X chromosomal recombination-a family study analysing 39 STR markers in German three-generation pedigrees.
Standard
X chromosomal recombination-a family study analysing 39 STR markers in German three-generation pedigrees. / Hering, Sandra; Edelmann, Jeanett; Augustin, Christa; Kuhlisch, Eberhard; Szibor, Reinhard.
In: INT J LEGAL MED, 2009.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - X chromosomal recombination-a family study analysing 39 STR markers in German three-generation pedigrees.
AU - Hering, Sandra
AU - Edelmann, Jeanett
AU - Augustin, Christa
AU - Kuhlisch, Eberhard
AU - Szibor, Reinhard
PY - 2009
Y1 - 2009
N2 - Typing of polymorphisms on the human chromosome X (ChrX) has become a standard technique in forensic genetics, and a growing number of short tandem repeats (STRs) has been established. Knowledge of marker recombination is of great significance especially when ChrX typing is used in forensic kinship testing. It is known that meiotic recombination is not a simple function of physical distance but crossing over events tend to be clustered. Information on genetic distances between markers can be gathered by family studies and by interpolation of gene bank data such as the Rutgers map. We typed DNA samples of pedigrees consisting of mothers with several sons and grandfather-mother-son constellations and report here the recombination characteristics of 39 ChrX STRs in up to 135 meioses.
AB - Typing of polymorphisms on the human chromosome X (ChrX) has become a standard technique in forensic genetics, and a growing number of short tandem repeats (STRs) has been established. Knowledge of marker recombination is of great significance especially when ChrX typing is used in forensic kinship testing. It is known that meiotic recombination is not a simple function of physical distance but crossing over events tend to be clustered. Information on genetic distances between markers can be gathered by family studies and by interpolation of gene bank data such as the Rutgers map. We typed DNA samples of pedigrees consisting of mothers with several sons and grandfather-mother-son constellations and report here the recombination characteristics of 39 ChrX STRs in up to 135 meioses.
M3 - SCORING: Zeitschriftenaufsatz
JO - INT J LEGAL MED
JF - INT J LEGAL MED
SN - 0937-9827
ER -
