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Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients

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Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients. / Sugianto, Rizky Indrameikha; Ostendorf, Karen; Bauer, Elena; von der Born, Jeannine; Oh, Jun; Kemper, Markus J; Buescher, Rainer; Schmidt, Bernhard M W; Memaran, Nima; Melk, Anette.

in: PEDIATR NEPHROL, Jahrgang 38, Nr. 4, 04.2023, S. 1319-1327.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sugianto, RI, Ostendorf, K, Bauer, E, von der Born, J, Oh, J, Kemper, MJ, Buescher, R, Schmidt, BMW, Memaran, N & Melk, A 2023, 'Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients', PEDIATR NEPHROL, Jg. 38, Nr. 4, S. 1319-1327. https://doi.org/10.1007/s00467-022-05611-4

APA

Sugianto, R. I., Ostendorf, K., Bauer, E., von der Born, J., Oh, J., Kemper, M. J., Buescher, R., Schmidt, B. M. W., Memaran, N., & Melk, A. (2023). Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients. PEDIATR NEPHROL, 38(4), 1319-1327. https://doi.org/10.1007/s00467-022-05611-4

Vancouver

Sugianto RI, Ostendorf K, Bauer E, von der Born J, Oh J, Kemper MJ et al. Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients. PEDIATR NEPHROL. 2023 Apr;38(4):1319-1327. https://doi.org/10.1007/s00467-022-05611-4

Bibtex

@article{deaede351ef545a8b651b568291ca252,
title = "Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients",
abstract = "BACKGROUND: Pulse wave velocity (PWV) is a measure of arterial stiffness. We investigated PWV and blood pressure (BP) to determine to what extent BP changes contribute to arterial stiffness, and secondly, to identify influencing factors on BP in children after kidney transplantation.METHODS: Seventy children ≥ 2.5 years post-transplantation with at least two PWV measurements were included. Changes of systolic (Δ SBP) and diastolic BP (Δ DBP) were classified into {"}stable/decreasing,{"} {"}1-10 mmHg increase,{"} and {"} > 10 mmHg increase.{"} Linear mixed modeling for PWV z-score (PWVz) adjusted either for Δ SBP or Δ DBP was performed. An extended dataset with monthly entries of BP, immunosuppression, and creatinine was obtained in 35 participants over a median of 74 months to perform linear mixed modeling for SBP and DBP.RESULTS: PWVz increased with a rate of 0.11/year (95% CI 0.054 to 0.16). Compared to participants with stable BP, those with 1-10-mmHg SBP and DBP increase showed a higher PWVz of 0.59 (95% CI 0.046 to 1.13) and 0.86 (95% CI 0.43 to 1.30), respectively. A > 10-mmHg BP increase was associated with an even higher PWVz (SBP β = 0.78, 95% CI 0.22 to 1.34; DBP β = 1.37, 95% CI 0.80 to 1.94). Female sex and participants with lower eGFR showed higher PWVz. In the extended analysis, DBP was positively associated with cyclosporin A and everolimus trough levels.CONCLUSIONS: A higher increase of PWV is seen in patients with greater BP increase, with higher cyclosporin A and everolimus trough levels associated with higher BP. This emphasizes the role of BP as a modifiable risk factor for the improvement of cardiovascular outcome after transplantation. A higher resolution version of the Graphical abstract is available as Supplementary information.",
author = "Sugianto, {Rizky Indrameikha} and Karen Ostendorf and Elena Bauer and {von der Born}, Jeannine and Jun Oh and Kemper, {Markus J} and Rainer Buescher and Schmidt, {Bernhard M W} and Nima Memaran and Anette Melk",
note = "{\textcopyright} 2022. The Author(s).",
year = "2023",
month = apr,
doi = "10.1007/s00467-022-05611-4",
language = "English",
volume = "38",
pages = "1319--1327",
journal = "PEDIATR NEPHROL",
issn = "0931-041X",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients

AU - Sugianto, Rizky Indrameikha

AU - Ostendorf, Karen

AU - Bauer, Elena

AU - von der Born, Jeannine

AU - Oh, Jun

AU - Kemper, Markus J

AU - Buescher, Rainer

AU - Schmidt, Bernhard M W

AU - Memaran, Nima

AU - Melk, Anette

N1 - © 2022. The Author(s).

PY - 2023/4

Y1 - 2023/4

N2 - BACKGROUND: Pulse wave velocity (PWV) is a measure of arterial stiffness. We investigated PWV and blood pressure (BP) to determine to what extent BP changes contribute to arterial stiffness, and secondly, to identify influencing factors on BP in children after kidney transplantation.METHODS: Seventy children ≥ 2.5 years post-transplantation with at least two PWV measurements were included. Changes of systolic (Δ SBP) and diastolic BP (Δ DBP) were classified into "stable/decreasing," "1-10 mmHg increase," and " > 10 mmHg increase." Linear mixed modeling for PWV z-score (PWVz) adjusted either for Δ SBP or Δ DBP was performed. An extended dataset with monthly entries of BP, immunosuppression, and creatinine was obtained in 35 participants over a median of 74 months to perform linear mixed modeling for SBP and DBP.RESULTS: PWVz increased with a rate of 0.11/year (95% CI 0.054 to 0.16). Compared to participants with stable BP, those with 1-10-mmHg SBP and DBP increase showed a higher PWVz of 0.59 (95% CI 0.046 to 1.13) and 0.86 (95% CI 0.43 to 1.30), respectively. A > 10-mmHg BP increase was associated with an even higher PWVz (SBP β = 0.78, 95% CI 0.22 to 1.34; DBP β = 1.37, 95% CI 0.80 to 1.94). Female sex and participants with lower eGFR showed higher PWVz. In the extended analysis, DBP was positively associated with cyclosporin A and everolimus trough levels.CONCLUSIONS: A higher increase of PWV is seen in patients with greater BP increase, with higher cyclosporin A and everolimus trough levels associated with higher BP. This emphasizes the role of BP as a modifiable risk factor for the improvement of cardiovascular outcome after transplantation. A higher resolution version of the Graphical abstract is available as Supplementary information.

AB - BACKGROUND: Pulse wave velocity (PWV) is a measure of arterial stiffness. We investigated PWV and blood pressure (BP) to determine to what extent BP changes contribute to arterial stiffness, and secondly, to identify influencing factors on BP in children after kidney transplantation.METHODS: Seventy children ≥ 2.5 years post-transplantation with at least two PWV measurements were included. Changes of systolic (Δ SBP) and diastolic BP (Δ DBP) were classified into "stable/decreasing," "1-10 mmHg increase," and " > 10 mmHg increase." Linear mixed modeling for PWV z-score (PWVz) adjusted either for Δ SBP or Δ DBP was performed. An extended dataset with monthly entries of BP, immunosuppression, and creatinine was obtained in 35 participants over a median of 74 months to perform linear mixed modeling for SBP and DBP.RESULTS: PWVz increased with a rate of 0.11/year (95% CI 0.054 to 0.16). Compared to participants with stable BP, those with 1-10-mmHg SBP and DBP increase showed a higher PWVz of 0.59 (95% CI 0.046 to 1.13) and 0.86 (95% CI 0.43 to 1.30), respectively. A > 10-mmHg BP increase was associated with an even higher PWVz (SBP β = 0.78, 95% CI 0.22 to 1.34; DBP β = 1.37, 95% CI 0.80 to 1.94). Female sex and participants with lower eGFR showed higher PWVz. In the extended analysis, DBP was positively associated with cyclosporin A and everolimus trough levels.CONCLUSIONS: A higher increase of PWV is seen in patients with greater BP increase, with higher cyclosporin A and everolimus trough levels associated with higher BP. This emphasizes the role of BP as a modifiable risk factor for the improvement of cardiovascular outcome after transplantation. A higher resolution version of the Graphical abstract is available as Supplementary information.

U2 - 10.1007/s00467-022-05611-4

DO - 10.1007/s00467-022-05611-4

M3 - SCORING: Journal article

C2 - 36094669

VL - 38

SP - 1319

EP - 1327

JO - PEDIATR NEPHROL

JF - PEDIATR NEPHROL

SN - 0931-041X

IS - 4

ER -