Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed.
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Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed. / Dikomey, Ekkehard; Borgmann, Kerstin; Peacock, John; Jung, Horst.
In: INT J RADIAT ONCOL, Vol. 56, No. 4, 4, 2003, p. 1194-1200.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed.
AU - Dikomey, Ekkehard
AU - Borgmann, Kerstin
AU - Peacock, John
AU - Jung, Horst
PY - 2003
Y1 - 2003
N2 - PURPOSE: New insights into the kinetics of late complications occurring after radiation therapy indicated that all patients have a constant risk of developing late tissue complications. These observations might have a great impact on studies relating normal tissue complications to individual radiosensitivity. METHODS AND MATERIALS: Data previously published by Peacock et al. were used for analysis. In this study, 39 breast cancer patients with severe reactions (responders) were compared with 65 matched patients showing no reactions (nonresponders). Cellular radiosensitivity as measured in vitro in terms of D(0.01) did not show significant differences between the two groups, both for high-dose-rate (5.84 +/- 0.06 vs. 5.85 +/- 0.07 Gy) and low-dose-rate (7.44 +/- 0.10 vs. 7.56 +/- 0.09 Gy) irradiation. RESULTS: A theoretical distribution was calculated for the individual radiosensitivity of patients with Grade or=(MV + SD), a normal group with a sensitivity between MV - SD and MV + SD, and a sensitive group
AB - PURPOSE: New insights into the kinetics of late complications occurring after radiation therapy indicated that all patients have a constant risk of developing late tissue complications. These observations might have a great impact on studies relating normal tissue complications to individual radiosensitivity. METHODS AND MATERIALS: Data previously published by Peacock et al. were used for analysis. In this study, 39 breast cancer patients with severe reactions (responders) were compared with 65 matched patients showing no reactions (nonresponders). Cellular radiosensitivity as measured in vitro in terms of D(0.01) did not show significant differences between the two groups, both for high-dose-rate (5.84 +/- 0.06 vs. 5.85 +/- 0.07 Gy) and low-dose-rate (7.44 +/- 0.10 vs. 7.56 +/- 0.09 Gy) irradiation. RESULTS: A theoretical distribution was calculated for the individual radiosensitivity of patients with Grade or=(MV + SD), a normal group with a sensitivity between MV - SD and MV + SD, and a sensitive group
M3 - SCORING: Zeitschriftenaufsatz
VL - 56
SP - 1194
EP - 1200
JO - INT J RADIAT ONCOL
JF - INT J RADIAT ONCOL
SN - 0360-3016
IS - 4
M1 - 4
ER -
