Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression.

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Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression. / Roth, Carina; Pantel, Klaus; Müller, Volkmar; Rack, Brigitte; Kasimir-Bauer, Sabine; Janni, Wolfgang; Schwarzenbach, Heidi.

in: BMC CANCER, Jahrgang 11, 2011, S. 4.

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@article{894e117193f54a389ffb6c5c38988f19,
title = "Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression.",
abstract = "As cell-free circulating DNA exists predominantly as mono- and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of patients with benign and malignant breast diseases.",
keywords = "Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Disease Progression, Enzyme-Linked Immunosorbent Assay, DNA, Neoplasm/*blood, *Apoptosis, Breast Neoplasms/*blood/pathology, Caspase 3/blood/metabolism, Caspase 7/blood/metabolism, Nucleosomes/metabolism, Peptide Hydrolases/*blood/metabolism, Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Disease Progression, Enzyme-Linked Immunosorbent Assay, DNA, Neoplasm/*blood, *Apoptosis, Breast Neoplasms/*blood/pathology, Caspase 3/blood/metabolism, Caspase 7/blood/metabolism, Nucleosomes/metabolism, Peptide Hydrolases/*blood/metabolism",
author = "Carina Roth and Klaus Pantel and Volkmar M{\"u}ller and Brigitte Rack and Sabine Kasimir-Bauer and Wolfgang Janni and Heidi Schwarzenbach",
year = "2011",
doi = "10.1186/1471-2407-11-4",
language = "English",
volume = "11",
pages = "4",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression.

AU - Roth, Carina

AU - Pantel, Klaus

AU - Müller, Volkmar

AU - Rack, Brigitte

AU - Kasimir-Bauer, Sabine

AU - Janni, Wolfgang

AU - Schwarzenbach, Heidi

PY - 2011

Y1 - 2011

N2 - As cell-free circulating DNA exists predominantly as mono- and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of patients with benign and malignant breast diseases.

AB - As cell-free circulating DNA exists predominantly as mono- and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of patients with benign and malignant breast diseases.

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Young Adult

KW - Disease Progression

KW - Enzyme-Linked Immunosorbent Assay

KW - DNA, Neoplasm/blood

KW - Apoptosis

KW - Breast Neoplasms/blood/pathology

KW - Caspase 3/blood/metabolism

KW - Caspase 7/blood/metabolism

KW - Nucleosomes/metabolism

KW - Peptide Hydrolases/blood/metabolism

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Young Adult

KW - Disease Progression

KW - Enzyme-Linked Immunosorbent Assay

KW - DNA, Neoplasm/blood

KW - Apoptosis

KW - Breast Neoplasms/blood/pathology

KW - Caspase 3/blood/metabolism

KW - Caspase 7/blood/metabolism

KW - Nucleosomes/metabolism

KW - Peptide Hydrolases/blood/metabolism

U2 - 10.1186/1471-2407-11-4

DO - 10.1186/1471-2407-11-4

M3 - SCORING: Journal article

VL - 11

SP - 4

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

ER -