Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms.
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Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms. / Preuss, Ulrich W; Zetzsche, Thomas; Pogarell, Oliver; Mulert, Christoph; Frodl, Thomas; Müller, Dirk; Schmidt, Gisela; Born, Christine; Reiser, Maximilian; Möller, Hans-Jürgen; Hegerl, Ulrich; Meisenzahl, Eva M.
in: PSYCHIAT RES, Jahrgang 183, Nr. 2, 2, 2010, S. 133-139.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms.
AU - Preuss, Ulrich W
AU - Zetzsche, Thomas
AU - Pogarell, Oliver
AU - Mulert, Christoph
AU - Frodl, Thomas
AU - Müller, Dirk
AU - Schmidt, Gisela
AU - Born, Christine
AU - Reiser, Maximilian
AU - Möller, Hans-Jürgen
AU - Hegerl, Ulrich
AU - Meisenzahl, Eva M
PY - 2010
Y1 - 2010
N2 - The anterior cingulate cortex (ACC) is located at the rostum of the corpus callosum and involved in both cognitive and emotional brain processes. It has been suggested to be involved in P300 event-related potential generation. A large sample of schizophrenia inpatients and controls was examined in order to assess the potential relationship between ACC volumes and P300 characteristics in patients with more pronounced negative symptoms. In 50 male schizophrenia patients and 50 matched controls, auditory P300 and structural magnetic resonance imaging volume measurements of the ACC were obtained. Patients' negative symptoms were assessed using the PANSS (Positive and Negative Syndrome Scale). Volumetry of ACC subregions revealed a volume reduction in patients with schizophrenia compared with controls in right hemispheric rostral ACC subregions that were most pronounced in more negative schizophrenia patients. There was a positive correlation between PZ P300 amplitude and total ACC volume in the right hemisphere in schizophrenia patients with less negative symptoms. The results support the assumption that structural changes of the ACC are more pronounced in subgroups of schizophrenia patients with more negative psychopathology. In addition, while right hemisphere ACC volumes significantly differ between schizophrenia subgroups, combining measures of event-related potential (ERP) and ACC volumetry does not add additional information.
AB - The anterior cingulate cortex (ACC) is located at the rostum of the corpus callosum and involved in both cognitive and emotional brain processes. It has been suggested to be involved in P300 event-related potential generation. A large sample of schizophrenia inpatients and controls was examined in order to assess the potential relationship between ACC volumes and P300 characteristics in patients with more pronounced negative symptoms. In 50 male schizophrenia patients and 50 matched controls, auditory P300 and structural magnetic resonance imaging volume measurements of the ACC were obtained. Patients' negative symptoms were assessed using the PANSS (Positive and Negative Syndrome Scale). Volumetry of ACC subregions revealed a volume reduction in patients with schizophrenia compared with controls in right hemispheric rostral ACC subregions that were most pronounced in more negative schizophrenia patients. There was a positive correlation between PZ P300 amplitude and total ACC volume in the right hemisphere in schizophrenia patients with less negative symptoms. The results support the assumption that structural changes of the ACC are more pronounced in subgroups of schizophrenia patients with more negative psychopathology. In addition, while right hemisphere ACC volumes significantly differ between schizophrenia subgroups, combining measures of event-related potential (ERP) and ACC volumetry does not add additional information.
KW - Humans
KW - Psychiatric Status Rating Scales
KW - Schizophrenic Psychology
KW - Electroencephalography methods
KW - Statistics as Topic
KW - Magnetic Resonance Imaging methods
KW - Analysis of Variance
KW - Brain Mapping
KW - Reaction Time physiology
KW - Schizophrenia pathology
KW - Functional Laterality
KW - Acoustic Stimulation methods
KW - Event-Related Potentials, P300 physiology
KW - Gyrus Cinguli pathology
KW - Humans
KW - Psychiatric Status Rating Scales
KW - Schizophrenic Psychology
KW - Electroencephalography methods
KW - Statistics as Topic
KW - Magnetic Resonance Imaging methods
KW - Analysis of Variance
KW - Brain Mapping
KW - Reaction Time physiology
KW - Schizophrenia pathology
KW - Functional Laterality
KW - Acoustic Stimulation methods
KW - Event-Related Potentials, P300 physiology
KW - Gyrus Cinguli pathology
M3 - SCORING: Zeitschriftenaufsatz
VL - 183
SP - 133
EP - 139
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 2
M1 - 2
ER -
