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Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Standard

Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. / Stensjøen, Anne Line; Hommerstad, Anders; Halvorsen, Sigrun; Arheden, Håkan; Engblom, Henrik; Erlinge, David; Larsen, Alf-Inge; Sejersten Ripa, Maria; Clemmensen, Peter; Atar, Dan; Hall, Trygve S.

In: ANN NONINVAS ELECTRO, Vol. 25, No. 6, e12784, 11.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stensjøen, AL, Hommerstad, A, Halvorsen, S, Arheden, H, Engblom, H, Erlinge, D, Larsen, A-I, Sejersten Ripa, M, Clemmensen, P, Atar, D & Hall, TS 2020, 'Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention', ANN NONINVAS ELECTRO, vol. 25, no. 6, e12784. https://doi.org/10.1111/anec.12784

APA

Stensjøen, A. L., Hommerstad, A., Halvorsen, S., Arheden, H., Engblom, H., Erlinge, D., Larsen, A-I., Sejersten Ripa, M., Clemmensen, P., Atar, D., & Hall, T. S. (2020). Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. ANN NONINVAS ELECTRO, 25(6), [e12784]. https://doi.org/10.1111/anec.12784

Vancouver

Stensjøen AL, Hommerstad A, Halvorsen S, Arheden H, Engblom H, Erlinge D et al. Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. ANN NONINVAS ELECTRO. 2020 Nov;25(6). e12784. https://doi.org/10.1111/anec.12784

Bibtex

@article{903e84a017944d1f8a7f5e42fdfbf634,
title = "Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention",
abstract = "BACKGROUND: ECG changes after revascularization predicts improved outcome for patients with ST-elevation myocardial infarction (STEMI). Worst lead residual (WLR) ST deviation and resolution of worst lead ST elevation (rST elevation) are simple measures that can be obtained early after PCI. The objective of the current study was to investigate whether simple ECG measures, obtained one hour following PCI, could predict cardiac magnetic resonance (CMR)-derived myocardial salvage index (MSI), infarct size (IS), and microvascular obstruction (MVO) in patients with STEMI included in the MITOCARE trial.METHODS: The MITOCARE trial included 165 patients with a first-time STEMI presenting within six hours of symptom onset. The current analysis included patients that had an ECG recorded at baseline and one hour after PCI and underwent CMR imaging after 3-5 days. Independent core laboratories determined WLR ST deviation, rST elevation, and the CMR variables (MSI, IS, and MVO).RESULTS: 83 patients with a mean age of 61 years were included. 83.1% were males and 41% had anterior infarctions. In logistic regression models, WLR ST deviation was a statistically significant predictor of IS (OR 2.2, 95% CI 1.3-3.8) and MVO (OR 2.8, 95% CI 1.5-5.2), but not of MSI (OR 0.8, 95% CI 0.5-1.2). rST elevation showed a trend toward a significant association with IS (OR 0.3, 95% CI 0.1-1.0), but not with the other CMR variables.CONCLUSION: WLR ST deviation one hour after PCI was a predictor of IS and MVO. WLR ST deviation, a measure easily obtained from ECGs following PCI, may provide important prognostic information in patients with STEMI.",
keywords = "Electrocardiography/methods, Female, Heart/diagnostic imaging, Humans, Magnetic Resonance Imaging/methods, Male, Microvessels/pathology, Middle Aged, Myocardium/pathology, Percutaneous Coronary Intervention/methods, Predictive Value of Tests, ST Elevation Myocardial Infarction/diagnosis, Severity of Illness Index, Treatment Outcome",
author = "Stensj{\o}en, {Anne Line} and Anders Hommerstad and Sigrun Halvorsen and H{\aa}kan Arheden and Henrik Engblom and David Erlinge and Alf-Inge Larsen and {Sejersten Ripa}, Maria and Peter Clemmensen and Dan Atar and Hall, {Trygve S}",
note = "{\textcopyright} 2020 The Authors. Annals of Noninvasive Electrocardiology published by Wiley Periodicals LLC.",
year = "2020",
month = nov,
doi = "10.1111/anec.12784",
language = "English",
volume = "25",
journal = "ANN NONINVAS ELECTRO",
issn = "1082-720X",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

AU - Stensjøen, Anne Line

AU - Hommerstad, Anders

AU - Halvorsen, Sigrun

AU - Arheden, Håkan

AU - Engblom, Henrik

AU - Erlinge, David

AU - Larsen, Alf-Inge

AU - Sejersten Ripa, Maria

AU - Clemmensen, Peter

AU - Atar, Dan

AU - Hall, Trygve S

N1 - © 2020 The Authors. Annals of Noninvasive Electrocardiology published by Wiley Periodicals LLC.

PY - 2020/11

Y1 - 2020/11

N2 - BACKGROUND: ECG changes after revascularization predicts improved outcome for patients with ST-elevation myocardial infarction (STEMI). Worst lead residual (WLR) ST deviation and resolution of worst lead ST elevation (rST elevation) are simple measures that can be obtained early after PCI. The objective of the current study was to investigate whether simple ECG measures, obtained one hour following PCI, could predict cardiac magnetic resonance (CMR)-derived myocardial salvage index (MSI), infarct size (IS), and microvascular obstruction (MVO) in patients with STEMI included in the MITOCARE trial.METHODS: The MITOCARE trial included 165 patients with a first-time STEMI presenting within six hours of symptom onset. The current analysis included patients that had an ECG recorded at baseline and one hour after PCI and underwent CMR imaging after 3-5 days. Independent core laboratories determined WLR ST deviation, rST elevation, and the CMR variables (MSI, IS, and MVO).RESULTS: 83 patients with a mean age of 61 years were included. 83.1% were males and 41% had anterior infarctions. In logistic regression models, WLR ST deviation was a statistically significant predictor of IS (OR 2.2, 95% CI 1.3-3.8) and MVO (OR 2.8, 95% CI 1.5-5.2), but not of MSI (OR 0.8, 95% CI 0.5-1.2). rST elevation showed a trend toward a significant association with IS (OR 0.3, 95% CI 0.1-1.0), but not with the other CMR variables.CONCLUSION: WLR ST deviation one hour after PCI was a predictor of IS and MVO. WLR ST deviation, a measure easily obtained from ECGs following PCI, may provide important prognostic information in patients with STEMI.

AB - BACKGROUND: ECG changes after revascularization predicts improved outcome for patients with ST-elevation myocardial infarction (STEMI). Worst lead residual (WLR) ST deviation and resolution of worst lead ST elevation (rST elevation) are simple measures that can be obtained early after PCI. The objective of the current study was to investigate whether simple ECG measures, obtained one hour following PCI, could predict cardiac magnetic resonance (CMR)-derived myocardial salvage index (MSI), infarct size (IS), and microvascular obstruction (MVO) in patients with STEMI included in the MITOCARE trial.METHODS: The MITOCARE trial included 165 patients with a first-time STEMI presenting within six hours of symptom onset. The current analysis included patients that had an ECG recorded at baseline and one hour after PCI and underwent CMR imaging after 3-5 days. Independent core laboratories determined WLR ST deviation, rST elevation, and the CMR variables (MSI, IS, and MVO).RESULTS: 83 patients with a mean age of 61 years were included. 83.1% were males and 41% had anterior infarctions. In logistic regression models, WLR ST deviation was a statistically significant predictor of IS (OR 2.2, 95% CI 1.3-3.8) and MVO (OR 2.8, 95% CI 1.5-5.2), but not of MSI (OR 0.8, 95% CI 0.5-1.2). rST elevation showed a trend toward a significant association with IS (OR 0.3, 95% CI 0.1-1.0), but not with the other CMR variables.CONCLUSION: WLR ST deviation one hour after PCI was a predictor of IS and MVO. WLR ST deviation, a measure easily obtained from ECGs following PCI, may provide important prognostic information in patients with STEMI.

KW - Electrocardiography/methods

KW - Female

KW - Heart/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Microvessels/pathology

KW - Middle Aged

KW - Myocardium/pathology

KW - Percutaneous Coronary Intervention/methods

KW - Predictive Value of Tests

KW - ST Elevation Myocardial Infarction/diagnosis

KW - Severity of Illness Index

KW - Treatment Outcome

U2 - 10.1111/anec.12784

DO - 10.1111/anec.12784

M3 - SCORING: Journal article

C2 - 32592427

VL - 25

JO - ANN NONINVAS ELECTRO

JF - ANN NONINVAS ELECTRO

SN - 1082-720X

IS - 6

M1 - e12784

ER -