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Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study

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Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study. / Rizza, Stefano; Luzi, Alessio; Mavilio, Maria; Ballanti, Marta; Massimi, Arianna; Porzio, Ottavia; Magrini, Andrea; Hannemann, Juliane; Menghini, Rossella; Lehrke, Michael; Staels, Bart; Grant, Peter J; Böger, Rainer H; Marx, Nikolaus; Federici, Massimo.

in: ACTA DIABETOL, Jahrgang 58, Nr. 8, 08.2021, S. 1111-1117.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rizza, S, Luzi, A, Mavilio, M, Ballanti, M, Massimi, A, Porzio, O, Magrini, A, Hannemann, J, Menghini, R, Lehrke, M, Staels, B, Grant, PJ, Böger, RH, Marx, N & Federici, M 2021, 'Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study', ACTA DIABETOL, Jg. 58, Nr. 8, S. 1111-1117. https://doi.org/10.1007/s00592-021-01676-z

APA

Rizza, S., Luzi, A., Mavilio, M., Ballanti, M., Massimi, A., Porzio, O., Magrini, A., Hannemann, J., Menghini, R., Lehrke, M., Staels, B., Grant, P. J., Böger, R. H., Marx, N., & Federici, M. (2021). Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study. ACTA DIABETOL, 58(8), 1111-1117. https://doi.org/10.1007/s00592-021-01676-z

Vancouver

Rizza S, Luzi A, Mavilio M, Ballanti M, Massimi A, Porzio O et al. Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study. ACTA DIABETOL. 2021 Aug;58(8):1111-1117. https://doi.org/10.1007/s00592-021-01676-z

Bibtex

@article{c6a2a899f523406d8c58e17cc75e57a6,
title = "Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study",
abstract = "OBJECTIVE: To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms.DESIGN AND METHODS: We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock.RESULTS: Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p < 0.001 for both), PSQI global score (p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p < 0.001).CONCLUSIONS: We demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression.",
keywords = "ARNTL Transcription Factors/blood, Adult, Blood Pressure, Circadian Rhythm/genetics, Cross-Sectional Studies, Female, Gene Expression, Glycated Hemoglobin A/analysis, Hospitals, Humans, Inflammation, Leukocyte Count, Leukocytes, Mononuclear/chemistry, Male, Middle Aged, Nuclear Receptor Subfamily 1, Group D, Member 1/blood, Nurses, RNA/blood, Shift Work Schedule, Sleep/physiology",
author = "Stefano Rizza and Alessio Luzi and Maria Mavilio and Marta Ballanti and Arianna Massimi and Ottavia Porzio and Andrea Magrini and Juliane Hannemann and Rossella Menghini and Michael Lehrke and Bart Staels and Grant, {Peter J} and B{\"o}ger, {Rainer H} and Nikolaus Marx and Massimo Federici",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
doi = "10.1007/s00592-021-01676-z",
language = "English",
volume = "58",
pages = "1111--1117",
journal = "ACTA DIABETOL",
issn = "0940-5429",
publisher = "Springer-Verlag Italia",
number = "8",

}

RIS

TY - JOUR

T1 - Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study

AU - Rizza, Stefano

AU - Luzi, Alessio

AU - Mavilio, Maria

AU - Ballanti, Marta

AU - Massimi, Arianna

AU - Porzio, Ottavia

AU - Magrini, Andrea

AU - Hannemann, Juliane

AU - Menghini, Rossella

AU - Lehrke, Michael

AU - Staels, Bart

AU - Grant, Peter J

AU - Böger, Rainer H

AU - Marx, Nikolaus

AU - Federici, Massimo

N1 - © 2021. The Author(s).

PY - 2021/8

Y1 - 2021/8

N2 - OBJECTIVE: To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms.DESIGN AND METHODS: We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock.RESULTS: Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p < 0.001 for both), PSQI global score (p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p < 0.001).CONCLUSIONS: We demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression.

AB - OBJECTIVE: To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms.DESIGN AND METHODS: We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock.RESULTS: Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p < 0.001 for both), PSQI global score (p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p < 0.001).CONCLUSIONS: We demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression.

KW - ARNTL Transcription Factors/blood

KW - Adult

KW - Blood Pressure

KW - Circadian Rhythm/genetics

KW - Cross-Sectional Studies

KW - Female

KW - Gene Expression

KW - Glycated Hemoglobin A/analysis

KW - Hospitals

KW - Humans

KW - Inflammation

KW - Leukocyte Count

KW - Leukocytes, Mononuclear/chemistry

KW - Male

KW - Middle Aged

KW - Nuclear Receptor Subfamily 1, Group D, Member 1/blood

KW - Nurses

KW - RNA/blood

KW - Shift Work Schedule

KW - Sleep/physiology

U2 - 10.1007/s00592-021-01676-z

DO - 10.1007/s00592-021-01676-z

M3 - SCORING: Journal article

C2 - 33788000

VL - 58

SP - 1111

EP - 1117

JO - ACTA DIABETOL

JF - ACTA DIABETOL

SN - 0940-5429

IS - 8

ER -