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Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.

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Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. / Correa, Diego; Hesse, Eric; Seriwatanachai, Dutmanee; Kiviranta, Riku; Saito, Hiroaki; Yamana, Kei; Neff, Lynn; Atfi, Azeddine; Coillard, Lucie; Sitara, Despina; Maeda, Yukiko; Warming, Soren; Jenkins, Nancy A; Copeland, Neal G; Horne, William C; Lanske, Beate; Baron, Roland.

In: DEV CELL, Vol. 19, No. 4, 4, 2010, p. 533-546.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Correa, D, Hesse, E, Seriwatanachai, D, Kiviranta, R, Saito, H, Yamana, K, Neff, L, Atfi, A, Coillard, L, Sitara, D, Maeda, Y, Warming, S, Jenkins, NA, Copeland, NG, Horne, WC, Lanske, B & Baron, R 2010, 'Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.', DEV CELL, vol. 19, no. 4, 4, pp. 533-546. <http://www.ncbi.nlm.nih.gov/pubmed/20951345?dopt=Citation>

APA

Correa, D., Hesse, E., Seriwatanachai, D., Kiviranta, R., Saito, H., Yamana, K., Neff, L., Atfi, A., Coillard, L., Sitara, D., Maeda, Y., Warming, S., Jenkins, N. A., Copeland, N. G., Horne, W. C., Lanske, B., & Baron, R. (2010). Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. DEV CELL, 19(4), 533-546. [4]. http://www.ncbi.nlm.nih.gov/pubmed/20951345?dopt=Citation

Vancouver

Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K et al. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. DEV CELL. 2010;19(4):533-546. 4.

Bibtex

@article{ef09b30d1fb74ab4afbe52da280a5c6b,
title = "Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.",
abstract = "In the growth plate, the interplay between parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondrocyte proliferation and differentiation during longitudinal bone growth. We found that PTHrP increases the expression of Zfp521, a zinc finger transcriptional coregulator, in prehypertrophic chondrocytes. Mice with chondrocyte-targeted deletion of Zfp521 resembled PTHrP(-/-) and chondrocyte-specific PTHR1(-/-) mice, with decreased chondrocyte proliferation, early hypertrophic transition, and reduced growth plate thickness. Deleting Zfp521 increased expression of Runx2 and Runx2 target genes, and decreased Cyclin D1 and Bcl-2 expression while increasing Caspase-3 activation and apoptosis. Zfp521 associated with Runx2 in chondrocytes, antagonizing its activity via an HDAC4-dependent mechanism. PTHrP failed to upregulate Cyclin D1 and to antagonize Runx2, Ihh, and collagen X expression when Zfp521 was absent. Thus, Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation.",
keywords = "Animals, Mice, Gene Deletion, Mice, Knockout, Apoptosis/drug effects, Biological Markers/metabolism, Cell Differentiation/drug effects, Cell Proliferation/drug effects, Chondrocytes/drug effects/enzymology/*metabolism/pathology, Core Binding Factor Alpha 1 Subunit/metabolism, Gene Expression Regulation, Developmental/drug effects, Growth Plate/metabolism/*pathology, Histone Deacetylases/metabolism, Hypertrophy, Osteogenesis/drug effects, Parathyroid Hormone-Related Protein/*metabolism/pharmacology, Repressor Proteins/metabolism, *Signal Transduction/drug effects, Transcription Factors/*metabolism, Animals, Mice, Gene Deletion, Mice, Knockout, Apoptosis/drug effects, Biological Markers/metabolism, Cell Differentiation/drug effects, Cell Proliferation/drug effects, Chondrocytes/drug effects/enzymology/*metabolism/pathology, Core Binding Factor Alpha 1 Subunit/metabolism, Gene Expression Regulation, Developmental/drug effects, Growth Plate/metabolism/*pathology, Histone Deacetylases/metabolism, Hypertrophy, Osteogenesis/drug effects, Parathyroid Hormone-Related Protein/*metabolism/pharmacology, Repressor Proteins/metabolism, *Signal Transduction/drug effects, Transcription Factors/*metabolism",
author = "Diego Correa and Eric Hesse and Dutmanee Seriwatanachai and Riku Kiviranta and Hiroaki Saito and Kei Yamana and Lynn Neff and Azeddine Atfi and Lucie Coillard and Despina Sitara and Yukiko Maeda and Soren Warming and Jenkins, {Nancy A} and Copeland, {Neal G} and Horne, {William C} and Beate Lanske and Roland Baron",
year = "2010",
language = "English",
volume = "19",
pages = "533--546",
journal = "DEV CELL",
issn = "1534-5807",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.

AU - Correa, Diego

AU - Hesse, Eric

AU - Seriwatanachai, Dutmanee

AU - Kiviranta, Riku

AU - Saito, Hiroaki

AU - Yamana, Kei

AU - Neff, Lynn

AU - Atfi, Azeddine

AU - Coillard, Lucie

AU - Sitara, Despina

AU - Maeda, Yukiko

AU - Warming, Soren

AU - Jenkins, Nancy A

AU - Copeland, Neal G

AU - Horne, William C

AU - Lanske, Beate

AU - Baron, Roland

PY - 2010

Y1 - 2010

N2 - In the growth plate, the interplay between parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondrocyte proliferation and differentiation during longitudinal bone growth. We found that PTHrP increases the expression of Zfp521, a zinc finger transcriptional coregulator, in prehypertrophic chondrocytes. Mice with chondrocyte-targeted deletion of Zfp521 resembled PTHrP(-/-) and chondrocyte-specific PTHR1(-/-) mice, with decreased chondrocyte proliferation, early hypertrophic transition, and reduced growth plate thickness. Deleting Zfp521 increased expression of Runx2 and Runx2 target genes, and decreased Cyclin D1 and Bcl-2 expression while increasing Caspase-3 activation and apoptosis. Zfp521 associated with Runx2 in chondrocytes, antagonizing its activity via an HDAC4-dependent mechanism. PTHrP failed to upregulate Cyclin D1 and to antagonize Runx2, Ihh, and collagen X expression when Zfp521 was absent. Thus, Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation.

AB - In the growth plate, the interplay between parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondrocyte proliferation and differentiation during longitudinal bone growth. We found that PTHrP increases the expression of Zfp521, a zinc finger transcriptional coregulator, in prehypertrophic chondrocytes. Mice with chondrocyte-targeted deletion of Zfp521 resembled PTHrP(-/-) and chondrocyte-specific PTHR1(-/-) mice, with decreased chondrocyte proliferation, early hypertrophic transition, and reduced growth plate thickness. Deleting Zfp521 increased expression of Runx2 and Runx2 target genes, and decreased Cyclin D1 and Bcl-2 expression while increasing Caspase-3 activation and apoptosis. Zfp521 associated with Runx2 in chondrocytes, antagonizing its activity via an HDAC4-dependent mechanism. PTHrP failed to upregulate Cyclin D1 and to antagonize Runx2, Ihh, and collagen X expression when Zfp521 was absent. Thus, Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation.

KW - Animals

KW - Mice

KW - Gene Deletion

KW - Mice, Knockout

KW - Apoptosis/drug effects

KW - Biological Markers/metabolism

KW - Cell Differentiation/drug effects

KW - Cell Proliferation/drug effects

KW - Chondrocytes/drug effects/enzymology/metabolism/pathology

KW - Core Binding Factor Alpha 1 Subunit/metabolism

KW - Gene Expression Regulation, Developmental/drug effects

KW - Growth Plate/metabolism/pathology

KW - Histone Deacetylases/metabolism

KW - Hypertrophy

KW - Osteogenesis/drug effects

KW - Parathyroid Hormone-Related Protein/metabolism/pharmacology

KW - Repressor Proteins/metabolism

KW - Signal Transduction/drug effects

KW - Transcription Factors/metabolism

KW - Animals

KW - Mice

KW - Gene Deletion

KW - Mice, Knockout

KW - Apoptosis/drug effects

KW - Biological Markers/metabolism

KW - Cell Differentiation/drug effects

KW - Cell Proliferation/drug effects

KW - Chondrocytes/drug effects/enzymology/metabolism/pathology

KW - Core Binding Factor Alpha 1 Subunit/metabolism

KW - Gene Expression Regulation, Developmental/drug effects

KW - Growth Plate/metabolism/pathology

KW - Histone Deacetylases/metabolism

KW - Hypertrophy

KW - Osteogenesis/drug effects

KW - Parathyroid Hormone-Related Protein/metabolism/pharmacology

KW - Repressor Proteins/metabolism

KW - Signal Transduction/drug effects

KW - Transcription Factors/metabolism

M3 - SCORING: Journal article

VL - 19

SP - 533

EP - 546

JO - DEV CELL

JF - DEV CELL

SN - 1534-5807

IS - 4

M1 - 4

ER -