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Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?

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Which PASI Outcome Is Most Relevant to the Patients in Real-World Care? / Kirsten, Natalia; Rustenbach, Stephan; von Kiedrowski, Ralph; Sorbe, Christina; Reich, Kristian; Augustin, Matthias.

In: LIFE-BASEL, Vol. 11, No. 11, 1151, 28.10.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kirsten, N, Rustenbach, S, von Kiedrowski, R, Sorbe, C, Reich, K & Augustin, M 2021, 'Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?', LIFE-BASEL, vol. 11, no. 11, 1151. https://doi.org/10.3390/life11111151

APA

Kirsten, N., Rustenbach, S., von Kiedrowski, R., Sorbe, C., Reich, K., & Augustin, M. (2021). Which PASI Outcome Is Most Relevant to the Patients in Real-World Care? LIFE-BASEL, 11(11), [1151]. https://doi.org/10.3390/life11111151

Vancouver

Kirsten N, Rustenbach S, von Kiedrowski R, Sorbe C, Reich K, Augustin M. Which PASI Outcome Is Most Relevant to the Patients in Real-World Care? LIFE-BASEL. 2021 Oct 28;11(11). 1151. https://doi.org/10.3390/life11111151

Bibtex

@article{101492c69dad41608b63a782c38d299b,
title = "Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?",
abstract = "In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters PASI, DLQI, and PBI were intercorrelated and related to two anchoring variables: (1) patient satisfaction with treatment and (2) perceived complete clearance. Baseline data were as follows: PASI 10.5 ± 9.1, DLQI 12.4 ± 3.4, and PBI 2.7 ± 0.3. There was an almost linear relationship between {"}complete patient satisfaction{"} and the relative differences in PASI in the range from PASI 25 to PASI 90. However, there was no additional benefit between PASI 90 and PASI 100. The same finding resulted from the anchoring variable {"}perception of complete healing{"}. When related to DLQI outcomes, relative PASI changes as well as absolute changes and PASI at 3 and 6 months showed relevant differences between the PASI classes 25 to 90 but not between PASI 90 and PASI 100. Under real-world conditions, changes in PASI and DLQI reflect patient-relevant benefits.",
author = "Natalia Kirsten and Stephan Rustenbach and {von Kiedrowski}, Ralph and Christina Sorbe and Kristian Reich and Matthias Augustin",
year = "2021",
month = oct,
day = "28",
doi = "10.3390/life11111151",
language = "English",
volume = "11",
journal = "LIFE-BASEL",
issn = "2075-1729",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "11",

}

RIS

TY - JOUR

T1 - Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?

AU - Kirsten, Natalia

AU - Rustenbach, Stephan

AU - von Kiedrowski, Ralph

AU - Sorbe, Christina

AU - Reich, Kristian

AU - Augustin, Matthias

PY - 2021/10/28

Y1 - 2021/10/28

N2 - In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters PASI, DLQI, and PBI were intercorrelated and related to two anchoring variables: (1) patient satisfaction with treatment and (2) perceived complete clearance. Baseline data were as follows: PASI 10.5 ± 9.1, DLQI 12.4 ± 3.4, and PBI 2.7 ± 0.3. There was an almost linear relationship between "complete patient satisfaction" and the relative differences in PASI in the range from PASI 25 to PASI 90. However, there was no additional benefit between PASI 90 and PASI 100. The same finding resulted from the anchoring variable "perception of complete healing". When related to DLQI outcomes, relative PASI changes as well as absolute changes and PASI at 3 and 6 months showed relevant differences between the PASI classes 25 to 90 but not between PASI 90 and PASI 100. Under real-world conditions, changes in PASI and DLQI reflect patient-relevant benefits.

AB - In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters PASI, DLQI, and PBI were intercorrelated and related to two anchoring variables: (1) patient satisfaction with treatment and (2) perceived complete clearance. Baseline data were as follows: PASI 10.5 ± 9.1, DLQI 12.4 ± 3.4, and PBI 2.7 ± 0.3. There was an almost linear relationship between "complete patient satisfaction" and the relative differences in PASI in the range from PASI 25 to PASI 90. However, there was no additional benefit between PASI 90 and PASI 100. The same finding resulted from the anchoring variable "perception of complete healing". When related to DLQI outcomes, relative PASI changes as well as absolute changes and PASI at 3 and 6 months showed relevant differences between the PASI classes 25 to 90 but not between PASI 90 and PASI 100. Under real-world conditions, changes in PASI and DLQI reflect patient-relevant benefits.

U2 - 10.3390/life11111151

DO - 10.3390/life11111151

M3 - SCORING: Journal article

C2 - 34833027

VL - 11

JO - LIFE-BASEL

JF - LIFE-BASEL

SN - 2075-1729

IS - 11

M1 - 1151

ER -