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White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents

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White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents. / Albaugh, Matthew D; Hudziak, James J; Ing, Alex; Chaarani, Bader; Barker, Edward; Jia, Tianye; Lemaitre, Herve; Watts, Richard; Orr, Catherine; Spechler, Philip A; Lepage, Claude; Fonov, Vladimir; Collins, Louis; Rioux, Pierre; Evans, Alan C; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Garavan, Hugh; Potter, Alexandra.

In: NEUROPSYCHOPHARMACOL, Vol. 44, No. 9, 08.2019, p. 1597-1603.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Albaugh, MD, Hudziak, JJ, Ing, A, Chaarani, B, Barker, E, Jia, T, Lemaitre, H, Watts, R, Orr, C, Spechler, PA, Lepage, C, Fonov, V, Collins, L, Rioux, P, Evans, AC, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Frouin, V, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Garavan, H & Potter, A 2019, 'White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents', NEUROPSYCHOPHARMACOL, vol. 44, no. 9, pp. 1597-1603. https://doi.org/10.1038/s41386-019-0383-y

APA

Albaugh, M. D., Hudziak, J. J., Ing, A., Chaarani, B., Barker, E., Jia, T., Lemaitre, H., Watts, R., Orr, C., Spechler, P. A., Lepage, C., Fonov, V., Collins, L., Rioux, P., Evans, A. C., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., ... Potter, A. (2019). White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents. NEUROPSYCHOPHARMACOL, 44(9), 1597-1603. https://doi.org/10.1038/s41386-019-0383-y

Vancouver

Albaugh MD, Hudziak JJ, Ing A, Chaarani B, Barker E, Jia T et al. White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents. NEUROPSYCHOPHARMACOL. 2019 Aug;44(9):1597-1603. https://doi.org/10.1038/s41386-019-0383-y

Bibtex

@article{8771eaaad7e14aafa179891fc2900f42,
title = "White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents",
abstract = "Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to which ADHD symptomatology is associated with white matter microstructure and cerebral cortical thickness in a large population-based sample of adolescents. Critically, we then test the extent to which multimodal correlates of ADHD symptomatology are related to ADHD polygenic risk score (PRS). Neuroimaging, genetic, and behavioral data were obtained from the IMAGEN study. A dimensional ADHD composite score was derived from multi-informant ratings of ADHD symptomatology. Using tract-based spatial statistics, whole brain voxel-wise regressions between fractional anisotropy (FA) and ADHD composite score were calculated. Local cortical thickness was regressed on ADHD composite score. ADHD PRS was based on a very recent genome-wide association study, and calculated using PRSice. ADHD composite score was negatively associated with FA in several white matter pathways, including bilateral superior and inferior longitudinal fasciculi (p < 0.05, corrected). ADHD composite score was negatively associated with orbitofrontal cortical thickness (p < 0.05, corrected). The ADHD composite score was correlated with ADHD PRS (p < 0.001). FA correlates of ADHD symptomatology were significantly associated with ADHD PRS, whereas cortical thickness correlates of ADHD symptomatology were unrelated to ADHD PRS. Variation in hyperactive/inattentive symptomatology was associated with white matter microstructure, which, in turn, was related to ADHD PRS. Results suggest that genetic risk for ADHD symptomatology may be tied to biological processes affecting white matter microstructure.",
author = "Albaugh, {Matthew D} and Hudziak, {James J} and Alex Ing and Bader Chaarani and Edward Barker and Tianye Jia and Herve Lemaitre and Richard Watts and Catherine Orr and Spechler, {Philip A} and Claude Lepage and Vladimir Fonov and Louis Collins and Pierre Rioux and Evans, {Alan C} and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Hugh Garavan and Alexandra Potter",
year = "2019",
month = aug,
doi = "10.1038/s41386-019-0383-y",
language = "English",
volume = "44",
pages = "1597--1603",
journal = "NEUROPSYCHOPHARMACOL",
issn = "0893-133X",
publisher = "NATURE PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents

AU - Albaugh, Matthew D

AU - Hudziak, James J

AU - Ing, Alex

AU - Chaarani, Bader

AU - Barker, Edward

AU - Jia, Tianye

AU - Lemaitre, Herve

AU - Watts, Richard

AU - Orr, Catherine

AU - Spechler, Philip A

AU - Lepage, Claude

AU - Fonov, Vladimir

AU - Collins, Louis

AU - Rioux, Pierre

AU - Evans, Alan C

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - Potter, Alexandra

PY - 2019/8

Y1 - 2019/8

N2 - Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to which ADHD symptomatology is associated with white matter microstructure and cerebral cortical thickness in a large population-based sample of adolescents. Critically, we then test the extent to which multimodal correlates of ADHD symptomatology are related to ADHD polygenic risk score (PRS). Neuroimaging, genetic, and behavioral data were obtained from the IMAGEN study. A dimensional ADHD composite score was derived from multi-informant ratings of ADHD symptomatology. Using tract-based spatial statistics, whole brain voxel-wise regressions between fractional anisotropy (FA) and ADHD composite score were calculated. Local cortical thickness was regressed on ADHD composite score. ADHD PRS was based on a very recent genome-wide association study, and calculated using PRSice. ADHD composite score was negatively associated with FA in several white matter pathways, including bilateral superior and inferior longitudinal fasciculi (p < 0.05, corrected). ADHD composite score was negatively associated with orbitofrontal cortical thickness (p < 0.05, corrected). The ADHD composite score was correlated with ADHD PRS (p < 0.001). FA correlates of ADHD symptomatology were significantly associated with ADHD PRS, whereas cortical thickness correlates of ADHD symptomatology were unrelated to ADHD PRS. Variation in hyperactive/inattentive symptomatology was associated with white matter microstructure, which, in turn, was related to ADHD PRS. Results suggest that genetic risk for ADHD symptomatology may be tied to biological processes affecting white matter microstructure.

AB - Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to which ADHD symptomatology is associated with white matter microstructure and cerebral cortical thickness in a large population-based sample of adolescents. Critically, we then test the extent to which multimodal correlates of ADHD symptomatology are related to ADHD polygenic risk score (PRS). Neuroimaging, genetic, and behavioral data were obtained from the IMAGEN study. A dimensional ADHD composite score was derived from multi-informant ratings of ADHD symptomatology. Using tract-based spatial statistics, whole brain voxel-wise regressions between fractional anisotropy (FA) and ADHD composite score were calculated. Local cortical thickness was regressed on ADHD composite score. ADHD PRS was based on a very recent genome-wide association study, and calculated using PRSice. ADHD composite score was negatively associated with FA in several white matter pathways, including bilateral superior and inferior longitudinal fasciculi (p < 0.05, corrected). ADHD composite score was negatively associated with orbitofrontal cortical thickness (p < 0.05, corrected). The ADHD composite score was correlated with ADHD PRS (p < 0.001). FA correlates of ADHD symptomatology were significantly associated with ADHD PRS, whereas cortical thickness correlates of ADHD symptomatology were unrelated to ADHD PRS. Variation in hyperactive/inattentive symptomatology was associated with white matter microstructure, which, in turn, was related to ADHD PRS. Results suggest that genetic risk for ADHD symptomatology may be tied to biological processes affecting white matter microstructure.

U2 - 10.1038/s41386-019-0383-y

DO - 10.1038/s41386-019-0383-y

M3 - SCORING: Journal article

C2 - 30952157

VL - 44

SP - 1597

EP - 1603

JO - NEUROPSYCHOPHARMACOL

JF - NEUROPSYCHOPHARMACOL

SN - 0893-133X

IS - 9

ER -