Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
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Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. / McCubrey, James A; Sokolosky, Melissa L; Lehmann, Brian D; Taylor, Jackson R; Navolanic, Patrick M; Chappell, William H; Abrams, Stephen L; Stadelman, Kristin M; Wong, Ellis W T; Misaghian, Negin; Horn, Stefan; Bäsecke, Jörg; Libra, Massimo; Stivala, Franca; Ligresti, Giovanni; Tafuri, Agostino; Milella, Michele; Zarzycki, Marek; Dzugaj, Andrzej; Chiarini, Francesca; Evangelisti, Camilla; Martelli, Alberto M; Terrian, David M; Franklin, Richard A; Steelman, Linda S.
in: Advances in enzyme regulation, Jahrgang 48, 01.01.2008, S. 113-35.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
AU - McCubrey, James A
AU - Sokolosky, Melissa L
AU - Lehmann, Brian D
AU - Taylor, Jackson R
AU - Navolanic, Patrick M
AU - Chappell, William H
AU - Abrams, Stephen L
AU - Stadelman, Kristin M
AU - Wong, Ellis W T
AU - Misaghian, Negin
AU - Horn, Stefan
AU - Bäsecke, Jörg
AU - Libra, Massimo
AU - Stivala, Franca
AU - Ligresti, Giovanni
AU - Tafuri, Agostino
AU - Milella, Michele
AU - Zarzycki, Marek
AU - Dzugaj, Andrzej
AU - Chiarini, Francesca
AU - Evangelisti, Camilla
AU - Martelli, Alberto M
AU - Terrian, David M
AU - Franklin, Richard A
AU - Steelman, Linda S
PY - 2008/1/1
Y1 - 2008/1/1
KW - Antineoplastic Agents, Hormonal
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Apoptosis
KW - Breast Neoplasms
KW - Cell Aging
KW - Cell Cycle
KW - Cell Transformation, Neoplastic
KW - Doxorubicin
KW - Drug Resistance, Neoplasm
KW - Extracellular Signal-Regulated MAP Kinases
KW - Female
KW - Humans
KW - Metabolic Networks and Pathways
KW - PTEN Phosphohydrolase
KW - Phosphatidylinositol 3-Kinases
KW - Protein Kinases
KW - Proto-Oncogene Proteins c-akt
KW - Signal Transduction
KW - TOR Serine-Threonine Kinases
KW - Tumor Cells, Cultured
KW - raf Kinases
U2 - 10.1016/j.advenzreg.2008.02.006
DO - 10.1016/j.advenzreg.2008.02.006
M3 - SCORING: Journal article
C2 - 18423407
VL - 48
SP - 113
EP - 135
ER -