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Activation of the opioidergic descending pain control system underlies placebo analgesia

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Activation of the opioidergic descending pain control system underlies placebo analgesia. / Eippert, Falk; Bingel, Ulrike; Schoell, Eszter D; Yacubian, Juliana; Klinger, Regine; Lorenz, Jürgen; Büchel, Christian.

in: NEURON, Jahrgang 63, Nr. 4, 27.08.2009, S. 533-43.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Eippert, F, Bingel, U, Schoell, ED, Yacubian, J, Klinger, R, Lorenz, J & Büchel, C 2009, 'Activation of the opioidergic descending pain control system underlies placebo analgesia', NEURON, Jg. 63, Nr. 4, S. 533-43. https://doi.org/10.1016/j.neuron.2009.07.014

APA

Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009). Activation of the opioidergic descending pain control system underlies placebo analgesia. NEURON, 63(4), 533-43. https://doi.org/10.1016/j.neuron.2009.07.014

Vancouver

Eippert F, Bingel U, Schoell ED, Yacubian J, Klinger R, Lorenz J et al. Activation of the opioidergic descending pain control system underlies placebo analgesia. NEURON. 2009 Aug 27;63(4):533-43. https://doi.org/10.1016/j.neuron.2009.07.014

Bibtex

@article{76833c6e82b74574979354598facca5d,
title = "Activation of the opioidergic descending pain control system underlies placebo analgesia",
abstract = "Placebo analgesia involves the endogenous opioid system, as administration of the opioid antagonist naloxone decreases placebo analgesia. To investigate the opioidergic mechanisms that underlie placebo analgesia, we combined naloxone administration with functional magnetic resonance imaging. Naloxone reduced both behavioral and neural placebo effects as well as placebo-induced responses in pain-modulatory cortical structures, such as the rostral anterior cingulate cortex (rACC). In a brainstem-specific analysis, we observed a similar naloxone modulation of placebo-induced responses in key structures of the descending pain control system, including the hypothalamus, the periaqueductal gray (PAG), and the rostral ventromedial medulla (RVM). Most importantly, naloxone abolished placebo-induced coupling between rACC and PAG, which predicted both neural and behavioral placebo effects as well as activation of the RVM. These findings show that opioidergic signaling in pain-modulating areas and the projections to downstream effectors of the descending pain control system are crucially important for placebo analgesia.",
keywords = "Adult, Analgesia, Analgesics, Opioid, Double-Blind Method, Humans, Male, Naloxone, Pain, Pain Measurement, Placebo Effect, Pyramidal Tracts, Receptors, Opioid, Signal Transduction, Young Adult, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "Falk Eippert and Ulrike Bingel and Schoell, {Eszter D} and Juliana Yacubian and Regine Klinger and J{\"u}rgen Lorenz and Christian B{\"u}chel",
year = "2009",
month = aug,
day = "27",
doi = "10.1016/j.neuron.2009.07.014",
language = "English",
volume = "63",
pages = "533--43",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Activation of the opioidergic descending pain control system underlies placebo analgesia

AU - Eippert, Falk

AU - Bingel, Ulrike

AU - Schoell, Eszter D

AU - Yacubian, Juliana

AU - Klinger, Regine

AU - Lorenz, Jürgen

AU - Büchel, Christian

PY - 2009/8/27

Y1 - 2009/8/27

N2 - Placebo analgesia involves the endogenous opioid system, as administration of the opioid antagonist naloxone decreases placebo analgesia. To investigate the opioidergic mechanisms that underlie placebo analgesia, we combined naloxone administration with functional magnetic resonance imaging. Naloxone reduced both behavioral and neural placebo effects as well as placebo-induced responses in pain-modulatory cortical structures, such as the rostral anterior cingulate cortex (rACC). In a brainstem-specific analysis, we observed a similar naloxone modulation of placebo-induced responses in key structures of the descending pain control system, including the hypothalamus, the periaqueductal gray (PAG), and the rostral ventromedial medulla (RVM). Most importantly, naloxone abolished placebo-induced coupling between rACC and PAG, which predicted both neural and behavioral placebo effects as well as activation of the RVM. These findings show that opioidergic signaling in pain-modulating areas and the projections to downstream effectors of the descending pain control system are crucially important for placebo analgesia.

AB - Placebo analgesia involves the endogenous opioid system, as administration of the opioid antagonist naloxone decreases placebo analgesia. To investigate the opioidergic mechanisms that underlie placebo analgesia, we combined naloxone administration with functional magnetic resonance imaging. Naloxone reduced both behavioral and neural placebo effects as well as placebo-induced responses in pain-modulatory cortical structures, such as the rostral anterior cingulate cortex (rACC). In a brainstem-specific analysis, we observed a similar naloxone modulation of placebo-induced responses in key structures of the descending pain control system, including the hypothalamus, the periaqueductal gray (PAG), and the rostral ventromedial medulla (RVM). Most importantly, naloxone abolished placebo-induced coupling between rACC and PAG, which predicted both neural and behavioral placebo effects as well as activation of the RVM. These findings show that opioidergic signaling in pain-modulating areas and the projections to downstream effectors of the descending pain control system are crucially important for placebo analgesia.

KW - Adult

KW - Analgesia

KW - Analgesics, Opioid

KW - Double-Blind Method

KW - Humans

KW - Male

KW - Naloxone

KW - Pain

KW - Pain Measurement

KW - Placebo Effect

KW - Pyramidal Tracts

KW - Receptors, Opioid

KW - Signal Transduction

KW - Young Adult

KW - Comparative Study

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.neuron.2009.07.014

DO - 10.1016/j.neuron.2009.07.014

M3 - SCORING: Journal article

C2 - 19709634

VL - 63

SP - 533

EP - 543

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 4

ER -