Women with borderline personality disorder do not show altered BOLD responses during response inhibition

TY - JOUR

T1 - Women with borderline personality disorder do not show altered BOLD responses during response inhibition

AU - van Eijk, Julia

AU - Sebastian, Alexandra

AU - Krause-Utz, Annegret

AU - Cackowski, Sylvia

AU - Demirakca, Traute

AU - Biedermann, Sarah V

AU - Lieb, Klaus

AU - Bohus, Martin

AU - Schmahl, Christian

AU - Ende, Gabriele

AU - Tüscher, Oliver

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/12/30

Y1 - 2015/12/30

N2 - Impulsivity is central to borderline personality disorder (BPD). Response inhibition, addressing the ability to suppress or stop actions, is one aspect of behavioral impulse control which is frequently used to assess impulsivity. BPD patients display deficits in response inhibition under stress condition or negative emotions. We assessed whether response inhibition and its neural underpinnings are impaired in BPD when tested in an emotionally neutral setting and when co-morbid attention-deficit/hyperactivity disorder (ADHD) is excluded. To this end, we studied response inhibition in unmedicated BPD patients and healthy controls (HC) in two independent samples using functional magnetic resonance imaging during Simon-, Go/nogo-, and Stopsignal tasks. BPD patients and HC did not differ significantly in their performance in the Go/nogo and the Stopsignal tasks. Response interference in the Simon task was increased in BPD patients in one sample, but this could not be replicated in the second sample. In both samples, no significant differences in brain activation patterns during any of the tasks were present while the neural impulse control network was robustly activated during the inhibition tasks in both groups. Our results provide evidence that under emotionally neutral conditions response inhibition is not impaired in patients with BPD without co-occurring ADHD.

AB - Impulsivity is central to borderline personality disorder (BPD). Response inhibition, addressing the ability to suppress or stop actions, is one aspect of behavioral impulse control which is frequently used to assess impulsivity. BPD patients display deficits in response inhibition under stress condition or negative emotions. We assessed whether response inhibition and its neural underpinnings are impaired in BPD when tested in an emotionally neutral setting and when co-morbid attention-deficit/hyperactivity disorder (ADHD) is excluded. To this end, we studied response inhibition in unmedicated BPD patients and healthy controls (HC) in two independent samples using functional magnetic resonance imaging during Simon-, Go/nogo-, and Stopsignal tasks. BPD patients and HC did not differ significantly in their performance in the Go/nogo and the Stopsignal tasks. Response interference in the Simon task was increased in BPD patients in one sample, but this could not be replicated in the second sample. In both samples, no significant differences in brain activation patterns during any of the tasks were present while the neural impulse control network was robustly activated during the inhibition tasks in both groups. Our results provide evidence that under emotionally neutral conditions response inhibition is not impaired in patients with BPD without co-occurring ADHD.

KW - Adult

KW - Attention Deficit Disorder with Hyperactivity

KW - Borderline Personality Disorder

KW - Disruptive, Impulse Control, and Conduct Disorders

KW - Emotions

KW - Female

KW - Humans

KW - Impulsive Behavior

KW - Inhibition (Psychology)

KW - Intelligence Tests

KW - Magnetic Resonance Imaging

KW - Middle Aged

KW - Neuropsychological Tests

KW - Psychomotor Performance

KW - Reaction Time

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.pscychresns.2015.09.017

DO - 10.1016/j.pscychresns.2015.09.017

M3 - SCORING: Journal article

C2 - 26483213

VL - 234

SP - 378

EP - 389

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

IS - 3

ER -