Acute hepatitis as a prequel to very severe aplastic anemia
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Acute hepatitis as a prequel to very severe aplastic anemia. / Weiler-Normann, Christina; Hartl, Johannes; Weidemann, Sören; von Pein, Ute-Marie; Fiedler, Walter; Schramm, Christoph; Brinkert, Florian; Kröger, Nicolaus; Christopeit, Maximilian.
in: Z GASTROENTEROL, Jahrgang 56, Nr. 1, 01.2018, S. 51-54.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Acute hepatitis as a prequel to very severe aplastic anemia
AU - Weiler-Normann, Christina
AU - Hartl, Johannes
AU - Weidemann, Sören
AU - von Pein, Ute-Marie
AU - Fiedler, Walter
AU - Schramm, Christoph
AU - Brinkert, Florian
AU - Kröger, Nicolaus
AU - Christopeit, Maximilian
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2018/1
Y1 - 2018/1
N2 - Severe aplastic anemia is a rare and potentially life-threatening disease of the bone marrow often requiring allogeneic hematopoietic stem cell transplantation. Pathogenesis of the disease can vary and often remains enigmatic. Occasionally, severe aplastic anemia is associated with prior severe acute hepatitis. Differential diagnosis of acute non-viral hepatitis challenges the physician as pathogenesis remains unclear.We here present a case of a young patient presenting with acute hepatitis followed by severe aplastic anemia successfully treated with allogeneic hematopoietic stem cell transplantation. Due to immunosuppressive treatment with azathioprine for acute hepatitis of putative autoimmune pathogenesis and coincident infection with parvovirus B19, diagnosis of the sequential disease of acute hepatitis followed by severe aplastic anemia was complicated. We discuss the caveats and present a review of the literature.
AB - Severe aplastic anemia is a rare and potentially life-threatening disease of the bone marrow often requiring allogeneic hematopoietic stem cell transplantation. Pathogenesis of the disease can vary and often remains enigmatic. Occasionally, severe aplastic anemia is associated with prior severe acute hepatitis. Differential diagnosis of acute non-viral hepatitis challenges the physician as pathogenesis remains unclear.We here present a case of a young patient presenting with acute hepatitis followed by severe aplastic anemia successfully treated with allogeneic hematopoietic stem cell transplantation. Due to immunosuppressive treatment with azathioprine for acute hepatitis of putative autoimmune pathogenesis and coincident infection with parvovirus B19, diagnosis of the sequential disease of acute hepatitis followed by severe aplastic anemia was complicated. We discuss the caveats and present a review of the literature.
KW - Journal Article
U2 - 10.1055/s-0043-121737
DO - 10.1055/s-0043-121737
M3 - SCORING: Journal article
C2 - 29316578
VL - 56
SP - 51
EP - 54
JO - Z GASTROENTEROL
JF - Z GASTROENTEROL
SN - 0044-2771
IS - 1
ER -