Research ExplorerPublicationsZebrafish: An Emerging Model for Orthopedic Research

Zebrafish: An Emerging Model for Orthopedic Research

Standard

Zebrafish: An Emerging Model for Orthopedic Research. / Busse, Björn; Galloway, Jenna L; Gray, Ryan S; Harris, Matthew P; Kwon, Ronald Y.

In: J ORTHOP RES, Vol. 38, No. 5, 05.2020, p. 925-936.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Busse, B, Galloway, JL, Gray, RS, Harris, MP & Kwon, RY 2020, 'Zebrafish: An Emerging Model for Orthopedic Research', J ORTHOP RES, vol. 38, no. 5, pp. 925-936. https://doi.org/10.1002/jor.24539

APA

Busse, B., Galloway, J. L., Gray, R. S., Harris, M. P., & Kwon, R. Y. (2020). Zebrafish: An Emerging Model for Orthopedic Research. J ORTHOP RES, 38(5), 925-936. https://doi.org/10.1002/jor.24539

Vancouver

Busse B, Galloway JL, Gray RS, Harris MP, Kwon RY. Zebrafish: An Emerging Model for Orthopedic Research. J ORTHOP RES. 2020 May;38(5):925-936. https://doi.org/10.1002/jor.24539

Bibtex

@article{608854da7bcb48d7a8741de78f97658e,
title = "Zebrafish: An Emerging Model for Orthopedic Research",
abstract = "Advances in next-generation sequencing have transformed our ability to identify genetic variants associated with clinical disorders of the musculoskeletal system. However, the means to functionally validate and analyze the physiological repercussions of genetic variation have lagged behind the rate of genetic discovery. The zebrafish provides an efficient model to leverage genetic analysis in an in vivo context. Its utility for orthopedic research is becoming evident in regard to both candidate gene validation as well as therapeutic discovery in tissues such as bone, tendon, muscle, and cartilage. With the development of new genetic and analytical tools to better assay aspects of skeletal tissue morphology, mineralization, composition, and biomechanics, researchers are emboldened to systematically approach how the skeleton develops and to identify the root causes, and potential treatments, of skeletal disease. {\textcopyright} 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:925-936, 2020.",
author = "Bj{\"o}rn Busse and Galloway, {Jenna L} and Gray, {Ryan S} and Harris, {Matthew P} and Kwon, {Ronald Y}",
year = "2020",
month = may,
doi = "10.1002/jor.24539",
language = "English",
volume = "38",
pages = "925--936",
journal = "J ORTHOP RES",
issn = "0736-0266",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Zebrafish: An Emerging Model for Orthopedic Research

AU - Busse, Björn

AU - Galloway, Jenna L

AU - Gray, Ryan S

AU - Harris, Matthew P

AU - Kwon, Ronald Y

PY - 2020/5

Y1 - 2020/5

N2 - Advances in next-generation sequencing have transformed our ability to identify genetic variants associated with clinical disorders of the musculoskeletal system. However, the means to functionally validate and analyze the physiological repercussions of genetic variation have lagged behind the rate of genetic discovery. The zebrafish provides an efficient model to leverage genetic analysis in an in vivo context. Its utility for orthopedic research is becoming evident in regard to both candidate gene validation as well as therapeutic discovery in tissues such as bone, tendon, muscle, and cartilage. With the development of new genetic and analytical tools to better assay aspects of skeletal tissue morphology, mineralization, composition, and biomechanics, researchers are emboldened to systematically approach how the skeleton develops and to identify the root causes, and potential treatments, of skeletal disease. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:925-936, 2020.

AB - Advances in next-generation sequencing have transformed our ability to identify genetic variants associated with clinical disorders of the musculoskeletal system. However, the means to functionally validate and analyze the physiological repercussions of genetic variation have lagged behind the rate of genetic discovery. The zebrafish provides an efficient model to leverage genetic analysis in an in vivo context. Its utility for orthopedic research is becoming evident in regard to both candidate gene validation as well as therapeutic discovery in tissues such as bone, tendon, muscle, and cartilage. With the development of new genetic and analytical tools to better assay aspects of skeletal tissue morphology, mineralization, composition, and biomechanics, researchers are emboldened to systematically approach how the skeleton develops and to identify the root causes, and potential treatments, of skeletal disease. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:925-936, 2020.

U2 - 10.1002/jor.24539

DO - 10.1002/jor.24539

M3 - SCORING: Review article

C2 - 31773769

VL - 38

SP - 925

EP - 936

JO - J ORTHOP RES

JF - J ORTHOP RES

SN - 0736-0266

IS - 5

ER -