Ambulant erworbene bakterielle Meningoenzephalitis: Die neue Leitlinie

TY - JOUR

T1 - Ambulant erworbene bakterielle Meningoenzephalitis: Die neue Leitlinie

AU - Hadjilaou, Alexandros

AU - Friese, Manuel Alexander

N1 - Thieme. All rights reserved.

PY - 2024/8

Y1 - 2024/8

N2 - Updating the vaccination recommendations against meningococci and pneumococci, in particular the introduction of the B vaccine as the standard vaccination for infants from January 2024 and the adaptation of the pneumococcal vaccination strategy for infants and adults aged 60 and over with the latest conjugate vaccines (PCV13, PCV15, PCV20).Emphasis on the need for rapid diagnostic lumbar puncture and simultaneous serum and cerebrospinal fluid analysis to increase diagnostic precision. The introduction of procalcitonin (PCT) in serum as an additional biomarker to differentiate between bacterial and viral meningitis.The use of multiplex PCR as a supplement, not a replacement, for standard diagnostics to speed up pathogen identification.Adaptation of antibiotic recommendations based on the current resistance situation, in particular for meningococcal meningitis, consideration of penicillin G only after resistance testing.Clarification of the areas and duration of use of dexamethasone in bacterial meningitis, particularly in pneumococcal meningitis and the controversial data situation in Listeria meningitis.New findings on the safe use of heparin in septic sinus thrombosis without increased risk of hemorrhage.

AB - Updating the vaccination recommendations against meningococci and pneumococci, in particular the introduction of the B vaccine as the standard vaccination for infants from January 2024 and the adaptation of the pneumococcal vaccination strategy for infants and adults aged 60 and over with the latest conjugate vaccines (PCV13, PCV15, PCV20).Emphasis on the need for rapid diagnostic lumbar puncture and simultaneous serum and cerebrospinal fluid analysis to increase diagnostic precision. The introduction of procalcitonin (PCT) in serum as an additional biomarker to differentiate between bacterial and viral meningitis.The use of multiplex PCR as a supplement, not a replacement, for standard diagnostics to speed up pathogen identification.Adaptation of antibiotic recommendations based on the current resistance situation, in particular for meningococcal meningitis, consideration of penicillin G only after resistance testing.Clarification of the areas and duration of use of dexamethasone in bacterial meningitis, particularly in pneumococcal meningitis and the controversial data situation in Listeria meningitis.New findings on the safe use of heparin in septic sinus thrombosis without increased risk of hemorrhage.

KW - Humans

KW - Community-Acquired Infections/diagnosis

KW - Meningoencephalitis/diagnosis

KW - Anti-Bacterial Agents/therapeutic use

KW - Infant

KW - Practice Guidelines as Topic

KW - Adult

KW - Middle Aged

KW - Meningitis, Bacterial/diagnosis

KW - Procalcitonin/blood

KW - Meningococcal Vaccines/therapeutic use

U2 - 10.1055/a-2204-5167

DO - 10.1055/a-2204-5167

M3 - SCORING: Zeitschriftenaufsatz

C2 - 39146749

VL - 149

SP - 1021

EP - 1027

JO - DEUT MED WOCHENSCHR

JF - DEUT MED WOCHENSCHR

SN - 0012-0472

IS - 17

ER -