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A meta-analysis of gene expression signatures of blood pressure and hypertension

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A meta-analysis of gene expression signatures of blood pressure and hypertension. / Huan, Tianxiao; Esko, Tõnu; Peters, Marjolein J; Pilling, Luke C; Schramm, Katharina; Schurmann, Claudia; Chen, Brian H; Liu, Chunyu; Joehanes, Roby; Johnson, Andrew D; Yao, Chen; Ying, Sai-Xia; Courchesne, Paul; Milani, Lili; Raghavachari, Nalini; Wang, Richard; Liu, Poching; Reinmaa, Eva; Dehghan, Abbas; Hofman, Albert; Uitterlinden, André G; Hernandez, Dena G; Bandinelli, Stefania; Singleton, Andrew; Melzer, David; Metspalu, Andres; Carstensen, Maren; Grallert, Harald; Herder, Christian; Meitinger, Thomas; Peters, Annette; Roden, Michael; Waldenberger, Melanie; Dörr, Marcus; Felix, Stephan B; Zeller, Tanja; Vasan, Ramachandran; O'Donnell, Christopher J; Munson, Peter J; Yang, Xia; Prokisch, Holger; Völker, Uwe; van Meurs, Joyce B J; Ferrucci, Luigi; Levy, Daniel; International Consortium for Blood Pressure GWAS (ICBP).

in: PLOS GENET, Jahrgang 11, Nr. 3, 03.2015, S. e1005035.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Huan, T, Esko, T, Peters, MJ, Pilling, LC, Schramm, K, Schurmann, C, Chen, BH, Liu, C, Joehanes, R, Johnson, AD, Yao, C, Ying, S-X, Courchesne, P, Milani, L, Raghavachari, N, Wang, R, Liu, P, Reinmaa, E, Dehghan, A, Hofman, A, Uitterlinden, AG, Hernandez, DG, Bandinelli, S, Singleton, A, Melzer, D, Metspalu, A, Carstensen, M, Grallert, H, Herder, C, Meitinger, T, Peters, A, Roden, M, Waldenberger, M, Dörr, M, Felix, SB, Zeller, T, Vasan, R, O'Donnell, CJ, Munson, PJ, Yang, X, Prokisch, H, Völker, U, van Meurs, JBJ, Ferrucci, L, Levy, D & International Consortium for Blood Pressure GWAS (ICBP) 2015, 'A meta-analysis of gene expression signatures of blood pressure and hypertension', PLOS GENET, Jg. 11, Nr. 3, S. e1005035. https://doi.org/10.1371/journal.pgen.1005035

APA

Huan, T., Esko, T., Peters, M. J., Pilling, L. C., Schramm, K., Schurmann, C., Chen, B. H., Liu, C., Joehanes, R., Johnson, A. D., Yao, C., Ying, S-X., Courchesne, P., Milani, L., Raghavachari, N., Wang, R., Liu, P., Reinmaa, E., Dehghan, A., ... International Consortium for Blood Pressure GWAS (ICBP) (2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLOS GENET, 11(3), e1005035. https://doi.org/10.1371/journal.pgen.1005035

Vancouver

Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C et al. A meta-analysis of gene expression signatures of blood pressure and hypertension. PLOS GENET. 2015 Mär;11(3):e1005035. https://doi.org/10.1371/journal.pgen.1005035

Bibtex

@article{3949eafe880a44c4b700d05a10de4ba1,
title = "A meta-analysis of gene expression signatures of blood pressure and hypertension",
abstract = "Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension. ",
keywords = "Blood Pressure/genetics, Gene Expression Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Hypertension/genetics, Polymorphism, Single Nucleotide, Transcriptome/genetics",
author = "Tianxiao Huan and T{\~o}nu Esko and Peters, {Marjolein J} and Pilling, {Luke C} and Katharina Schramm and Claudia Schurmann and Chen, {Brian H} and Chunyu Liu and Roby Joehanes and Johnson, {Andrew D} and Chen Yao and Sai-Xia Ying and Paul Courchesne and Lili Milani and Nalini Raghavachari and Richard Wang and Poching Liu and Eva Reinmaa and Abbas Dehghan and Albert Hofman and Uitterlinden, {Andr{\'e} G} and Hernandez, {Dena G} and Stefania Bandinelli and Andrew Singleton and David Melzer and Andres Metspalu and Maren Carstensen and Harald Grallert and Christian Herder and Thomas Meitinger and Annette Peters and Michael Roden and Melanie Waldenberger and Marcus D{\"o}rr and Felix, {Stephan B} and Tanja Zeller and Ramachandran Vasan and O'Donnell, {Christopher J} and Munson, {Peter J} and Xia Yang and Holger Prokisch and Uwe V{\"o}lker and {van Meurs}, {Joyce B J} and Luigi Ferrucci and Daniel Levy and {International Consortium for Blood Pressure GWAS (ICBP)}",
year = "2015",
month = mar,
doi = "10.1371/journal.pgen.1005035",
language = "English",
volume = "11",
pages = "e1005035",
journal = "PLOS GENET",
issn = "1553-7404",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - A meta-analysis of gene expression signatures of blood pressure and hypertension

AU - Huan, Tianxiao

AU - Esko, Tõnu

AU - Peters, Marjolein J

AU - Pilling, Luke C

AU - Schramm, Katharina

AU - Schurmann, Claudia

AU - Chen, Brian H

AU - Liu, Chunyu

AU - Joehanes, Roby

AU - Johnson, Andrew D

AU - Yao, Chen

AU - Ying, Sai-Xia

AU - Courchesne, Paul

AU - Milani, Lili

AU - Raghavachari, Nalini

AU - Wang, Richard

AU - Liu, Poching

AU - Reinmaa, Eva

AU - Dehghan, Abbas

AU - Hofman, Albert

AU - Uitterlinden, André G

AU - Hernandez, Dena G

AU - Bandinelli, Stefania

AU - Singleton, Andrew

AU - Melzer, David

AU - Metspalu, Andres

AU - Carstensen, Maren

AU - Grallert, Harald

AU - Herder, Christian

AU - Meitinger, Thomas

AU - Peters, Annette

AU - Roden, Michael

AU - Waldenberger, Melanie

AU - Dörr, Marcus

AU - Felix, Stephan B

AU - Zeller, Tanja

AU - Vasan, Ramachandran

AU - O'Donnell, Christopher J

AU - Munson, Peter J

AU - Yang, Xia

AU - Prokisch, Holger

AU - Völker, Uwe

AU - van Meurs, Joyce B J

AU - Ferrucci, Luigi

AU - Levy, Daniel

AU - International Consortium for Blood Pressure GWAS (ICBP)

PY - 2015/3

Y1 - 2015/3

N2 - Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension.

AB - Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension.

KW - Blood Pressure/genetics

KW - Gene Expression Regulation

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Hypertension/genetics

KW - Polymorphism, Single Nucleotide

KW - Transcriptome/genetics

U2 - 10.1371/journal.pgen.1005035

DO - 10.1371/journal.pgen.1005035

M3 - SCORING: Journal article

C2 - 25785607

VL - 11

SP - e1005035

JO - PLOS GENET

JF - PLOS GENET

SN - 1553-7404

IS - 3

ER -