Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT'91--implications for investigating childhood medulloblastoma.

  • M A Grotzer
  • K von Hoff
  • André von Bueren
  • T Shalaby
  • W Hartmann
  • M Warmuth-Metz
  • A Emser
  • R D Kortmann
  • J Kuehl
  • T Pietsch
  • S Rutkowski

Abstract

Most recent studies analyzing candidate biological prognostic factors in childhood medulloblastoma (MB) are limited by small patient numbers due to dependence on fresh-frozen tumor material. By contrast, large archives of formalin-fixed, paraffin-embedded MB samples exist from homogeneously treated patients.

Bibliographical data

Original languageGerman
Article number6
ISSN0300-8630
Publication statusPublished - 2007
pubmed 18050040