A new inverse regression model applied to radiation biodosimetry
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A new inverse regression model applied to radiation biodosimetry. / Higueras, Manuel; Puig, Pedro; Ainsbury, Elizabeth A; Rothkamm, Kai.
in: P ROY SOC A-MATH PHY, Jahrgang 471, Nr. 2174, 08.02.2015, S. 20140588.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A new inverse regression model applied to radiation biodosimetry
AU - Higueras, Manuel
AU - Puig, Pedro
AU - Ainsbury, Elizabeth A
AU - Rothkamm, Kai
PY - 2015/2/8
Y1 - 2015/2/8
N2 - Biological dosimetry based on chromosome aberration scoring in peripheral blood lymphocytes enables timely assessment of the ionizing radiation dose absorbed by an individual. Here, new Bayesian-type count data inverse regression methods are introduced for situations where responses are Poisson or two-parameter compound Poisson distributed. Our Poisson models are calculated in a closed form, by means of Hermite and negative binomial (NB) distributions. For compound Poisson responses, complete and simplified models are provided. The simplified models are also expressible in a closed form and involve the use of compound Hermite and compound NB distributions. Three examples of applications are given that demonstrate the usefulness of these methodologies in cytogenetic radiation biodosimetry and in radiotherapy. We provide R and SAS codes which reproduce these examples.
AB - Biological dosimetry based on chromosome aberration scoring in peripheral blood lymphocytes enables timely assessment of the ionizing radiation dose absorbed by an individual. Here, new Bayesian-type count data inverse regression methods are introduced for situations where responses are Poisson or two-parameter compound Poisson distributed. Our Poisson models are calculated in a closed form, by means of Hermite and negative binomial (NB) distributions. For compound Poisson responses, complete and simplified models are provided. The simplified models are also expressible in a closed form and involve the use of compound Hermite and compound NB distributions. Three examples of applications are given that demonstrate the usefulness of these methodologies in cytogenetic radiation biodosimetry and in radiotherapy. We provide R and SAS codes which reproduce these examples.
U2 - 10.1098/rspa.2014.0588
DO - 10.1098/rspa.2014.0588
M3 - SCORING: Journal article
C2 - 25663804
VL - 471
SP - 20140588
JO - P ROY SOC A-MATH PHY
JF - P ROY SOC A-MATH PHY
SN - 1364-5021
IS - 2174
ER -