A novel titanium implant surface modification by plasma electrolytic oxidation (PEO) preventing tendon adhesion
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A novel titanium implant surface modification by plasma electrolytic oxidation (PEO) preventing tendon adhesion. / Becerikli, Mustafa; Kopp, Alexander; Kröger, Nadja; Bodrova, Mariia; Wallner, Christoph; Wagner, Johannes Maximilian; Dadras, Mehran; Jettkant, Birger; Pöhl, Fabian; Lehnhardt, Marcus; Jung, Ole; Behr, Björn.
in: MAT SCI ENG C-MATER, Jahrgang 123, 112030, 04.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A novel titanium implant surface modification by plasma electrolytic oxidation (PEO) preventing tendon adhesion
AU - Becerikli, Mustafa
AU - Kopp, Alexander
AU - Kröger, Nadja
AU - Bodrova, Mariia
AU - Wallner, Christoph
AU - Wagner, Johannes Maximilian
AU - Dadras, Mehran
AU - Jettkant, Birger
AU - Pöhl, Fabian
AU - Lehnhardt, Marcus
AU - Jung, Ole
AU - Behr, Björn
N1 - Copyright © 2021 Elsevier B.V. All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Titanium is one of the most commonly used materials for implants in trauma applications due to its low density, high corrosion resistance and biocompatibility. Nevertheless, there is still a need for improved surface modifications of Titanium, in order to change surface properties such as wettability, antibacterial properties or tissue attachment. In this study, different novel plasma electrolytic oxidation (PEO) modifications have been investigated for tendon adhesion to implants commonly used in hand surgery. Titanium samples with four different PEO modifications were prepared by varying the electrolyte composition and analyzed with regards to their surface properties. Unmodified titanium blanks and Dotize® coating served as controls. Samples were examined using scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), contact angle measuring system and analyzed for their biocompatibility and hemocompatibility (according to DIN ISO 10993-5 and 10,993-4). Finally, tendon adhesion of these specific surfaces were investigated by pull-off tests. Our findings show that surface thickness of PEO modifications was about 12-20 μm and had porous morphology. One modification demonstrated hydrophilic behavior accompanied by good biocompatibility without showing cytotoxic properties. Furthermore, no hemolytic effect and no significant influence on hemocompatibility were observed. Pull-off tests revealed a significant reduction of tendon adhesion by 64.3% (35.7% residual adhesion), compared to unmodified titanium (100%). In summary, the novel PEO-based ceramic-like porous modification for titanium surfaces might be considered a good candidate for orthopedic applications supporting a more efficient recovery.
AB - Titanium is one of the most commonly used materials for implants in trauma applications due to its low density, high corrosion resistance and biocompatibility. Nevertheless, there is still a need for improved surface modifications of Titanium, in order to change surface properties such as wettability, antibacterial properties or tissue attachment. In this study, different novel plasma electrolytic oxidation (PEO) modifications have been investigated for tendon adhesion to implants commonly used in hand surgery. Titanium samples with four different PEO modifications were prepared by varying the electrolyte composition and analyzed with regards to their surface properties. Unmodified titanium blanks and Dotize® coating served as controls. Samples were examined using scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), contact angle measuring system and analyzed for their biocompatibility and hemocompatibility (according to DIN ISO 10993-5 and 10,993-4). Finally, tendon adhesion of these specific surfaces were investigated by pull-off tests. Our findings show that surface thickness of PEO modifications was about 12-20 μm and had porous morphology. One modification demonstrated hydrophilic behavior accompanied by good biocompatibility without showing cytotoxic properties. Furthermore, no hemolytic effect and no significant influence on hemocompatibility were observed. Pull-off tests revealed a significant reduction of tendon adhesion by 64.3% (35.7% residual adhesion), compared to unmodified titanium (100%). In summary, the novel PEO-based ceramic-like porous modification for titanium surfaces might be considered a good candidate for orthopedic applications supporting a more efficient recovery.
U2 - 10.1016/j.msec.2021.112030
DO - 10.1016/j.msec.2021.112030
M3 - SCORING: Journal article
C2 - 33812645
VL - 123
JO - MAT SCI ENG C-MATER
JF - MAT SCI ENG C-MATER
SN - 0928-4931
M1 - 112030
ER -