G., ... Basak, G. W. (2020). Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT. FRONT IMMUNOL, 11, 1537. https://doi.org/10.3389/fimmu.2020.01537

Vancouver

Frankiewicz A, Peczynski C, Giebel S, Harrington A, Socié G, Niederwieser D et al. Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT. FRONT IMMUNOL. 2020;11:1537. https://doi.org/10.3389/fimmu.2020.01537

Bibtex

@article{12b923fee1714b2198304e221981debc,
title = "Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT",
abstract = "Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on outcome of patients who experience severe aGvHD. Adults with hematological malignancies receiving alloHCT from either HLA-matched siblings (n = 1,328) or unrelated donors (n = 2,824) developing grade 3 or 4 aGvHD were included. In univariate analysis, the probability of TRM at 2 years was increased for countries with lower current Health Care Expenditure (HCE, p = 0.04), lower HCE as % of Gross Domestic Product per capita (p = 0.003) and lower values of the Human Development Index (p = 0.02). In a multivariate model, the risk of TRM was most strongly predicted by current HCE (HR = 0.76, p = 0.006). HCE >median was also associated with reduced risk of the overall mortality (HR 0.73, p = 0.0006) and reduced risk of treatment failure (either relapse or TRM; HR 0.77, p = 0.004). We conclude that country-specific socioeconomic factors, in particular current HCE, are strongly associated with survival of patients who experience severe aGvHD.",
author = "Andrzej Frankiewicz and Christophe Peczynski and Sebastian Giebel and Alenca Harrington and Gerard Soci{\'e} and Dietger Niederwieser and Christoph Scheid and Martin Bornh{\"a}user and Nicolaus Kr{\"o}ger and Ahmet Elmaagacli and Boris Afanasyev and Peter Dreger and Claudia R{\"o}ssig and Didier Blaise and Christian Kratz and Ibrahim Yakoub-Agha and Bernhard Kremens and Niemeyer, {Charlotte Marie} and Gerald Wulf and Igor Blau and Olaf Penack and Hildegard Greinix and Basak, {Grzegorz W}",
note = "Copyright {\textcopyright} 2020 Frankiewicz, Peczynski, Giebel, Harrington, Soci{\'e}, Niederwieser, Scheid, Bornh{\"a}user, Kr{\"o}ger, Elmaagacli, Afanasyev, Dreger, R{\"o}ssig, Blaise, Kratz, Yakoub-Agha, Kremens, Niemeyer, Wulf, Blau, Penack, Greinix and Basak.",
year = "2020",
doi = "10.3389/fimmu.2020.01537",
language = "English",
volume = "11",
pages = "1537",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT

AU - Frankiewicz, Andrzej

AU - Peczynski, Christophe

AU - Giebel, Sebastian

AU - Harrington, Alenca

AU - Socié, Gerard

AU - Niederwieser, Dietger

AU - Scheid, Christoph

AU - Bornhäuser, Martin

AU - Kröger, Nicolaus

AU - Elmaagacli, Ahmet

AU - Afanasyev, Boris

AU - Dreger, Peter

AU - Rössig, Claudia

AU - Blaise, Didier

AU - Kratz, Christian

AU - Yakoub-Agha, Ibrahim

AU - Kremens, Bernhard

AU - Niemeyer, Charlotte Marie

AU - Wulf, Gerald

AU - Blau, Igor

AU - Penack, Olaf

AU - Greinix, Hildegard

AU - Basak, Grzegorz W

N1 - Copyright © 2020 Frankiewicz, Peczynski, Giebel, Harrington, Socié, Niederwieser, Scheid, Bornhäuser, Kröger, Elmaagacli, Afanasyev, Dreger, Rössig, Blaise, Kratz, Yakoub-Agha, Kremens, Niemeyer, Wulf, Blau, Penack, Greinix and Basak.

PY - 2020

Y1 - 2020

N2 - Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on outcome of patients who experience severe aGvHD. Adults with hematological malignancies receiving alloHCT from either HLA-matched siblings (n = 1,328) or unrelated donors (n = 2,824) developing grade 3 or 4 aGvHD were included. In univariate analysis, the probability of TRM at 2 years was increased for countries with lower current Health Care Expenditure (HCE, p = 0.04), lower HCE as % of Gross Domestic Product per capita (p = 0.003) and lower values of the Human Development Index (p = 0.02). In a multivariate model, the risk of TRM was most strongly predicted by current HCE (HR = 0.76, p = 0.006). HCE >median was also associated with reduced risk of the overall mortality (HR 0.73, p = 0.0006) and reduced risk of treatment failure (either relapse or TRM; HR 0.77, p = 0.004). We conclude that country-specific socioeconomic factors, in particular current HCE, are strongly associated with survival of patients who experience severe aGvHD.

AB - Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on outcome of patients who experience severe aGvHD. Adults with hematological malignancies receiving alloHCT from either HLA-matched siblings (n = 1,328) or unrelated donors (n = 2,824) developing grade 3 or 4 aGvHD were included. In univariate analysis, the probability of TRM at 2 years was increased for countries with lower current Health Care Expenditure (HCE, p = 0.04), lower HCE as % of Gross Domestic Product per capita (p = 0.003) and lower values of the Human Development Index (p = 0.02). In a multivariate model, the risk of TRM was most strongly predicted by current HCE (HR = 0.76, p = 0.006). HCE >median was also associated with reduced risk of the overall mortality (HR 0.73, p = 0.0006) and reduced risk of treatment failure (either relapse or TRM; HR 0.77, p = 0.004). We conclude that country-specific socioeconomic factors, in particular current HCE, are strongly associated with survival of patients who experience severe aGvHD.

U2 - 10.3389/fimmu.2020.01537

DO - 10.3389/fimmu.2020.01537

M3 - SCORING: Journal article

C2 - 32793210

VL - 11

SP - 1537

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -