Vorhofflimmern: Wie wichtig ist der Erhalt des Sinusrhythmus?
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Vorhofflimmern: Wie wichtig ist der Erhalt des Sinusrhythmus? / Meyer, Christian; Metzner, Andreas; Kirchhof, Paulus.
In: DEUT MED WOCHENSCHR, Vol. 145, No. 8, 04.2020, p. 543-549.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Vorhofflimmern: Wie wichtig ist der Erhalt des Sinusrhythmus?
AU - Meyer, Christian
AU - Metzner, Andreas
AU - Kirchhof, Paulus
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2020/4
Y1 - 2020/4
N2 - Rhythm control therapy, comprising antiarrhythmic drugs, cardioversion, and AF ablation, is an important component in the management of patients with atrial fibrillation (AF). Catheter ablation for AF, mainly targeting isolation of the pulmonary veins (AF ablation), has markedly improved the effectiveness of rhythm control therapy. Rhythm control improves symptoms and quality of life in patients with symptomatic AF. AF ablation maintains sinus rhythm more effectively than antiarrhythmic drug therapy. Antiarrhythmic drugs remain effective after AF ablation, underpinning the synergistic mechanisms of action of AF ablation and antiarrhythmic drugs. Different lifestyle interventions might additionally improve symptoms and rhythm stability in patients with AF. AF ablation appears to improve left ventricular function in a subset of patients. Summarized, rhythm control therapy in patients with symptomatic AF is safe and improves quality of life, including elderly patients with stroke risk factors. Further studies are needed to determine whether rhythm control therapy reduces AF-related complications while improving patient outcome with regard to prognosis.
AB - Rhythm control therapy, comprising antiarrhythmic drugs, cardioversion, and AF ablation, is an important component in the management of patients with atrial fibrillation (AF). Catheter ablation for AF, mainly targeting isolation of the pulmonary veins (AF ablation), has markedly improved the effectiveness of rhythm control therapy. Rhythm control improves symptoms and quality of life in patients with symptomatic AF. AF ablation maintains sinus rhythm more effectively than antiarrhythmic drug therapy. Antiarrhythmic drugs remain effective after AF ablation, underpinning the synergistic mechanisms of action of AF ablation and antiarrhythmic drugs. Different lifestyle interventions might additionally improve symptoms and rhythm stability in patients with AF. AF ablation appears to improve left ventricular function in a subset of patients. Summarized, rhythm control therapy in patients with symptomatic AF is safe and improves quality of life, including elderly patients with stroke risk factors. Further studies are needed to determine whether rhythm control therapy reduces AF-related complications while improving patient outcome with regard to prognosis.
KW - Anti-Arrhythmia Agents/therapeutic use
KW - Atrial Fibrillation/complications
KW - Catheter Ablation
KW - Electric Countershock
KW - Humans
KW - Quality of Life
KW - Stroke/etiology
KW - Ventricular Function, Left/physiology
U2 - 10.1055/a-0969-6352
DO - 10.1055/a-0969-6352
M3 - SCORING: Review
C2 - 32294780
VL - 145
SP - 543
EP - 549
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 8
ER -