5-lipoxygenase mRNA and protein isoforms
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5-lipoxygenase mRNA and protein isoforms. / Ochs, Meike J; Suess, Beatrix; Steinhilber, Dieter.
in: BASIC CLIN PHARMACOL, Jahrgang 114, Nr. 1, 01.2014, S. 78-82.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Kurzpublikation › Forschung › Begutachtung
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TY - JOUR
T1 - 5-lipoxygenase mRNA and protein isoforms
AU - Ochs, Meike J
AU - Suess, Beatrix
AU - Steinhilber, Dieter
N1 - © 2013 Nordic Pharmacological Society. Published by John Wiley & Sons Ltd.
PY - 2014/1
Y1 - 2014/1
N2 - 5-Lipoxygenase (5-LO) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets.
AB - 5-Lipoxygenase (5-LO) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets.
KW - Arachidonate 5-Lipoxygenase/genetics
KW - B-Lymphocytes/metabolism
KW - Gene Expression Regulation, Enzymologic
KW - Humans
KW - Leukotrienes/metabolism
KW - Protein Isoforms/genetics
KW - Proteome/genetics
KW - RNA, Messenger/genetics
U2 - 10.1111/bcpt.12115
DO - 10.1111/bcpt.12115
M3 - Short publication
C2 - 24020397
VL - 114
SP - 78
EP - 82
JO - BASIC CLIN PHARMACOL
JF - BASIC CLIN PHARMACOL
SN - 1742-7835
IS - 1
ER -