A phantom approach to interscanner comparability of computed tomographic brain perfusion parameters
Standard
A phantom approach to interscanner comparability of computed tomographic brain perfusion parameters. / Mathys, Christian; Rybacki, Konrad; Wittsack, Hans-Jörg; Lanzman, Rotem Shlomo; Miese, Falk Roland; Macht, Stephan; Eicker, Sven; Meyer zu Hörste, Gerd; Antoch, Gerald; Turowski, Bernd.
in: J COMPUT ASSIST TOMO, Jahrgang 36, Nr. 6, 30.11.2012, S. 732-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - A phantom approach to interscanner comparability of computed tomographic brain perfusion parameters
AU - Mathys, Christian
AU - Rybacki, Konrad
AU - Wittsack, Hans-Jörg
AU - Lanzman, Rotem Shlomo
AU - Miese, Falk Roland
AU - Macht, Stephan
AU - Eicker, Sven
AU - Meyer zu Hörste, Gerd
AU - Antoch, Gerald
AU - Turowski, Bernd
PY - 2012/11/30
Y1 - 2012/11/30
N2 - OBJECTIVE: This study aimed to create a phantom, which allows reproducible computed tomography perfusion experiments, and to identify the influence of contrast bolus configuration, scan parameters, and scanner hardware on the calculation of perfusion parameters.METHODS: A discoid perfusion phantom with centrifugally directed flow was constructed. Brain parenchyma was simulated by inert polyoxymethylene spheres. Repeated measurements were performed with variations of the above-mentioned factors, and their effects on perfusion results were analyzed.RESULTS: Calculated flow values measured during experiments were reproducible and showed good correlation with the true flow (R = 0.995, P < 0.01). Tube voltage, injection rate of the contrast agent, the mathematical perfusion algorithm, and the hardware of the scanner hardware had a reproducible influence on calculated perfusion results.CONCLUSIONS: In the long term, perfusion phantoms might be helpful in identifying hardware-specific and protocol-related factors of different computed tomography scanners to improve comparability of different scanners and scanning protocols.
AB - OBJECTIVE: This study aimed to create a phantom, which allows reproducible computed tomography perfusion experiments, and to identify the influence of contrast bolus configuration, scan parameters, and scanner hardware on the calculation of perfusion parameters.METHODS: A discoid perfusion phantom with centrifugally directed flow was constructed. Brain parenchyma was simulated by inert polyoxymethylene spheres. Repeated measurements were performed with variations of the above-mentioned factors, and their effects on perfusion results were analyzed.RESULTS: Calculated flow values measured during experiments were reproducible and showed good correlation with the true flow (R = 0.995, P < 0.01). Tube voltage, injection rate of the contrast agent, the mathematical perfusion algorithm, and the hardware of the scanner hardware had a reproducible influence on calculated perfusion results.CONCLUSIONS: In the long term, perfusion phantoms might be helpful in identifying hardware-specific and protocol-related factors of different computed tomography scanners to improve comparability of different scanners and scanning protocols.
KW - Algorithms
KW - Blood Flow Velocity
KW - Brain
KW - Cerebrovascular Circulation
KW - Contrast Media
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Phantoms, Imaging
KW - Radiographic Image Enhancement
KW - Reproducibility of Results
KW - Tomography, Spiral Computed
KW - Tomography, X-Ray Computed
U2 - 10.1097/RCT.0b013e31826801df
DO - 10.1097/RCT.0b013e31826801df
M3 - SCORING: Journal article
C2 - 23192212
VL - 36
SP - 732
EP - 738
JO - J COMPUT ASSIST TOMO
JF - J COMPUT ASSIST TOMO
SN - 0363-8715
IS - 6
ER -
