A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

D J Mangelsdorf; K Umesono; S A Kliewer; U Borgmeyer; E S Ong; R M Evans

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

Standard

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. / Mangelsdorf, D J; Umesono, K; Kliewer, S A; Borgmeyer, U; Ong, E S; Evans, R M.

in: CELL, Jahrgang 66, Nr. 3, 09.08.1991, S. 555-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mangelsdorf, DJ, Umesono, K, Kliewer, SA, Borgmeyer, U, Ong, ES & Evans, RM 1991, 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR', CELL, Jg. 66, Nr. 3, S. 555-61.

APA

Mangelsdorf, D. J., Umesono, K., Kliewer, S. A., Borgmeyer, U., Ong, E. S., & Evans, R. M. (1991). A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. CELL, 66(3), 555-61.

Vancouver

Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. CELL. 1991 Aug 9;66(3):555-61.

Bibtex

@article{66e358f374174d0dbd13b1a3bcc3d398,

title = "A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR",

abstract = "The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR. This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide. The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.",

keywords = "Animals, Base Sequence, Carrier Proteins, Cell Line, DNA Mutational Analysis, DNA-Binding Proteins, Gene Expression Regulation, Genes, In Vitro Techniques, Molecular Sequence Data, Oligonucleotides, Promoter Regions, Genetic, Protein Binding, RNA, Messenger, Receptors, Retinoic Acid, Regulatory Sequences, Nucleic Acid, Retinol-Binding Proteins, Retinol-Binding Proteins, Cellular, Transcription Factors, Transcription, Genetic, Tretinoin",

author = "Mangelsdorf, {D J} and K Umesono and Kliewer, {S A} and U Borgmeyer and Ong, {E S} and Evans, {R M}",

year = "1991",

month = aug,

day = "9",

language = "English",

volume = "66",

pages = "555--61",

journal = "CELL",

issn = "0092-8674",

publisher = "Cell Press",

number = "3",

}

RIS

TY - JOUR

T1 - A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

AU - Mangelsdorf, D J

AU - Umesono, K

AU - Kliewer, S A

AU - Borgmeyer, U

AU - Ong, E S

AU - Evans, R M

PY - 1991/8/9

Y1 - 1991/8/9

N2 - The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR. This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide. The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.

AB - The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR. This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide. The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.

KW - Animals

KW - Base Sequence

KW - Carrier Proteins

KW - Cell Line

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

KW - Gene Expression Regulation

KW - Genes

KW - In Vitro Techniques

KW - Molecular Sequence Data

KW - Oligonucleotides

KW - Promoter Regions, Genetic

KW - Protein Binding

KW - RNA, Messenger

KW - Receptors, Retinoic Acid

KW - Regulatory Sequences, Nucleic Acid

KW - Retinol-Binding Proteins

KW - Retinol-Binding Proteins, Cellular

KW - Transcription Factors

KW - Transcription, Genetic

KW - Tretinoin

M3 - SCORING: Journal article

C2 - 1651173

VL - 66

SP - 555

EP - 561

JO - CELL

JF - CELL

SN - 0092-8674

IS - 3

ER -