Are cortical spreading depression and headache in migraine causally linked?
Standard
Are cortical spreading depression and headache in migraine causally linked? / Wolthausen, J; Sternberg, S; Gerloff, Christian; May, Arne.
in: CEPHALALGIA, Jahrgang 29, Nr. 2, 2, 2009, S. 244-249.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Are cortical spreading depression and headache in migraine causally linked?
AU - Wolthausen, J
AU - Sternberg, S
AU - Gerloff, Christian
AU - May, Arne
PY - 2009
Y1 - 2009
N2 - During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with aura, who suffered from headaches 6-10 days per month. Two patients were treated with flunarizine and the third patient with topiramate for the duration of 4 months. All patients reported that aura symptoms resolved completely, whereas the migraine headache attacks persisted or even increased. These observations question the theory that CSD (silent or not) is a prerequisite for migraine headaches.
AB - During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with aura, who suffered from headaches 6-10 days per month. Two patients were treated with flunarizine and the third patient with topiramate for the duration of 4 months. All patients reported that aura symptoms resolved completely, whereas the migraine headache attacks persisted or even increased. These observations question the theory that CSD (silent or not) is a prerequisite for migraine headaches.
M3 - SCORING: Zeitschriftenaufsatz
VL - 29
SP - 244
EP - 249
JO - CEPHALALGIA
JF - CEPHALALGIA
SN - 0333-1024
IS - 2
M1 - 2
ER -