Worldwide Survey of COVID-19-Associated Arrhythmias
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Worldwide Survey of COVID-19-Associated Arrhythmias. / Coromilas, Ellie J; Kochav, Stephanie; Goldenthal, Isaac; Biviano, Angelo; Garan, Hasan; Goldbarg, Seth; Kim, Joon-Hyuk; Yeo, Ilhwan; Tracy, Cynthia; Ayanian, Shant; Akar, Joseph; Singh, Avinainder; Jain, Shashank; Zimerman, Leandro; Pimentel, Maurício; Osswald, Stefan; Twerenbold, Raphael; Schaerli, Nicolas; Crotti, Lia; Fabbri, Daniele; Parati, Gianfranco; Li, Yi; Atienza, Felipe; Zatarain, Eduardo; Tse, Gary; Leung, Keith Sai Kit; Guevara-Valdivia, Milton E; Rivera-Santiago, Carlos A; Soejima, Kyoko; De Filippo, Paolo; Ferrari, Paola; Malanchini, Giovanni; Kanagaratnam, Prapa; Khawaja, Saud; Mikhail, Ghada W; Scanavacca, Mauricio; Abrahão Hajjar, Ludhmila; Rizerio, Brenno; Sacilotto, Luciana; Mollazadeh, Reza; Eslami, Masoud; Laleh Far, Vahideh; Mattioli, Anna Vittoria; Boriani, Giuseppe; Migliore, Federico; Cipriani, Alberto; Donato, Filippo; Compagnucci, Paolo; Casella, Michela; Dello Russo, Antonio; Coromilas, James; Aboyme, Andrew; O'Brien, Connor Galen; Rodriguez, Fatima; Wang, Paul J; Naniwadekar, Aditi; Moey, Melissa; Kow, Chia Siang; Cheah, Wee Kooi; Auricchio, Angelo; Conte, Giulio; Hwang, Jongmin; Han, Seongwook; Lazzerini, Pietro Enea; Franchi, Federico; Santoro, Amato; Capecchi, Pier Leopoldo; Joglar, Jose A; Rosenblatt, Anna G; Zardini, Marco; Bricoli, Serena; Bonura, Rosario; Echarte-Morales, Julio; Benito-González, Tomás; Minguito-Carazo, Carlos; Fernández-Vázquez, Felipe; Wan, Elaine Y.
In: CIRC-ARRHYTHMIA ELEC, Vol. 14, No. 3, e009458, 03.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Worldwide Survey of COVID-19-Associated Arrhythmias
AU - Coromilas, Ellie J
AU - Kochav, Stephanie
AU - Goldenthal, Isaac
AU - Biviano, Angelo
AU - Garan, Hasan
AU - Goldbarg, Seth
AU - Kim, Joon-Hyuk
AU - Yeo, Ilhwan
AU - Tracy, Cynthia
AU - Ayanian, Shant
AU - Akar, Joseph
AU - Singh, Avinainder
AU - Jain, Shashank
AU - Zimerman, Leandro
AU - Pimentel, Maurício
AU - Osswald, Stefan
AU - Twerenbold, Raphael
AU - Schaerli, Nicolas
AU - Crotti, Lia
AU - Fabbri, Daniele
AU - Parati, Gianfranco
AU - Li, Yi
AU - Atienza, Felipe
AU - Zatarain, Eduardo
AU - Tse, Gary
AU - Leung, Keith Sai Kit
AU - Guevara-Valdivia, Milton E
AU - Rivera-Santiago, Carlos A
AU - Soejima, Kyoko
AU - De Filippo, Paolo
AU - Ferrari, Paola
AU - Malanchini, Giovanni
AU - Kanagaratnam, Prapa
AU - Khawaja, Saud
AU - Mikhail, Ghada W
AU - Scanavacca, Mauricio
AU - Abrahão Hajjar, Ludhmila
AU - Rizerio, Brenno
AU - Sacilotto, Luciana
AU - Mollazadeh, Reza
AU - Eslami, Masoud
AU - Laleh Far, Vahideh
AU - Mattioli, Anna Vittoria
AU - Boriani, Giuseppe
AU - Migliore, Federico
AU - Cipriani, Alberto
AU - Donato, Filippo
AU - Compagnucci, Paolo
AU - Casella, Michela
AU - Dello Russo, Antonio
AU - Coromilas, James
AU - Aboyme, Andrew
AU - O'Brien, Connor Galen
AU - Rodriguez, Fatima
AU - Wang, Paul J
AU - Naniwadekar, Aditi
AU - Moey, Melissa
AU - Kow, Chia Siang
AU - Cheah, Wee Kooi
AU - Auricchio, Angelo
AU - Conte, Giulio
AU - Hwang, Jongmin
AU - Han, Seongwook
AU - Lazzerini, Pietro Enea
AU - Franchi, Federico
AU - Santoro, Amato
AU - Capecchi, Pier Leopoldo
AU - Joglar, Jose A
AU - Rosenblatt, Anna G
AU - Zardini, Marco
AU - Bricoli, Serena
AU - Bonura, Rosario
AU - Echarte-Morales, Julio
AU - Benito-González, Tomás
AU - Minguito-Carazo, Carlos
AU - Fernández-Vázquez, Felipe
AU - Wan, Elaine Y
PY - 2021/3
Y1 - 2021/3
N2 - Background:Coronavirus disease 2019 (COVID-19) has led to over 1 million deaths worldwide and has been associated with cardiac complications including cardiac arrhythmias. The incidence and pathophysiology of these manifestations remain elusive. In this worldwide survey of patients hospitalized with COVID-19 who developed cardiac arrhythmias, we describe clinical characteristics associated with various arrhythmias, as well as global differences in modulations of routine electrophysiology practice during the pandemic.Methods:We conducted a retrospective analysis of patients hospitalized with COVID-19 infection worldwide with and without incident cardiac arrhythmias. Patients with documented atrial fibrillation, atrial flutter, supraventricular tachycardia, nonsustained or sustained ventricular tachycardia, ventricular fibrillation, atrioventricular block, or marked sinus bradycardia (heart rate<40 bpm) were classified as having arrhythmia. Deidentified data was provided by each institution and analyzed.Results:Data were collected for 4526 patients across 4 continents and 12 countries, 827 of whom had an arrhythmia. Cardiac comorbidities were common in patients with arrhythmia: 69% had hypertension, 42% diabetes, 30% had heart failure, and 24% had coronary artery disease. Most had no prior history of arrhythmia. Of those who did develop an arrhythmia, the majority (81.8%) developed atrial arrhythmias, 20.7% developed ventricular arrhythmias, and 22.6% had bradyarrhythmia. Regional differences suggested a lower incidence of atrial fibrillation in Asia compared with other continents (34% versus 63%). Most patients in North America and Europe received hydroxychloroquine, although the frequency of hydroxychloroquine therapy was constant across arrhythmia types. Forty-three percent of patients who developed arrhythmia were mechanically ventilated and 51% survived to hospital discharge. Many institutions reported drastic decreases in electrophysiology procedures performed.Conclusions:Cardiac arrhythmias are common and associated with high morbidity and mortality among patients hospitalized with COVID-19 infection. There were significant regional variations in the types of arrhythmias and treatment approaches.
AB - Background:Coronavirus disease 2019 (COVID-19) has led to over 1 million deaths worldwide and has been associated with cardiac complications including cardiac arrhythmias. The incidence and pathophysiology of these manifestations remain elusive. In this worldwide survey of patients hospitalized with COVID-19 who developed cardiac arrhythmias, we describe clinical characteristics associated with various arrhythmias, as well as global differences in modulations of routine electrophysiology practice during the pandemic.Methods:We conducted a retrospective analysis of patients hospitalized with COVID-19 infection worldwide with and without incident cardiac arrhythmias. Patients with documented atrial fibrillation, atrial flutter, supraventricular tachycardia, nonsustained or sustained ventricular tachycardia, ventricular fibrillation, atrioventricular block, or marked sinus bradycardia (heart rate<40 bpm) were classified as having arrhythmia. Deidentified data was provided by each institution and analyzed.Results:Data were collected for 4526 patients across 4 continents and 12 countries, 827 of whom had an arrhythmia. Cardiac comorbidities were common in patients with arrhythmia: 69% had hypertension, 42% diabetes, 30% had heart failure, and 24% had coronary artery disease. Most had no prior history of arrhythmia. Of those who did develop an arrhythmia, the majority (81.8%) developed atrial arrhythmias, 20.7% developed ventricular arrhythmias, and 22.6% had bradyarrhythmia. Regional differences suggested a lower incidence of atrial fibrillation in Asia compared with other continents (34% versus 63%). Most patients in North America and Europe received hydroxychloroquine, although the frequency of hydroxychloroquine therapy was constant across arrhythmia types. Forty-three percent of patients who developed arrhythmia were mechanically ventilated and 51% survived to hospital discharge. Many institutions reported drastic decreases in electrophysiology procedures performed.Conclusions:Cardiac arrhythmias are common and associated with high morbidity and mortality among patients hospitalized with COVID-19 infection. There were significant regional variations in the types of arrhythmias and treatment approaches.
KW - Aged
KW - Arrhythmias, Cardiac/epidemiology
KW - COVID-19/epidemiology
KW - Cardiac Electrophysiology/trends
KW - Comorbidity
KW - Electrophysiologic Techniques, Cardiac/trends
KW - Female
KW - Global Health/trends
KW - Health Care Surveys
KW - Healthcare Disparities
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Practice Patterns, Physicians'/trends
KW - Prevalence
KW - Prognosis
KW - Retrospective Studies
KW - Risk Assessment
KW - Time Factors
U2 - 10.1161/CIRCEP.120.009458
DO - 10.1161/CIRCEP.120.009458
M3 - SCORING: Journal article
C2 - 33554620
VL - 14
JO - CIRC-ARRHYTHMIA ELEC
JF - CIRC-ARRHYTHMIA ELEC
SN - 1941-3149
IS - 3
M1 - e009458
ER -